scholarly journals Clinicopathological Implication of Long Non-Coding RNAs SOX2 Overlapping Transcript and Its Potential Target Gene Network in Various Cancers

2020 ◽  
Vol 10 ◽  
Author(s):  
Yishu Li ◽  
Mengyu Du ◽  
Shengsheng Wang ◽  
Jin Zha ◽  
Peijie Lei ◽  
...  
Keyword(s):  
Gene Network ◽  
Target Gene ◽  
Potential Target Gene ◽  
Potential Target ◽  
Non Coding Rnas

scholarly journals Transcriptome analysis reveals potential function of long non-coding RNAs in 20-hydroxyecdysone regulated autophagy in Bombyx mori

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Huili Qiao ◽  
Jingya Wang ◽  
Yuanzhuo Wang ◽  
Juanjuan Yang ◽  
Bofan Wei ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
Target Gene ◽  
Fat Body ◽  
Expression Profiles ◽  
Functional Characterization ◽  
Differentially Expressed ◽  
Post Injection ◽  
Biological Processes ◽  
Potential Target ◽  
Non Coding Rnas

Abstract Background 20-hydroxyecdysone (20E) plays important roles in insect molting and metamorphosis. 20E-induced autophagy has been detected during the larval–pupal transition in different insects. In Bombyx mori, autophagy is induced by 20E in the larval fat body. Long non-coding RNAs (lncRNAs) function in various biological processes in many organisms, including insects. Many lncRNAs have been reported to be potential for autophagy occurrence in mammals, but it has not been investigated in insects. Results RNA libraries from the fat body of B. mori dissected at 2 and 6 h post-injection with 20E were constructed and sequenced, and comprehensive analysis of lncRNAs and mRNAs was performed. A total of 1035 lncRNAs were identified, including 905 lincRNAs and 130 antisense lncRNAs. Compared with mRNAs, lncRNAs had longer transcript length and fewer exons. 132 lncRNAs were found differentially expressed at 2 h post injection, compared with 64 lncRNAs at 6 h post injection. Thirty differentially expressed lncRNAs were common at 2 and 6 h post-injection, and were hypothesized to be associated with the 20E response. Target gene analysis predicted 6493 lncRNA-mRNA cis pairs and 42,797 lncRNA-mRNA trans pairs. The expression profiles of LNC_000560 were highly consistent with its potential target genes, Atg4B, and RNAi of LNC_000560 significantly decreased the expression of LNC_000560 and Atg4B. These results indicated that LNC_000560 was potentially involved in the 20E-induced autophagy of the fat body by regulating Atg4B. Conclusions This study provides the genome-wide identification and functional characterization of lncRNAs associated with 20E-induced autophagy in the fat body of B. mori. LNC_000560 and its potential target gene were identified to be related to 20-regulated autophagy in B. mori. These results will be helpful for further studying the regulatory mechanisms of lncRNAs in autophagy and other biological processes in this insect model.

scholarly journals miR‑494.3p expression in synovial sarcoma: Role of CXCR4 as a potential target gene

2018 ◽  
Author(s):  
Laura Pazzaglia ◽  
Serena Pollino ◽  
Mattia Vitale ◽  
Elisa Bientinesi ◽  
Stefania Benini ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Target Gene ◽  
Potential Target Gene ◽  
Potential Target

Potential target gene and protein interaction ofPimpinella brachycarpa HD-Zip protein, Phz4 by yeast two-hybrid system

1999 ◽  
Vol 42 (4) ◽  
pp. 302-309
Author(s):  
Sanghyun Lim ◽  
Yong -Hwan Moon ◽  
Jung -Il Cho ◽  
Jong Chan Woo ◽  
Kwang -Woong Lee
Keyword(s):  
Hybrid System ◽  
Protein Interaction ◽  
Target Gene ◽  
Yeast Two Hybrid ◽  
Potential Target Gene ◽  
Potential Target ◽  
Yeast Two Hybrid System ◽  
Two Hybrid

scholarly journals Transcriptome Analysis Reveals Potential Function of Long Non-coding RNAs in 20-hydroxyecdysone Regulated Autophagy in Bombyx Mori

2021 ◽  
Author(s):  
Huili Qiao ◽  
Jingya Wang ◽  
Yuanzhuo Wang ◽  
Juanjuan Yang ◽  
Bofan Wei ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
Target Gene ◽  
Fat Body ◽  
Expression Profiles ◽  
Functional Characterization ◽  
Differentially Expressed ◽  
Post Injection ◽  
Biological Processes ◽  
Potential Target ◽  
Non Coding Rnas

Abstract Background: 20-hydroxyecdysone (20E) plays important roles in insect molting and metamorphosis. 20E-induced autophagy has been detected during the larval–pupal transition in different insects. In Bombyx mori, autophagy is induced by 20E in the larval fat body. Long non-coding RNAs (lncRNAs) function in various biological processes in many organisms, including insects. Many lncRNAs have been reported to be potential for autophagy occurrence in mammals, but it has not been investigated in insects. Results: RNA libraries from the fat body of B. mori dissected at 2 and 6 h post-injection with 20E were sequenced, and comprehensive analysis of lncRNAs and mRNAs was performed. A total of 1035 lncRNAs were identified, including 905 lincRNAs and 130 antisense lncRNAs. Compared with mRNAs, lncRNAs had longer transcript length and fewer exons. 132 lncRNAs were found differentially expressed at 2 h post injection, compared with 64 lncRNAs at 6 h post injection. Thirty differentially expressed lncRNAs were common at 2 and 6 h post-injection, and were hypothesized to be associated with the 20E response. Target gene analysis predicted 6493 lncRNA-mRNA cis pairs and 42797 lncRNA-mRNA trans pairs. The expression profiles of LNC_000560 were highly consistent with its potential target genes, Atg4B, and RNAi of LNC_000560 significantly decreased the expression of Atg4B. These results indicated that LNC_000560 was potentially involved in the 20E-induced autophagy of the fat body by regulating Atg4B. Conclusions: This study provides the genome-wide identification and functional characterization of lncRNAs associated with 20E-induced autophagy in the fat body of B. mori. LNC_000560 and its potential target gene were identified to be related to 20-regulated autophagy in B. mori. These results will be helpful for further studying the regulatory mechanisms of lncRNAs in autophagy and other biological processes in this insect model.

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

2013 ◽  
Vol 48 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Markus Casper ◽  
Susanne N. Weber ◽  
Matthias Kloor ◽  
Roman Müllenbach ◽  
Rainer Grobholz ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lynch Syndrome ◽  
Target Gene ◽  
Potential Target Gene ◽  
Potential Target

scholarly journals AAC as a Potential Target Gene to Control Verticillium dahliae

Genes ◽  
2017 ◽  
Vol 8 (1) ◽  
pp. 25 ◽  
Author(s):  
Xiaofeng Su ◽  
Latifur Rehman ◽  
Huiming Guo ◽  
Xiaokang Li ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Verticillium Dahliae ◽  
Target Gene ◽  
Potential Target Gene ◽  
Potential Target
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