scholarly journals Silencing the Nucleocytoplasmic O-GlcNAc Transferase Reduces Proliferation, Adhesion, and Migration of Cancer and Fetal Human Colon Cell Lines

2016 ◽  
Vol 7 ◽  
Author(s):  
Agata Steenackers ◽  
Stéphanie Olivier-Van Stichelen ◽  
Steffi F. Baldini ◽  
Vanessa Dehennaut ◽  
Robert-Alain Toillon ◽  
...  
2019 ◽  
Author(s):  
C Magoni ◽  
M Forcella ◽  
Giustra CM ◽  
D Panzeri ◽  
F Saliu ◽  
...  

Author(s):  
Douglas Boyd ◽  
Germaine Florent ◽  
Genesio Murano ◽  
Michael Brattain

2006 ◽  
Vol 50 (4-5) ◽  
pp. 413-417 ◽  
Author(s):  
Sandra Schaefer ◽  
Matthias Baum ◽  
Gerhard Eisenbrand ◽  
Christine Janzowski

2010 ◽  
Vol 54 (12) ◽  
pp. 1734-1743 ◽  
Author(s):  
Tamara Bakuradze ◽  
Roman Lang ◽  
Thomas Hofmann ◽  
Herbert Stiebitz ◽  
Gerhard Bytof ◽  
...  

2015 ◽  
Vol 172 ◽  
pp. 183-189 ◽  
Author(s):  
Pu Jing ◽  
Bingjun Qian ◽  
Shujuan Zhao ◽  
Xin Qi ◽  
Ludan Ye ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1060 ◽  
Author(s):  
Fawzia Alblewi ◽  
Rawda Okasha ◽  
Areej Eskandrani ◽  
Tarek Afifi ◽  
Hany Mohamed ◽  
...  

Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon cancer (HCT-116), and liver cancer (HepG-2) activities. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR, and mass spectroscopy. The preliminary results of the bioassay disclosed that some of the target compounds were proven to have a significant antiproliferative effect against the three cell lines, as compared to Doxorubicin, Vinblastine, and Colchicine, used as reference drugs. Particularly, compounds 7 and 14 exerted promising anticancer activity towards all cell lines and were chosen for further studies, such as cell cycle analysis, cell apoptosis, caspase 3/7 activity, DNA fragmentation, cell invasion, and migration. We found that these potent cytotoxic compounds induced cell cycle arrest at the S and G2/M phases, prompting apoptosis. Furthermore, these compounds significantly inhibit the invasion and migration of the different tested cancer cells. The structure-activity relationship (SAR) survey highlights that the antitumor activity of the desired compounds was affected by the hydrophobic or hydrophilic nature of the substituent at different positions.


BioFactors ◽  
2009 ◽  
Vol 35 (5) ◽  
pp. 460-467 ◽  
Author(s):  
Nina Habermann ◽  
Bernd Christian ◽  
Bernd Luckas ◽  
Beatrice L. Pool-Zobel ◽  
Elizabeth K. Lund ◽  
...  

2006 ◽  
Vol 50 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Sandra Schaefer ◽  
Matthias Baum ◽  
Gerhard Eisenbrand ◽  
Helmut Dietrich ◽  
Frank Will ◽  
...  

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