scholarly journals Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

2012 ◽  
Vol 3 ◽  
Author(s):  
Rafael Roesler ◽  
Gilberto Schwartsmann
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Drug Target ◽  
Peptide Receptors ◽  
Gastrin Releasing Peptide ◽  
The Central Nervous System

Gut–brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function

2018 ◽  
Vol 94 (1114) ◽  
pp. 446-452 ◽  
Author(s):  
Borros M Arneth
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Well Being ◽  
Immune System Activation ◽  
Published Evidence ◽  
Bidirectional Communication ◽  
The Central Nervous System ◽  
Intestinal Functions ◽  
The Brain

BackgroundThe gut–brain axis facilitates a critical bidirectional link and communication between the brain and the gut. Recent studies have highlighted the significance of interactions in the gut–brain axis, with a particular focus on intestinal functions, the nervous system and the brain. Furthermore, researchers have examined the effects of the gut microbiome on mental health and psychiatric well-being.The present study reviewed published evidence to explore the concept of the gut–brain axis.AimsThis systematic review investigated the relationship between human brain function and the gut–brain axis.MethodsTo achieve these objectives, peer-reviewed articles on the gut–brain axis were identified in various electronic databases, including PubMed, MEDLINE, CIHAHL, Web of Science and PsycINFO.ResultsData obtained from previous studies showed that the gut–brain axis links various peripheral intestinal functions to brain centres through a broad range of processes and pathways, such as endocrine signalling and immune system activation. Researchers have found that the vagus nerve drives bidirectional communication between the various systems in the gut–brain axis. In humans, the signals are transmitted from the liminal environment to the central nervous system.ConclusionsThe communication that occurs in the gut–brain axis can alter brain function and trigger various psychiatric conditions, such as schizophrenia and depression. Thus, elucidation of the gut–brain axis is critical for the management of certain psychiatric and mental disorders.

scholarly journals Infectious immunity in the central nervous system and brain function

2017 ◽  
Vol 18 (2) ◽  
pp. 132-141 ◽  
Author(s):  
Robyn S Klein ◽  
Charise Garber ◽  
Nicole Howard
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Infectious Immunity ◽  
The Central Nervous System

Effectiveness Of Immunolabeling Gfap For Estimating Astrocytic Shape And Volume

1999 ◽  
Vol 5 (S2) ◽  
pp. 1340-1341
Author(s):  
E. Bushong ◽  
M. E. Martone ◽  
C. Foster ◽  
M. H. Ellisman
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
Brain Function ◽  
Neural Tissue ◽  
Surrounding Tissue ◽  
The Central Nervous System ◽  
Fine Structures ◽  
Transport Of Ions ◽  
Labeling Pattern

Each astrocyte forms an extensive network of fine processes within the surrounding neural tissue, interacting extensively with neighboring neurons and blood vessels. Fine glial processes surround synapses and probably modulate synaptic transmission. Glial endfeet on capillaries are responsible for transport of ions and metabolites and possibly control blood flow. Alterations in these fine structures may be of significance in brain function and disease. Glial fibrillary acidic protein (GFAP) is an intermediate filament found in astrocytes of the central nervous system. GFAP is commonly found in the perikarya and processes of protoplasmic and fibrous type astrocytes. Immunohistochemical labeling of GFAP is extensively used as a means of determining the location and shape of astrocytes. However, its labeling pattern varies with brain region (e.g. cortex vs. hippocampus), with cell state (natural vs. reactive astrocytes), and with the specific α- GFAP antibody used. Furthermore, Golgi-stained or dye-filled astrocytes show numerous small appendages or vellate structures that conform to the surrounding tissue and do not stain for GFAP.

Changes in Porteus Maze Scores of Brain-Operated Schizophrenics After an Eight-Year Interval

1960 ◽  
Vol 106 (444) ◽  
pp. 967-978 ◽  
Author(s):  
Aaron Smith
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Damage ◽  
Brain Function ◽  
Special Importance ◽  
Cortical Lesions ◽  
Additional Source ◽  
Adequate Knowledge ◽  
The Central Nervous System ◽  
Subjective Estimates

The voluminous literature reporting the effects of cortical lesions has shown contradictory and diverse findings from the earliest studies to the present (Franz, 1907; Klebanoff, 1945; Klebanoff, Singer and Wilensky, 1954; Meyer, 1957). Some investigators found no losses in intellectual function regardless of the locus of the lesion; others, a temporary loss followed by recovery of original capacity. Still others have reported significant losses following brain damage in the forebrain or other portions of the central nervous system. But for investigators in all three categories, what did “brain damage” consist of? The neurologists Brain and Strauss have observed “The study of psychological problems without an adequate knowledge of the physiology and pathology of the central nervous system can be likened to the exploration of the uncharted seas without the aid of a compass; and yet there are many psychologists who undertake the rash venture” (1955, p. vi). And what of the criteria on which the conclusions were based? An additional source of ambiguity is indicated by the fact that the overwhelming majority of conclusions on “mental” changes by psychiatrists and neurologists have generally been based on clinical or subjective estimates.Measurement, a crucial factor in any study, is of special importance in studies of brain damage and brain function, although despite a multiplicity of tests, there are few measures designed with attention to their unique problems. Tests employed in many psychological studies of brain damage were originally oriented toward quite different problems and had been carefully developed and standardized on non-brain damaged populations.

Neurocartography: Geometry and Biology of the Central Nervous System

1997 ◽  
Vol 3 (S2) ◽  
pp. 295-296
Author(s):  
O. J. Tretiak ◽  
J. Nissanov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Spatial Organization ◽  
Mrna In Situ Hybridization ◽  
Functional Images ◽  
Recent Developments ◽  
The Central Nervous System ◽  
And Function

The central nervous system of a vertebrate organism exhibits a very complex spatial organization structure and function. These relationships are the subject of intense study for over a century, and recent developments in imaging have attracted ever increasing effort devoted to the understanding of brain function. One can produce any number of quantitative images that provide maps of the anatomy and function of nerve tissues. For example, autoradiography can yield functional images (2-deoxy glucose), maps of neurotransmitters receptors (over 100 know types), and gene expression labeled with complementary mRNA (in-situ hybridization). Immunohistochemistry produces maps of a large variety of neuroactive components, such as transmitters.To illustrate a typical procedure, we describe the mapping of brain function with 2-deoxy glucose (2DG). A rat performing some task is injected with a solution of 2DG radiolabeled with 14C¨ Subsequently, the animal is sacrificed, the brain is cryosectioned (ca. 20 μm), and contact autoradio-grams of these sections are made on X-ray film.

scholarly journals Fetal Brain Function: Lessons Learned and Future Challenges of 4D Sonography

2011 ◽  
Vol 5 (2) ◽  
pp. 85-92
Author(s):  
Aida Salihagic Kadic ◽  
Maja Predojevic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Prenatal Screening ◽  
Fetal Brain ◽  
Modern Technology ◽  
Lessons Learned ◽  
Neonatal Neurology ◽  
Future Challenges ◽  
The Central Nervous System

ABSTRACT Maturation of the central nervous system (CNS) is reflected in fetal behavior. Modern technology, such as four-dimensional (4D) sonography improved assessment of fetal behavior in all three trimesters of pregnancy. After summing our own experiences and experiences of the leading authors in the field of fetal and neonatal neurology, new prenatal screening test for assessment of fetal behavior has been suggested. Test was named Kurjak antenatal neurodevelopmental test (KANET). Up to now results of KANET are encouraging and they have been published in several prominent journals. Nevertheless, potential of KANET in the assessment of integrity of the fetal central nervous system needs to be confirmed by studies that are in progress in several world university centers.

scholarly journals Multiple areas of the cerebral cortex influence the stomach

2020 ◽  
Vol 117 (23) ◽  
pp. 13078-13083 ◽  
Author(s):  
David J. Levinthal ◽  
Peter L. Strick
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Motor Cortex ◽  
Cortical Neurons ◽  
Brain Function ◽  
Primary Motor Cortex ◽  
Gut Function ◽  
Transneuronal Transport ◽  
The Central Nervous System ◽  
Brain Connection

The central nervous system both influences and is influenced by the gastrointestinal system. Most research on this gut–brain connection has focused on how ascending signals from the gut and its microbiome alter brain function. Less attention has focused on how descending signals from the central nervous system alter gut function. Here, we used retrograde transneuronal transport of rabies virus to identify the cortical areas that most directly influence parasympathetic and sympathetic control of the rat stomach. Cortical neurons that influence parasympathetic output to the stomach originated from the rostral insula and portions of medial prefrontal cortex, regions that are associated with interoception and emotional control. In contrast, cortical neurons that influence sympathetic output to the stomach originated overwhelmingly from the primary motor cortex, primary somatosensory cortex, and secondary motor cortex, regions that are linked to skeletomotor control and action. Clearly, the two limbs of autonomic control over the stomach are influenced by distinct cortical networks.

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