scholarly journals Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator

2012 ◽  
Vol 3 ◽  
Author(s):  
Ali Mobasheri
Keyword(s):  
Articular Cartilage ◽  
Signaling Molecule ◽  
Extracellular Signaling

scholarly journals CSF, a Species-Specific Extracellular Signaling Peptide for Communication among Strains of Bacillus subtilis and Bacillus mojavensis

2008 ◽  
Vol 190 (11) ◽  
pp. 4095-4099 ◽  
Author(s):  
Mridula Pottathil ◽  
April Jung ◽  
Beth A. Lazazzera
Keyword(s):  
Bacillus Subtilis ◽  
Mediated Communication ◽  
Signaling Molecule ◽  
Bacillus Mojavensis ◽  
Extracellular Signaling ◽  
Signaling Peptides ◽  
Specific Variation ◽  
Different Strains ◽  
Species Specific

ABSTRACT ComX and CSF are Bacillus subtilis extracellular signaling peptides. Many different strains of B. subtilis do not communicate due to strain-specific variation of ComX. We demonstrate that CSF is a species-specific signaling molecule that partially compensates for the lack of ComX-mediated communication between different strains of B. subtilis.

scholarly journals Purification of an Extracellular Signaling Molecule Involved in Production of Aerial Mycelium by Streptomyces coelicolor

1998 ◽  
Vol 180 (5) ◽  
pp. 1334-1337 ◽  
Author(s):  
Justin R. Nodwell ◽  
Richard Losick
Keyword(s):  
Conditioned Medium ◽  
Streptomyces Coelicolor ◽  
Morphological Differentiation ◽  
Aerial Mycelium ◽  
Signaling Molecule ◽  
Extracellular Signaling ◽  
Import System

ABSTRACT We have extensively purified a factor from conditioned medium that restores aerial mycelium formation to a mutant of Streptomyces coelicolor that is defective in morphological differentiation. Response to this factor is shown to depend on the presence of the BldK oligopeptide import system. We suggest that this substance acts at the first step in a putative cascade of developmental regulatory signals.

Rapid and Specific Imaging of Extracellular Signaling Molecule Adenosine Triphosphate with a Self-Phosphorylating DNAzyme

2021 ◽  
Vol 143 (37) ◽  
pp. 15084-15090
Author(s):  
Dan Zhao ◽  
Dingran Chang ◽  
Qiang Zhang ◽  
Yangyang Chang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Adenosine Triphosphate ◽  
Signaling Molecule ◽  
Extracellular Signaling

Release of Cellular UDP-Glucose as a Potential Extracellular Signaling Molecule

2003 ◽  
Vol 63 (5) ◽  
pp. 1190-1197 ◽  
Author(s):  
Eduardo R. Lazarowski ◽  
Deborah A. Shea ◽  
Richard C. Boucher ◽  
T. Kendall Harden
Keyword(s):  
Signaling Molecule ◽  
Extracellular Signaling

scholarly journals Male-specificIDGF, a Novel Gene Encoding a Membrane-bound Extracellular Signaling Molecule Expressed Exclusively in Testis ofDrosophila melanogaster

2000 ◽  
Vol 275 (47) ◽  
pp. 36934-36941 ◽  
Author(s):  
Takefumi Matsushita ◽  
Ikuko Fujii-Taira ◽  
Yasuhiro Tanaka ◽  
Koichi J. Homma ◽  
Shunji Natori
Keyword(s):  
Gene Encoding ◽  
Signaling Molecule ◽  
Novel Gene ◽  
Extracellular Signaling ◽  
Membrane Bound

scholarly journals Extracellular ATP as an Inter-Kingdom Signaling Molecule: Release Mechanisms by Bacteria and Its Implication on the Host

2020 ◽  
Vol 21 (15) ◽  
pp. 5590
Author(s):  
Daniel Spari ◽  
Guido Beldi
Keyword(s):  
Current Knowledge ◽  
Purinergic Signaling ◽  
Extracellular Atp ◽  
Signaling Molecule ◽  
Host Interactions ◽  
Extracellular Signaling ◽  
Unicellular Organisms ◽  
Intracellular Energy ◽  
Multicellular Organisms ◽  
Intercellular Communications

The purine adenosine 5′-triphosphate (ATP) is not only a universal intracellular energy carrier but plays also an important role as extracellular signaling molecule. Purinergic signaling is involved in many physiological and pathological processes like coagulation, inflammation, or sepsis in mammals. ATP is well-known as a messenger for intercellular communications in multicellular organisms, but phylogenetically much older unicellular organisms like yeast or bacteria use ATP as an extracellular signaling molecule as well. However, the mechanisms of ATP secretion by bacteria and its extracellular implications still have to be elucidated. This review will provide an overview of the current knowledge about bacterial extracellular ATP (eATP) under homeostatic conditions and during growth. Possible secretion mechanisms of ATP by bacteria will be discussed and implications of bacterial ATP are shown, with a focus on bacteria–host interactions.

scholarly journals Intercellular Communication in Helicobacter pylori: luxS Is Essential for the Production of an Extracellular Signaling Molecule

2000 ◽  
Vol 68 (6) ◽  
pp. 3193-3199 ◽  
Author(s):  
Mark H. Forsyth ◽  
Timothy L. Cover
Keyword(s):  
Helicobacter Pylori ◽  
Mutant Strain ◽  
Growth Phase ◽  
Homoserine Lactone ◽  
Conditioned Media ◽  
Signaling Molecule ◽  
Sterile Culture ◽  
Extracellular Signaling ◽  
H Pylori ◽  
Intact Copy

ABSTRACT Individual bacteria of numerous species can communicate and coordinate their actions via the production, release, and detection of extracellular signaling molecules. In this study, we used theVibrio harveyi luminescence bioassay to determine whetherHelicobacter pylori produces such a factor. Cell-free conditioned media from H. pylori strains 60190 and 26695 each induced >100-fold-greater luminescence in V. harveyithan did sterile culture medium. The H. pylori signaling molecule had a molecular mass of <10 kDa, and its activity was unaffected by heating to 80°C for 5 min or protease treatment. The genome sequence of H. pylori 26695 does not contain any gene predicted to encode an acyl homoserine lactone synthase but does contain an orthologue of luxS, which is required for production of autoinducer-2 (AI-2) in V. harveyi. To evaluate the role of luxS in H. pylori, we constructed luxS null mutants derived from H. pylori 60190 and 26695. Conditioned media from the wild-typeH. pylori strains induced >100-fold-greater luminescence in the V. harveyi bioassay than did conditioned medium from either mutant strain. Production of the signaling molecule was restored in an H. pylori luxS null mutant strain by complementation with a single intact copy of luxS placed in a heterologous site on the chromosome. In addition, Escherichia coliDH5α produced autoinducer activity following the introduction of an intact copy of luxS from H. pylori. Production of the signaling molecule by H. pylori was growth phase dependent, with maximal production occurring in the mid-exponential phase of growth. Transcription of H. pylori vacA also was growth phase dependent, but this phenomenon was not dependent onluxS activity. These data indicate that H. pylori produces an extracellular signaling molecule related to AI-2 from V. harveyi. We speculate that this signaling molecule may play a role in regulating H. pylori gene expression.

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