scholarly journals Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19

2020 ◽  
Vol 7 ◽  
Author(s):  
María Galán ◽  
Francesc Jiménez-Altayó
Keyword(s):  
Resistance Artery ◽  
New Paradigm ◽  
Small Resistance ◽  
Artery Disease

Effect of Propofol on Norepinephrine-induced Increases in [Ca2+](i) and Force in Smooth Muscle of the Rabbit Mesenteric Resistance Artery 

1998 ◽  
Vol 88 (6) ◽  
pp. 1566-1578 ◽  
Author(s):  
Nami Imura ◽  
Yoshihisa Shiraishi ◽  
Hirotada Katsuya ◽  
Takeo Itoh
Keyword(s):  
Smooth Muscle ◽  
Isometric Force ◽  
Resistance Artery ◽  
Resistance Arteries ◽  
High K ◽  
Small Resistance ◽  
Vasodilating Activity ◽  
Mesenteric Resistance Artery

Background Propofol (2,6-diisopropylphenol) possesses vasodilating activity in vivo and in vitro. The propofol-induced relaxation of agonist-induced contractions in small resistance arteries has not been clarified. Methods The effect of propofol was examined on the contractions induced by norepinephrine and high K+ in endothelium-denuded rabbit mesenteric resistance artery in vitro. The effects of propofol on the [Ca2+]i mobilization induced by norepinephrine and high K+ were studied by simultaneous measurement of [Ca2+]i using Fura 2 and isometric force in ryanodine-treated strips. Results Propofol attenuated the contractions induced by high K+ and norepinephrine, the effect being greater on the high K+-induced contraction than on the norepinephrine-induced contraction. In Ca2+-free solution, norepinephrine produced a transient contraction resulting from the release of Ca2+ from storage sites that propofol attenuated. In ryanodine-treated strips, propofol increased the resting [Ca2+]i but attenuated the increases in [Ca2+]i and force induced by both high K+ and norepinephrine. In the presence of nicardipine, propofol had no inhibitory action on the residual norepinephrine-induced [Ca2+]i increase, whereas it still modestly increased resting [Ca2+]i, as in the absence of nicardipine. Conclusions In smooth muscle of the rabbit mesenteric resistance artery, propofol attenuates norepinephrine-induced contractions due to an inhibition both of Ca2+ release and of Ca2+ influx through L-type Ca2+ channels. Propofol also increased resting [Ca2+]i, possibly as a result of an inhibition of [Ca2+]i removal mechanisms. These results may explain in part the variety of actions seen with propofol in various types of vascular smooth muscle.

Determinants of Subcutaneous Small Resistance Artery Structure in Hypertensive Patients

2005 ◽  
Vol 12 (3) ◽  
pp. 188
Author(s):  
G. E.M. Boari ◽  
M. L. Muiesan ◽  
E. Porteri ◽  
M. Castellano ◽  
N. Rizzardi ◽  
...  
Keyword(s):  
Resistance Artery ◽  
Hypertensive Patients ◽  
Small Resistance

Risk stratification of individual coronary lesions using local endothelial shear stress: a new paradigm for managing coronary artery disease

2007 ◽  
Vol 22 (6) ◽  
pp. 552-564 ◽  
Author(s):  
Yiannis S Chatzizisis ◽  
Ahmet U Coskun ◽  
Michael Jonas ◽  
Elazer R Edelman ◽  
Peter H Stone ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Shear Stress ◽  
Coronary Artery ◽  
Risk Stratification ◽  
New Paradigm ◽  
Endothelial Shear Stress ◽  
Coronary Lesions ◽  
Artery Disease
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