scholarly journals qSOFA Score Is Useful to Assess Disease Severity in Patients With Heart Failure in the Setting of a Heart Failure Unit (HFU)

2020 ◽  
Vol 7 ◽  
Author(s):  
Tobias Wagner ◽  
Christoph Sinning ◽  
Jonas Haumann ◽  
Christina Magnussen ◽  
Stefan Blankenberg ◽  
...  
Keyword(s):  
Heart Failure ◽  
Disease Severity ◽  
Heart Failure Unit ◽  
Patients With Heart Failure ◽  
Qsofa Score

Mortality and Cause of Death in Patients With Heart Failure: Findings at a Specialist Multidisciplinary Heart Failure Unit

2010 ◽  
Vol 63 (3) ◽  
pp. 303-314 ◽  
Author(s):  
Ferran Pons ◽  
Josep Lupón ◽  
Agustín Urrutia ◽  
Beatriz González ◽  
Eva Crespo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cause Of Death ◽  
Heart Failure Unit ◽  
Patients With Heart Failure

Low voltage on the electrocardiogram is a marker of disease severity and a risk factor for adverse outcomes in patients with heart failure due to systolic dysfunction

2006 ◽  
Vol 152 (2) ◽  
pp. 355-361 ◽  
Author(s):  
Sandeep A. Kamath ◽  
Januario de P. Meo Neto ◽  
Russell M. Canham ◽  
Fatema Uddin ◽  
Kathleen H. Toto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Risk Factor ◽  
Disease Severity ◽  
Low Voltage ◽  
Systolic Dysfunction ◽  
Adverse Outcomes ◽  
Patients With Heart Failure

scholarly journals Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

2019 ◽  
Vol 8 (12) ◽  
pp. 2230
Author(s):  
Lukas Lanser ◽  
Gerhard Pölzl ◽  
Dietmar Fuchs ◽  
Günter Weiss ◽  
Katharina Kurz
Keyword(s):  
Heart Failure ◽  
Disease Severity ◽  
Immune Activation ◽  
Nyha Class ◽  
Heart Association ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Increased Risk ◽  
Patients With Heart Failure

Inflammation and immune activation play an important role in the pathogenesis of cardiac remodelling in patients with heart failure. The aim of this study was to assess whether biomarkers of inflammation and immune activation are linked to disease severity and the prognosis of heart failure patients. In 149 patients (65.8% men, median age 49.7 years) with heart failure from nonischaemic cardiomyopathy, the biomarkers neopterin and C-reactive protein were tested at the time of diagnosis. Patients were followed-up for a median of 58 months. During follow-up, nineteen patients died, five had a heart transplantation, two needed a ventricular assistance device, and twenty-one patients had to be hospitalised because of heart failure decompensation. Neopterin concentrations correlated with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations (rs = 0.399, p < 0.001) and rose with higher New York Heart Association (NYHA) class (I: 5.60 nmol/L, II: 6.90 nmol/L, III/IV: 7.80 nmol/L, p = 0.033). Higher neopterin levels were predictive for an adverse outcome (death or hospitalisation due to HF decompensation), independently of age and sex and of established predictors in heart failure such as NYHA class, NT-proBNP, estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LV-EF) (HR 2.770; 95% CI 1.419–5.407; p = 0.003). Patients with a neopterin/eGFR ratio ≥ 0.133 (as a combined marker for immune activation and kidney function) had a more than eightfold increased risk of reaching an endpoint compared to patients with a neopterin/eGFR ratio ≤0.065 (HR 8.380; 95% CI 2.889–24.308; p < 0.001). Neopterin is associated with disease severity and is an independent predictor of prognosis in patients with heart failure.

Direct measurements of lipid peroxidation are present in patients with heart failure: Do they correlate with disease severity?

1999 ◽  
Vol 5 (3) ◽  
pp. 72
Author(s):  
Lawrence Baruch ◽  
Tariq Jamil ◽  
Proserfino Patacsil ◽  
Sujjud Ahmed ◽  
Jill Kalman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Lipid Peroxidation ◽  
Disease Severity ◽  
Direct Measurements ◽  
Patients With Heart Failure

scholarly journals Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy

2021 ◽  
Author(s):  
Karina Oliveira Garcia ◽  
Thiago Cerqueira Silva ◽  
Maria do Carmo Pereira Nunes ◽  
Iuri Ferreira Felix ◽  
Murilo Araujo Oliveira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Disease Severity ◽  
Chagas Disease ◽  
Cardiac Disease ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Significant Difference ◽  
Patients With Heart Failure ◽  
Chagasic Cardiomyopathy ◽  
And Gender

Chagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and dementia. In the present study, we selected five candidate biomarkers for Chagas disease: interleukin-6, membrane metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP1), orosomucoid, and neprilysin. We sought to determine if mean levels of proinflammatory biomarkers are higher in patients with heart failure (HF) associated with Chagas disease when compared with other etiologies of HF. Patients were consecutively enrolled from subspecialty HF outpatient clinics at two university-based hospitals. Serum biomarker levels from blood samples were analyzed by ELISA. Severity of HF on echocardiography was worse in non-CD when compared with CD patients. No significant difference was observed in the levels of candidate biomarkers between the CD and non-CD groups. We found a significantly 2.2 ng/mL higher level of TIMP1 in CD when compared with non-CD patients with HF after adjustment for age and gender (95% confidence interval = 0.1 to 4.5, P = 0.037). In patients with heart failure, serum TIMP1 is increased in Chagas patients despite a lower myocardial disease severity on echocardiography when compared with non-Chagas patients. TIMP1 is probably one of multiple mediators of inflammatory injury.

scholarly journals Anaemia and coronary artery disease severity in patients with heart failure

2005 ◽  
Vol 8 (1) ◽  
pp. 54-57 ◽  
Author(s):  
G. Michael Felker ◽  
Wendy Gattis Stough ◽  
Linda K. Shaw ◽  
Christopher M. O'Connor
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Coronary Artery Disease Severity ◽  
Patients With Heart Failure ◽  
Artery Disease
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