scholarly journals Analysis of the Zonula occludens Toxin Found in the Genome of the Chilean Non-toxigenic Vibrio parahaemolyticus Strain PMC53.7

2020 ◽  
Vol 10 ◽  
Author(s):  
Diliana Pérez-Reytor ◽  
Alequis Pavón ◽  
Carmen Lopez-Joven ◽  
Sebastián Ramírez-Araya ◽  
Carlos Peña-Varas ◽  
...  
Keyword(s):  
Vibrio Parahaemolyticus ◽  
Parahaemolyticus Strain ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

Human zonulin, a potential modulator of intestinal tight junctions

2000 ◽  
Vol 113 (24) ◽  
pp. 4435-4440 ◽  
Author(s):  
W. Wang ◽  
S. Uzzau ◽  
S.E. Goldblum ◽  
A. Fasano
Keyword(s):  
Tight Junction ◽  
Tight Junctions ◽  
Ussing Chamber ◽  
Intestinal Lumen ◽  
Epithelial Surface ◽  
Ussing Chambers ◽  
Zonula Occludens ◽  
Surface Receptor ◽  
Dynamic Structures ◽  
Zonula Occludens Toxin

Intercellular tight junctions are dynamic structures involved in vectorial transport of water and electrolytes across the intestinal epithelium. Zonula occludens toxin derived from Vibrio cholerae interacts with a specific intestinal epithelial surface receptor, with subsequent activation of a complex intracellular cascade of events that regulate tight junction permeability. We postulated that this toxin may mimic the effect of a functionally and immunologically related endogenous modulator of intestinal tight junctions. Affinity-purified anti-zonula occludens toxin antibodies and the Ussing chamber assay were used to screen for one or more mammalian zonula occludens toxin analogues in both fetal and adult human intestine. A novel protein, zonulin, was identified that induces tight junction disassembly in non-human primate intestinal epithelia mounted in Ussing chambers. Comparison of amino acids in the active zonula occludens toxin fragment and zonulin permitted the identification of the putative receptor binding domain within the N-terminal region of the two proteins. Zonulin likely plays a pivotal role in tight junction regulation during developmental, physiological, and pathological processes, including tissue morphogenesis, movement of fluid, macromolecules and leukocytes between the intestinal lumen and the interstitium, and inflammatory/autoimmune disorders.

scholarly journals Genomic basis of antibiotic resistance in Vibrio parahaemolyticus strain JPA1

2019 ◽  
Vol 114 ◽  
Author(s):  
Felipe Hernandes Coutinho ◽  
Diogo Antonio Tschoeke ◽  
Maysa Mandetta Clementino ◽  
Cristiane Carneiro Thompson ◽  
Fabiano Lopes Thompson
Keyword(s):  
Antibiotic Resistance ◽  
Vibrio Parahaemolyticus ◽  
Parahaemolyticus Strain ◽  
Genomic Basis

Dissociation of ZO1-occludin complex is involved in zonula occludens toxin (Zot)-mediated disassembly of intestinal tight junctions

2001 ◽  
Vol 120 (5) ◽  
pp. A699
Author(s):  
Tammara L. Watts ◽  
Timothy D. Kiser ◽  
Regina A. Macatangay ◽  
Simeon E. Goldblum ◽  
Alessio Fasano
Keyword(s):  
Tight Junctions ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

scholarly journals Distribution of thezot(zonula occludens toxin) gene among strains ofVibrio cholerae01 and non-01

1993 ◽  
Vol 106 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Tadahiro Karasawa ◽  
Tatsuya Mihara ◽  
Hisao Kurazono ◽  
G. Balakrish Nair ◽  
Surabhi Garg ◽  
...  
Keyword(s):  
Toxin Gene ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

FURTHER INSIGHT INTO PRODUCTION AND DIARRHEAGENICITY OF ZONULA OCCLUDENS TOXIN (ZOT) BY VIBRIO CHOLERAE

1991 ◽  
Vol 13 (3) ◽  
pp. 327
Author(s):  
A. Fasano ◽  
B. Baudry ◽  
J. B. Kaper ◽  
C. Ciarla ◽  
L. Ferraro ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin ◽  
Insight Into

scholarly journals Isolation of a Pandemic O3:K6 Clone of a Vibrio parahaemolyticus Strain from Environmental and Clinical Sources in Thailand

2000 ◽  
Vol 66 (6) ◽  
pp. 2685-2689 ◽  
Author(s):  
Varaporn Vuddhakul ◽  
Ashrafazzuman Chowdhury ◽  
Varaporn Laohaprertthisan ◽  
Punnee Pungrasamee ◽  
Nuanjira Patararungrong ◽  
...  
Keyword(s):  
Vibrio Parahaemolyticus ◽  
Clinical Case ◽  
Parahaemolyticus Strain ◽  
Enrichment Method ◽  
Southern Thailand ◽  
Immunomagnetic Enrichment ◽  
Arbitrarily Primed Pcr

ABSTRACT Application of an immunomagnetic enrichment method selective forVibrio parahaemolyticus serovar K6 allowed isolation of a strain belonging to the pandemic O3:K6 clone of V. parahaemolyticus from fresh shellfish not implicated in a clinical case in southern Thailand. Arbitrarily primed PCR profiles of this strain, clinical O3:K6 strains isolated from sporadic diarrhea cases in the same area, and a standard pandemic O3:K6 strain were indistinguishable.

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