scholarly journals Long-Term Protection Elicited by a DNA Vaccine Candidate Expressing the prM-E Antigen of Dengue Virus Serotype 3 in Mice

2020 ◽  
Vol 10 ◽  
Author(s):  
Kaihao Feng ◽  
Xiaoyan Zheng ◽  
Ran Wang ◽  
Na Gao ◽  
Dongying Fan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Vaccine Candidate ◽  
Virus Serotype

scholarly journals Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing Dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice

2019 ◽  
Vol 34 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Ziyang Sheng ◽  
Hui Chen ◽  
Kaihao Feng ◽  
Na Gao ◽  
Ran Wang ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Virus Serotype

scholarly journals Virus-Like Particle Secretion and Genotype-Dependent Immunogenicity of Dengue Virus Serotype 2 DNA Vaccine

2014 ◽  
Vol 88 (18) ◽  
pp. 10813-10830 ◽  
Author(s):  
J. U. Galula ◽  
W.-F. Shen ◽  
S.-T. Chuang ◽  
G.-J. J. Chang ◽  
D.-Y. Chao
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Virus Like Particle ◽  
Virus Serotype ◽  
Dengue Virus Serotype 2

Induction of multiple cytotoxic T lymphocyte responses in mice by a multiepitope DNA vaccine against dengue virus serotype 1

2016 ◽  
Vol 60 (12) ◽  
pp. 835-845 ◽  
Author(s):  
Xin Yu Chen ◽  
De Zhou Li ◽  
Xiao Zhi Zhong ◽  
Bokun Chen ◽  
Zhi Liang Duan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Lymphocyte Responses ◽  
Dengue Virus Serotype 1

Absolute quantification of dengue virus serotype 4 chimera vaccine candidate in Vero cell culture by targeted mass spectrometry

PROTEOMICS ◽  
2015 ◽  
Vol 15 (19) ◽  
pp. 3320-3330 ◽  
Author(s):  
Blandine Rougemont ◽  
Romain Simon ◽  
Romain Carrière ◽  
Jordane Biarc ◽  
Catherine Fonbonne ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cell Culture ◽  
Dengue Virus ◽  
Vero Cell ◽  
Vaccine Candidate ◽  
Absolute Quantification ◽  
Vero Cell Culture ◽  
Virus Serotype

scholarly journals Immunogenicity of Recombinant DNA Vaccine Encoding Non-Structural Protein-1 Dengue Virus Serotype-2 in Balb/c Mice

2021 ◽  
Vol 15 (2) ◽  
pp. 69-75
Author(s):  
FITHRIYAH SJATHA ◽  
◽  
ELITHA SUNDARI PULUNGAN ◽  
TJAHJANI MIRAWATI SUDIRO ◽  
◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Recombinant Dna ◽  
Structural Protein ◽  
Virus Serotype ◽  
Dengue Virus Serotype 2

A dengue virus serotype-1 DNA vaccine induces virus neutralizing antibodies and provides protection from viral challenge in Aotus monkeys

Vaccine ◽  
2000 ◽  
Vol 18 (27) ◽  
pp. 3166-3173 ◽  
Author(s):  
T.J Kochel ◽  
K Raviprakash ◽  
C.G Hayes ◽  
D.M Watts ◽  
K.L Russell ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Neutralizing Antibodies ◽  
Viral Challenge ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotype 1

scholarly journals Immunogenicity of Recombinant DNA Vaccine Encoding Non-Structural Protein-1 Dengue Virus Serotype-2 in Balb/c Mice

2021 ◽  
Vol 15 (2) ◽  
pp. 4
Author(s):  
Elitha Pulungan
Keyword(s):  
Immune Response ◽  
Dengue Virus ◽  
Dna Vaccine ◽  
Humoral Immune Response ◽  
Structural Proteins ◽  
Ns1 Protein ◽  
Structural Protein ◽  
Humoral Immune ◽  
Virus Serotype ◽  
Positive Strand Rna

Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus (DENV) which spread widely in tropical and subtropical regions of the world. DENV is a single-positive strand RNA virus with a genome size of ± 11kb which encodes three structural proteins, seven non-structural proteins, and two untranslated regions (UTR). The non-structural protein-1 (NS1) of DENV is known to have important role in dengue pathogenesis also promising to be developed as dengue vaccine. Lately, novel vaccine approach by DNA immunization have given new perspective for a safe, stable, and immunogenic vaccine platform. Previously, we have successfully construct DNA vaccine encoding NS1 protein of DENV2 (pUNS1) which express recombinant NS1 protein in-vitro. Thus, in this current study the ability of pUNS1 to induce humoral immune response will be further analyzed by in mice immunization. Methods: Sixteen BALB/c mice aged of 4 weeks were immunized 3 times with 100 µg of pUNS1 or pUMVC4a on 2 week time interval. Blood sampling was carried out just before immunization and termination was done 2 week after last immunization. Titer from individual mice sera against DENV-2 were measure with in-house ELISA. Results: IgG against NS1 protein of DENV2 titer from mice group immunized with recombinant pUNS1 shown high ELISA absorbancies, 5 times higher than pUMVC4a group. This result suggest the ability of pUNS1 to induce humoral immune response against NS1 DENV-2 in-vivo. Conclusion: Recombinant pUNS1 can induce humoral immune response in mice.

scholarly journals Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate

2020 ◽  
Vol 41 (1) ◽  
pp. 90-93 ◽  
Author(s):  
Wang Ran ◽  
Yang Fu-Jia ◽  
Zheng Xiao-Yan ◽  
Liao Xian-Zheng ◽  
Fan Dong-Ying ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Vaccine Candidate ◽  
Dengue Viruses
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