scholarly journals Marked Changes in Gut Microbiota in Cardio-Surgical Intensive Care Patients: A Longitudinal Cohort Study

2020 ◽  
Vol 9 ◽  
Author(s):  
Heleen Aardema ◽  
Paola Lisotto ◽  
Alexander Kurilshikov ◽  
Janneke R. J. Diepeveen ◽  
Alex W. Friedrich ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Gut Microbiota ◽  
Longitudinal Cohort Study ◽  
Surgical Intensive Care ◽  
Longitudinal Cohort ◽  
Intensive Care Patients

Lactate dehydrogenase as an indicator of severe illness in neonatal intensive care patients: a longitudinal cohort study

2012 ◽  
Vol 101 (12) ◽  
pp. 1225-1231 ◽  
Author(s):  
Mathias Karlsson ◽  
Khu T K Dung ◽  
Truong L Thi ◽  
Erik Borgström ◽  
Karin Jonstam ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Lactate Dehydrogenase ◽  
Neonatal Intensive Care ◽  
Longitudinal Cohort Study ◽  
Severe Illness ◽  
Longitudinal Cohort ◽  
Intensive Care Patients

scholarly journals Outcomes When Using Adjunct Dexmedetomidine with Propofol Sedation in Mechanically Ventilated Surgical Intensive Care Patients

Pharmacy ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 93
Author(s):  
Jessica Louie ◽  
Nick Lonardo ◽  
Mary Mone ◽  
Vanessa Stevens ◽  
Rishi Deka ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Intensive Care ◽  
A Priori ◽  
Absolute Difference ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Mechanically Ventilated ◽  
Intensive Care Patients ◽  
Continuous Sedation

Objective: Compare the duration of mechanical ventilation between patients receiving sedation with continuous infusions of propofol alone or combination with the use of dexmedetomidine and propofol. Design: Retrospective, propensity matched (1:1) cohort study, employing eight variables chosen a priori for matching. Timing of exposure to dexmedetomidine initiation was incorporated into a matching algorithm. Setting: Level 1, university-based, 32-bed, adult, mixed trauma and surgical intensive care unit (SICU). Continuous sedation was delivered according to a protocol methodology with daily sedation vacation and spontaneous breathing trials. Choice of sedation agent was physician directed. Patients: Between 2010 and 2014, 149 SICU patients receiving mechanical ventilation for >24 h received dexmedetomidine with propofol. Propensity matching resulted in 143 pair cohorts. Interventions: Dexmedetomidine with propofol or propofol alone. Measurements and Main Results: There was no statistical difference in SICU length of stay (LOS), with a median absolute difference of 5.3 h for propofol alone group (p = 0.43). The SICU mortality was not statistically different (RR = 1.002, p = 0.88). Examining a 14-day period post-treatment with dexmedetomidine, on any given day (excluding days 1 and 14), dexmedetomidine with propofol-treated patients had a 0.5% to 22.5% greater likelihood of being delirious (CAM-ICU positive). In addition, dexmedetomidine with propofol-treated patients had a 4.5% to 18.8% higher likelihood of being above the target sedation score (more agitated) compared to propofol-alone patients. Conclusions: In this propensity matched cohort study, adjunct use of dexmedetomidine to propofol did not show a statistically significant reduction with respect to mechanical ventilation (MV) duration, SICU LOS, or SICU mortality, despite a trend toward receiving fewer hours of propofol. There was no evidence that dexmedetomidine with propofol improved sedation scores or reduced delirium.

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