scholarly journals Innate Immune Response of Primary Human Keratinocytes to West Nile Virus Infection and Its Modulation by Mosquito Saliva

2018 ◽  
Vol 8 ◽  
Author(s):  
Magali Garcia ◽  
Haoues Alout ◽  
Fodé Diop ◽  
Alexia Damour ◽  
Michèle Bengue ◽  
...  
Keyword(s):  
Immune Response ◽  
West Nile Virus ◽  
Virus Infection ◽  
Innate Immune Response ◽  
West Nile Virus Infection ◽  
Human Keratinocytes ◽  
Innate Immune ◽  
Primary Human Keratinocytes ◽  
West Nile ◽  
Mosquito Saliva

scholarly journals Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0232585 ◽  
Author(s):  
Benoit Besson ◽  
Justine Basset ◽  
Sandrine Gatellier ◽  
Hélène Chabrolles ◽  
Thibault Chaze ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Japanese Encephalitis ◽  
Potential Role ◽  
West Nile Virus Infection ◽  
Neuronal Model ◽  
West Nile ◽  
Mosquito Saliva

scholarly journals Innate immune control of West Nile virus infection

2011 ◽  
Vol 13 (11) ◽  
pp. 1648-1658 ◽  
Author(s):  
Alvaro Arjona ◽  
Penghua Wang ◽  
Ruth R. Montgomery ◽  
Erol Fikrig
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
West Nile Virus Infection ◽  
Innate Immune ◽  
Immune Control ◽  
West Nile

scholarly journals Vγ4+T cells regulate host immune response to West Nile virus infection

2011 ◽  
Vol 63 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Thomas Welte ◽  
Judith Aronson ◽  
Bin Gong ◽  
Aparna Rachamallu ◽  
Nicole Mendell ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
West Nile Virus ◽  
Virus Infection ◽  
West Nile Virus Infection ◽  
Host Immune Response ◽  
West Nile

scholarly journals Mosquito Saliva Causes Enhancement of West Nile Virus Infection in Mice

2010 ◽  
Vol 85 (4) ◽  
pp. 1517-1527 ◽  
Author(s):  
L. M. Styer ◽  
P.-Y. Lim ◽  
K. L. Louie ◽  
R. G. Albright ◽  
L. D. Kramer ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
West Nile Virus Infection ◽  
West Nile ◽  
Mosquito Saliva

scholarly journals West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction

2008 ◽  
Vol 82 (17) ◽  
pp. 8262-8271 ◽  
Author(s):  
Jason R. Wilson ◽  
Paola Florez de Sessions ◽  
Megan A. Leon ◽  
Frank Scholle
Keyword(s):  
Signal Transduction ◽  
Immune Response ◽  
West Nile Virus ◽  
Innate Immune Response ◽  
Mammalian Cells ◽  
Innate Immune ◽  
Productive Infection ◽  
West Nile ◽  
Antiviral State ◽  
Nonstructural Protein 1

ABSTRACT The innate immune response is the first line of defense against foreign pathogens. The recognition of virus-associated molecular patterns, including double- and single-stranded RNA, by pattern recognition receptors initiates a cascade of signaling reactions. These result in the transcriptional upregulation and secretion of proinflammatory cytokines that induce an antiviral state. Many viruses have evolved mechanisms to antagonize these responses in order to help them establish a productive infection. We have previously shown that West Nile virus (WNV) is able to inhibit Toll-like receptor 3 (TLR3)-mediated activation of interferon (IFN) regulatory factor 3 (IRF3) (F. Scholle and P. W. Mason, Virology 342:77-87, 2005). In the present study, the WNV nonstructural (NS) proteins were analyzed individually for their ability to antagonize signal transduction mediated by TLR3. We report that expression of WNV NS1 inhibits TLR3-induced transcriptional activation of the IFN-β promoter and of an NF-κB-responsive promoter. This inhibition was due to a failure of the TLR3 ligand poly(I:C) to induce nuclear translocation of IRF3 and NF-κB. Furthermore, NS1 expression also inhibited TLR3-dependent production of interleukin-6 and the establishment of an antiviral state. The function of NS1 in flavivirus infection is not well understood. NS1 is required for viral RNA replication and is also secreted from mammalian cells but not from insect cells. Here, we identify a previously unrecognized role for NS1 in the modulation of signaling pathways of the innate immune response to WNV infection.

scholarly journals The early protective innate immune response against West Nile virus

2008 ◽  
Vol 2 (S1) ◽  
Author(s):  
Stephane Daffis ◽  
Melanie A Samuel ◽  
Mehul S Suthar ◽  
Brian K Keller ◽  
Michael Gale ◽  
...  
Keyword(s):  
Immune Response ◽  
West Nile Virus ◽  
Innate Immune Response ◽  
Innate Immune ◽  
West Nile
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