scholarly journals The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule

2018 ◽  
Vol 8 ◽  
Author(s):  
Tina Guina ◽  
Lynda L. Lanning ◽  
Kristian S. Omland ◽  
Mark S. Williams ◽  
Larry A. Wolfraim ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Efficacy ◽  
Cynomolgus Macaque ◽  
Natural History Model ◽  
Animal Rule

scholarly journals PSY21 PROJECTING THE ECONOMIC OUTCOMES OF OBESITY USING A NATURAL HISTORY MODEL

2010 ◽  
Vol 13 (3) ◽  
pp. A209
Author(s):  
B Wang ◽  
L Garrison ◽  
R Alfonso ◽  
D Flum ◽  
D Arteburn ◽  
...  
Keyword(s):  
Natural History ◽  
Economic Outcomes ◽  
Natural History Model

A Revised Natural History Model for Primary Sclerosing Cholangitis

2000 ◽  
Vol 75 (7) ◽  
pp. 688-694 ◽  
Author(s):  
W. RAY KIM ◽  
TERRY M. THERNEAU ◽  
RUSSELL H. WIESNER ◽  
JOHN J. POTERUCHA ◽  
JOANNE T. BENSON ◽  
...  
Keyword(s):  
Natural History ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Natural History Model

Drifting, Controlling and Overcoming: Opiate Users Who Avoid Becoming Chronically Dependent

1983 ◽  
Vol 13 (2) ◽  
pp. 219-235 ◽  
Author(s):  
Judith Stephenson Blackwell
Keyword(s):  
Natural History ◽  
Loss Of Control ◽  
Extensive Experience ◽  
Use Patterns ◽  
Opiate Use ◽  
Natural History Model ◽  
And Control

Despite extensive experience with opiates, not all users become dependent. This study of 51 users (12 females, 39 males) attempts to identify the kinds of controls they employed over their consumption. One third of the sample had been in a state of “drift” and had not found regulation to be necessary. A second group had developed rules to govern their consumption and to prevent loss of control. Just over one-quarter of the sample (14 respondents) had experienced episodes of dependence; the ways by which these episodes were overcome are described. A natural history model of opiate use has been developed from the use patterns and control styles found in the sample. By accident, I met a college acquaintance, who recommended opium. Opium! dread agent of unimaginable pleasure and pain! I had heard of it as I heard of manna or of ambrosia, but no further. How unmeaning a sound was opium at that time! What solemn chords does it now strike upon my heart! what heart-quaking vibrations of sad and happy remembrances! Reverting for a moment to these, I feel a mystic importance attached to minutest circumstances connected with the place, and the time, and the man (if man it was), that first laid open to me the paradise of opium-eaters. (De Quincey, 1822; 1966:197–198)

The Natural History of Bone Bruises

1998 ◽  
Vol 26 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Mark D. Miller ◽  
John R. Osborne ◽  
Wade T. Gordon ◽  
Daniel T. Hinkin ◽  
Mark R. Brinker
Keyword(s):  
Natural History ◽  
Medial Collateral Ligament ◽  
Cruciate Ligament ◽  
Ligament Injuries ◽  
Collateral Ligament ◽  
Anterior Cruciate Ligament Injuries ◽  
Natural History Model ◽  
Bone Bruises ◽  
Anterior Cruciate ◽  
A Prospective Study

We conducted a prospective study to evaluate bone bruises, or trabecular microfractures, associated with isolated medial collateral ligament injuries. Magnetic resonance imaging was performed on 65 patients with isolated medial collateral ligament injuries determined by physical examination and imaging studies. Of these 65 patients, 29 (45%) had associated trabecular microfractures. Follow-up images were completed at various intervals on 24 of these 29 patients (83%). Complete resolution of these lesions was observed in all cases. This process appears to occur as a result of gradual diffusion over a period of 2 to 4 months. Bone bruises associated with medial collateral ligament injuries are approximately one-half as common as bone bruises associated with anterior cruciate ligament injuries. However, medial collateral ligament-associated trabecular microfractures may be a better natural history model because these injuries are treated nonoperatively.

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