scholarly journals Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

2017 ◽  
Vol 7 ◽  
Author(s):  
Yuhai Zhao ◽  
Vivian Jaber ◽  
Walter J. Lukiw
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gi Tract ◽  
Potential Impact ◽  
Secretory Products

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

2016 ◽  
Vol 146 ◽  
pp. 404-417 ◽  
Author(s):  
Lilian Calderón-Garcidueñas ◽  
Rafael Reynoso-Robles ◽  
Javier Vargas- Martínez ◽  
Aline Gómez-Maqueo-Chew ◽  
Beatriz Pérez-Guillé ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
White Matter ◽  
Mexico City ◽  
Neurovascular Unit ◽  
Potential Impact ◽  
White Matter Pathology

scholarly journals Are signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiforme?

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
William G. O'Neal ◽  
Debomoy K. Lahiri, Ph.D ◽  
Mahua Dey, M.D ◽  
Ruizhi Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glioblastoma Multiforme ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Synaptic Proteins ◽  
Low Grade ◽  
Inverse Association ◽  
Potential Impact ◽  
Cell Signaling Pathways

Background: Epidemiological studies suggest an inverse association between cancer and neurodegenerative disorders, including Alzheimer’s disease (AD). AD and cancers, such as glioblastoma multiforme (GBM), are characterized by abnormal but opposing cellular behavior. AD is characterized by accumulation of the processing products of amyloid β (Aβ) and its metabolizing enzymes amyloid precursor protein (APP), β-secretase (or BACE1), and γ-secretase. Our rationale is unraveling cell signaling pathways linking AD and GBM. We hypothesized low-grade gliomas (LGG) and high-grade gliomas (HGG) would have differential expression of neuronal and synaptic markers. Furthermore, protein expression profiles of these markers, APP metabolites, and BACE1 would be different among LGG, HGG, and AD cases.  Experimental Design or project methods: Specific neuronal protein markers (e.g., NSE), presynaptic proteins (e.g., synaptophysin and SNAP25), and post-synaptic proteins (e.g., PSD-95) have been measured in glioma samples. Characterization are done by Western immunoblotting and ELISA. Protein biomarkers will be analyzed in LGG and HGG of biopsy samples, and the results will be compared with brain samples from AD cases.  Results: Using specific primary and secondary antibodies and optimal protein range, we have standardized an immunoblotting procedure to detect our desired proteins in blinded LGG and HGG samples. After unblinding and analyzing results, expression signals will be compared between GBM and AD brain samples.  Conclusion and potential impact: Our results would shed light on diverging and/or shared cell signaling pathways between AD and GBM. In addition, potential impact would be utilizing GBM-derived cultures to test and develop therapeutics for both AD and GBM.

scholarly journals P4-099: GASTROINTESTINAL (GI) TRACT MICROBIOME-MEDIATED UP-REGULATION OF MICRORNA-146A IN SPORADIC ALZHEIMER'S DISEASE BRAIN

2019 ◽  
Vol 15 ◽  
pp. P1313-P1313
Author(s):  
Yuhai Zhao ◽  
Nathan M. Sharfman ◽  
Vivian Jaber ◽  
Wenhong LI ◽  
Walter J. Lukiw
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gi Tract ◽  
Sporadic Alzheimer’S Disease

scholarly journals Outcome of Alzheimer's Disease: Potential Impact of Cholinesterase Inhibitors

2006 ◽  
Vol 61 (5) ◽  
pp. 516-520 ◽  
Author(s):  
S. Gillette-Guyonnet ◽  
S. Andrieu ◽  
F. Cortes ◽  
F. Nourhashemi ◽  
C. Cantet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibitors ◽  
Potential Impact

scholarly journals Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maurizio Bergamino ◽  
Ryan R. Walsh ◽  
Ashley M. Stokes
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Free Water ◽  
Potential Impact ◽  
Magnetic Resonance Imaging Mri ◽  
Underlying Pathology ◽  
Diffusion Tensor Imaging Dti

AbstractMagnetic resonance imaging (MRI) based diffusion tensor imaging (DTI) can assess white matter (WM) integrity through several metrics, such as fractional anisotropy (FA), axial/radial diffusivities (AxD/RD), and mode of anisotropy (MA). Standard DTI is susceptible to the effects of extracellular free water (FW), which can be removed using an advanced free-water DTI (FW-DTI) model. The purpose of this study was to compare standard and FW-DTI metrics in the context of Alzheimer’s disease (AD). Data were obtained from the Open Access Series of Imaging Studies (OASIS-3) database and included both healthy controls (HC) and mild-to-moderate AD. With both standard and FW-DTI, decreased FA was found in AD, mainly in the corpus callosum and fornix, consistent with neurodegenerative mechanisms. Widespread higher AxD and RD were observed with standard DTI; however, the FW index, indicative of AD-associated neurodegeneration, was significantly elevated in these regions in AD, highlighting the potential impact of free water contributions on standard DTI in neurodegenerative pathologies. Using FW-DTI, improved consistency was observed in FA, AxD, and RD, and the complementary FW index was higher in the AD group as expected. With both standard and FW-DTI, higher values of MA coupled with higher values of FA in AD were found in the anterior thalamic radiation and cortico-spinal tract, most likely arising from a loss of crossing fibers. In conclusion, FW-DTI better reflects the underlying pathology of AD and improves the accuracy of DTI metrics related to WM integrity in Alzheimer’s disease.

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