scholarly journals Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System

2017 ◽  
Vol 7 ◽  
Author(s):  
Aindrila Biswas ◽  
Timothy French ◽  
Henning P. Düsedau ◽  
Nancy Mueller ◽  
Monika Riek-Burchardt ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
Neutrophil Granulocytes ◽  
The Central Nervous System ◽  
Toxoplasma Gondii Infection

scholarly journals CCR2 Receptor Is Essential to Activate Microbicidal Mechanisms to Control Toxoplasma gondii Infection in the Central Nervous System

2008 ◽  
Vol 173 (3) ◽  
pp. 741-751 ◽  
Author(s):  
Luciana Benevides ◽  
Cristiane Maria Milanezi ◽  
Lucy Megumi Yamauchi ◽  
Cláudia Farias Benjamim ◽  
João Santana Silva ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
The Central Nervous System ◽  
Toxoplasma Gondii Infection

Toxoplasma gondii infection of the central nervous system

1981 ◽  
Vol 12 (8) ◽  
pp. 690-698 ◽  
Author(s):  
Frances K. Conley ◽  
Kay Ann Jenkins ◽  
Jack S. Remington
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
The Central Nervous System ◽  
Toxoplasma Gondii Infection

scholarly journals Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Christoph Konradt ◽  
Norikiyo Ueno ◽  
David A. Christian ◽  
Jonathan H. Delong ◽  
Gretchen Harms Pritchard ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Endothelial Cells ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
The Central Nervous System

scholarly journals Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Gabriela C Olivera ◽  
Emily C Ross ◽  
Christiane Peuckert ◽  
Antonio Barragan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Toxoplasma Gondii ◽  
Blood Brain Barrier ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Cortical Capillaries ◽  
The Brain

The cellular barriers of the central nervous system proficiently protect the brain parenchyma from infectious insults. Yet, the single-celled parasite Toxoplasma gondii commonly causes latent cerebral infection in humans and other vertebrates. Here, we addressed the role of the cerebral vasculature in the passage of T. gondii to the brain parenchyma. Shortly after inoculation in mice, parasites mainly localized to cortical capillaries, in preference over post-capillary venules, cortical arterioles or meningeal and choroidal vessels. Early invasion to the parenchyma (days 1-5) occurred in absence of a measurable increase in blood-brain barrier (BBB) permeability, perivascular leukocyte cuffs or hemorrhage. However, sparse focalized permeability elevations were detected adjacently to replicative parasite foci. Further, T. gondii triggered inflammatory responses in cortical microvessels and endothelium. Pro- and anti-inflammatory treatments of mice with LPS and hydrocortisone, respectively, impacted BBB permeability and parasite loads in the brain parenchyma. Finally, pharmacological inhibition or Cre/loxP conditional knockout of endothelial focal adhesion kinase (FAK), a BBB intercellular junction regulator, facilitated parasite translocation to the brain parenchyma. The data reveal that the initial passage of T. gondii to the central nervous system occurs principally across cortical capillaries. The integrity of the microvascular BBB restricts parasite transit, which conversely is exacerbated by the inflammatory response.

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