scholarly journals Host interferon-γ inducible protein contributes to Brucella survival

2012 ◽  
Vol 2 ◽  
Author(s):  
Jennifer A. Ritchie ◽  
Adam Rupper ◽  
James A. Cardelli ◽  
Bryan H. Bellaire
Keyword(s):  
Interferon Γ ◽  
Inducible Protein

scholarly journals Endogenous CXCL10/Interferon‐γ‐Inducible Protein (IP)‐10 orchestrates myocardial infarct healing

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Marcin J. Bujak ◽  
Thorsten Leucker ◽  
Pawel Zymek ◽  
Vikas Veeranna ◽  
Peter Huebener ◽  
...  
Keyword(s):  
Myocardial Infarct ◽  
Interferon Γ ◽  
Infarct Healing ◽  
Inducible Protein

scholarly journals cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

2015 ◽  
Vol 112 (14) ◽  
pp. E1773-E1781 ◽  
Author(s):  
Megan H. Orzalli ◽  
Nicole M. Broekema ◽  
Benjamin A. Diner ◽  
Dustin C. Hancks ◽  
Nels C. Elde ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Fibroblasts ◽  
Interferon Γ ◽  
Viral Dna ◽  
Human Foreskin Fibroblasts ◽  
Infected Cells ◽  
Inducible Protein ◽  
The Stability ◽  
Simplex Virus

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two DNA sensors could both be required for this response. We therefore investigated their relative roles in human foreskin fibroblasts (HFFs) infected with HSV or transfected with plasmid DNA. siRNA depletion studies showed that both are required for the production of IFN in infected HFFs. We found that cGAS shows low production of cGMP-AMP in infected cells, but instead cGAS is partially nuclear in normal human fibroblasts and keratinocytes, interacts with IFI16 in fibroblasts, and promotes the stability of IFI16. IFI16 is associated with viral DNA and targets to viral genome complexes, consistent with it interacting directly with viral DNA. Our results demonstrate that IFI16 and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling.

scholarly journals Inflammatory cytokines in major depressive disorder: A case–control study

2016 ◽  
Vol 51 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Paolo Cassano ◽  
Eric Bui ◽  
Andrew H Rogers ◽  
Zandra E Walton ◽  
Rachel Ross ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sampling Bias ◽  
Interferon Γ ◽  
Small Sample ◽  
Major Depressive ◽  
Course Of Illness ◽  
Luminex Technology ◽  
Cytokine Levels ◽  
Inducible Protein

Introduction: There is mixed evidence in the literature on the role of inflammation in major depressive disorder. Contradictory findings are attributed to lack of rigorous characterization of study subjects, to the presence of concomitant medical illnesses, to the small sample sizes, and to the limited number of cytokines tested. Methods: Subjects aged 18–70 years, diagnosed with major depressive disorder and presenting with chronic course of illness, as well as matched controls ( n = 236), were evaluated by trained raters and provided blood for cytokine measurements. Cytokine levels in EDTA plasma were measured with the MILLIPLEX Multi-Analyte Profiling Human Cytokine/Chemokine Assay employing Luminex technology. The Wilcoxon rank-sum test was used to compare cytokine levels between major depressive disorder subjects and healthy volunteers, before (interleukin [IL]-1β, IL-6, and tumor necrosis factor-α) and after Bonferroni correction for multiple comparisons (IL-1α, IL-2, IL-3, IL-4, IL-5, IL-7, IL-8, IL-10, IL-12(p40), IL-12(p70), IL-13, IL-15, IFN-γ-inducible protein 10, Eotaxin, interferon-γ, monotype chemoattractant protein-1, macrophage inflammatory protein-1α, granulocyte-macrophage colony-stimulating factor and vascular endothelial growth factor). Results: There were no significant differences in cytokine levels between major depressive disorder subjects and controls, both prior to and after correction for multiple analyses (significance set at p ⩽ 0.05 and p ⩽ 0.002, respectively). Conclusion: Our well-characterized examination of cytokine plasma levels did not support the association of major depressive disorder with systemic inflammation. The heterogeneity of major depressive disorder, as well as a potential sampling bias selecting for non-inflammatory depression, might have determined our findings discordant with the literature.

Interferon γ–Inducible Protein 10 Selectively Inhibits Proliferation and Induces Apoptosis in Endothelial Cells

2006 ◽  
Vol 13 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Elizabeth D. Feldman ◽  
David M. Weinreich ◽  
Nancy M. Carroll ◽  
Monika L. Burness ◽  
Andrew L. Feldman ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Interferon Γ ◽  
Inducible Protein

Modification of dendritic cells with interferon-γ-inducible protein-10 gene to enhance vaccine potency

2009 ◽  
Vol 11 (10) ◽  
pp. 889-898 ◽  
Author(s):  
Tae Heung Kang ◽  
Hyun Cheol Bae ◽  
Seok-Ho Kim ◽  
Su Hong Seo ◽  
Sang Wook Son ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Interferon Γ ◽  
Vaccine Potency ◽  
Inducible Protein

scholarly journals Induction of Interferon-γ-Inducible Protein 10 by SARS-CoV Infection, Interferon Alfacon 1 and Interferon Inducer in Human Bronchial Epithelial Calu-3 Cells and BALB/c Mice

2010 ◽  
Vol 20 (4) ◽  
pp. 169-177 ◽  
Author(s):  
Yohichi Kumaki ◽  
Craig W Day ◽  
Kevin W Bailey ◽  
Miles K Wandersee ◽  
Min-Hui Wong ◽  
...  
Keyword(s):  
Interferon Γ ◽  
Interferon Inducer ◽  
Bronchial Epithelial ◽  
Inducible Protein
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