scholarly journals A Mild, Fast, and Scalable Synthesis of Substituted α-Acyloxy Ketones via Multicomponent Reaction Using a Continuous Flow Approach

2019 ◽  
Vol 7 ◽  
Author(s):  
Carlos Eduardo M. Salvador ◽  
Carlos Kleber Z. Andrade
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Scalable Synthesis

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

scholarly journals Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry

2021 ◽  
Author(s):  
Jessica Orrego‐Hernández ◽  
Helen Hölzel ◽  
Maria Quant ◽  
Zhihang Wang ◽  
Kasper Moth‐Poulsen
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry ◽  
Scalable Synthesis

scholarly journals Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene using Continuous Flow Chemistry

2021 ◽  
Author(s):  
Jessica Orrego-Hernández ◽  
Helen Hölzel ◽  
Maria Quant ◽  
Zhihang Wang ◽  
Kasper Moth-Poulsen
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry ◽  
Scalable Synthesis

Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine

Synthesis ◽  
2012 ◽  
Vol 44 (15) ◽  
pp. 2469-2473 ◽  
Author(s):  
Jing Liu ◽  
Anne Fitzgerald ◽  
Neelakandha Mani
Keyword(s):  
Continuous Flow ◽  
Reductive Amination ◽  
Scalable Synthesis

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

2017 ◽  
Vol 19 (6) ◽  
pp. 1454-1461 ◽  
Author(s):  
Maurice A. Marsini ◽  
Frederic G. Buono ◽  
Jon C. Lorenz ◽  
Bing-Shiou Yang ◽  
Jonathan T. Reeves ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Curtius Rearrangement ◽  
Ccr1 Antagonist ◽  
Scalable Synthesis ◽  
Robust Synthesis

A convergent and robust synthesis of a developmental CCR1 antagonist is described using continuous flow technology.

A scalable synthesis of ternary nanocatalysts for a high-efficiency electrooxidation catalysis by microfluidics

Nanoscale ◽  
2020 ◽  
Vol 12 (23) ◽  
pp. 12647-12654
Author(s):  
Yingyan Zhou ◽  
Dumei Wang ◽  
Xueming Kang ◽  
Dongtang Zhang ◽  
Xiangnan Dou ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Efficiency ◽  
Scale Up ◽  
High Dispersion ◽  
Nanomaterials Synthesis ◽  
Scalable Synthesis

An array-channel continuous flow scale-up strategy based on a microchip for high dispersion of loaded PtFeCu/C nanocatalysts for nanomaterials’ synthesis is reported.

Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions

2019 ◽  
Vol 9 (24) ◽  
pp. 6841-6851 ◽  
Author(s):  
Romaric Gérardy ◽  
Julien Estager ◽  
Patricia Luis ◽  
Damien P. Debecker ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Flow Process ◽  
Organic Carbonates ◽  
Scalable Synthesis

A scalable intensified flow process for the preparation of cyclic organic carbonates relying on a cheap ammonium organocatalyst.

scholarly journals Implementation of Biocatalysis in Continuous Flow for the Synthesis of Small Cyclic Amines

2020 ◽  
Vol 74 (11) ◽  
pp. 890-894
Author(s):  
Eimear Hegarty ◽  
Francesca Paradisi
Keyword(s):  
Continuous Flow ◽  
Catalytic Mechanism ◽  
Cyclic Ketones ◽  
Diverse Range ◽  
Cyclic Amines ◽  
Halomonas Elongata ◽  
Prochiral Ketones ◽  
Scalable Synthesis ◽  
Large Substituent ◽  
Made In

Significant progress has been made in establishing transaminases as robust biocatalysts for the green and scalable synthesis of a diverse range of chiral amines. However, very few examples on the amination of small cyclic ketones have been reported. Cyclic ketones are particularly challenging for transaminase enzymes because they do not display the well-defined small and large substituent areas that are characteristic for the bio- catalytic mechanism. In this work, we exploited the broad substrate scope of the (S)-selective transaminase from Halomonas elongata (HeWT) to develop an efficient biocatalytic system in continuous flow to generate a range of small cyclic amines which feature very often in pharmaceuticals and agrochemicals. [3] Tetrahydrofuran-3-one and other challenging prochiral ketones were rapidly (5–45 min) transformed to their corresponding amines with excellent molar conversion (94–99%) and moderate to excellent ee.

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