scholarly journals Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol

2021 ◽  
Vol 8 ◽  
Author(s):  
Salma Pathan-Chhatbar ◽  
Carina Drechsler ◽  
Kirsten Richter ◽  
Anna Morath ◽  
Wei Wu ◽  
...  
Keyword(s):  
T Cell ◽  
Cholesterol Concentration ◽  
Cell Antigen ◽  
Tm Domain ◽  
The One ◽  
Tcr Activation ◽  
The Impact ◽  
Plasma Membrane Cholesterol ◽  
Cholesterol Binding

Biological membranes consist of hundreds of different lipids that together with the embedded transmembrane (TM) proteins organize themselves into small nanodomains. In addition to this function of lipids, TM regions of proteins bind to lipids in a very specific manner, but the function of these TM region-lipid interactions is mostly unknown. In this review, we focus on the role of plasma membrane cholesterol, which directly binds to the αβ T cell antigen receptor (TCR), and has at least two opposing functions in αβ TCR activation. On the one hand, cholesterol binding to the TM domain of the TCRβ subunit keeps the TCR in an inactive, non-signaling conformation by stabilizing this conformation. This assures that the αβ T cell remains quiescent in the absence of antigenic peptide-MHC (the TCR's ligand) and decreases the sensitivity of the T cell toward stimulation. On the other hand, cholesterol binding to TCRβ leads to an increased formation of TCR nanoclusters, increasing the avidity of the TCRs toward the antigen, thus increasing the sensitivity of the αβ T cell. In mouse models, pharmacological increase of the cholesterol concentration in T cells caused an increase in TCR clustering, and thereby enhanced anti-tumor responses. In contrast, the γδ TCR does not bind to cholesterol and might be regulated in a different manner. The goal of this review is to put these seemingly controversial findings on the impact of cholesterol on the αβ TCR into perspective.

scholarly journals How Will the Use of Technology in Translation and Testing Affect Language Learning?

2014 ◽  
Vol 8 (1) ◽  
pp. 22 ◽  
Author(s):  
David Michael Bourne
Keyword(s):  
Language Learning ◽  
Language Proficiency ◽  
Educational Institutions ◽  
Human Element ◽  
Use Of Technology ◽  
The One ◽  
Impact Of Technology ◽  
Age Range ◽  
The Impact

Technology has an ever increasing impact on how we work and live. Article adressed the issue of the impact of technology in two key areas of language learning. On the one side learners increasingly used technology to translate. Given this trend, was there any real need to learn a language. On the other side, educational institutions increasingly used technology to rate language proficiency. Given this trend, would the work of the teacher become less and less important. The survey was conducted by using quantitative method. The respondents’ age range was 18-25. There were 53 respondents, 35% were male and 65% were female. The instrument was a questionaire having 9 questions describing the students’ reliance on computer in translation. It can be concluded that learners of English indicate that they accept and welcome the role of technology in language learning, but there is a doubt that the role and participation of humans in the learning process will be completely replaced. The human element remains an important ingredient. (EE)

scholarly journals Inferring recent evolutionary changes in speech sounds

2021 ◽  
Vol 376 (1824) ◽  
Author(s):  
Steven Moran ◽  
Nicholas A. Lester ◽  
Eitan Grossman
Keyword(s):  
Language Contact ◽  
Language Evolution ◽  
Speech Sounds ◽  
Theme Issue ◽  
Short Term ◽  
The Past ◽  
Evolutionary Changes ◽  
The One ◽  
The Impact

In this paper, we investigate evolutionarily recent changes in the distributions of speech sounds in the world's languages. In particular, we explore the impact of language contact in the past two millennia on today's distributions. Based on three extensive databases of phonological inventories, we analyse the discrepancies between the distribution of speech sounds of ancient and reconstructed languages, on the one hand, and those in present-day languages, on the other. Furthermore, we analyse the degree to which the diffusion of speech sounds via language contact played a role in these discrepancies. We find evidence for substantive differences between ancient and present-day distributions, as well as for the important role of language contact in shaping these distributions over time. Moreover, our findings suggest that the distributions of speech sounds across geographic macro-areas were homogenized to an observable extent in recent millennia. Our findings suggest that what we call the Implicit Uniformitarian Hypothesis, at least with respect to the composition of phonological inventories, cannot be held uncritically. Linguists who would like to draw inferences about human language based on present-day cross-linguistic distributions must consider their theories in light of even short-term language evolution. This article is part of the theme issue ‘Reconstructing prehistoric languages’.

scholarly journals Energy Saving as an Important Factor in Ensuring Product Competitiveness

2021 ◽  
Vol 2 (48) ◽  
pp. 120-125
Author(s):  
O. P. Vashkiv ◽  
◽  
S. B. Smereka ◽  
Keyword(s):  
Energy Saving ◽  
Specific Energy Consumption ◽  
Environmental Standards ◽  
Manufacturing Enterprise ◽  
Research Results ◽  
Industrial Enterprises ◽  
The Face ◽  
The One ◽  
The Impact

The article is aimed at studying the features of energy saving at a manufacturing enterprise and establishing a cause-and-effect relationship between energy saving and product competitiveness. Due to analyzing and generalizing the research results of domestic and foreign scientists the views of researchers on the process of energy saving at a manufacturing enterprise are systematized; the growing role of energy saving in ensuring energy efficiency and, consequently, product competitiveness is established. The research results show that energy saving at an enterprise is one of its most important assets, the impact of which on the level of product competitiveness is becoming increasingly important in the face of the exacerbating energy and environmental crises. Energy saving, basically focusing on the intensification of production processes and use of energy and energy resources, on the one hand, reduces the level of specific energy consumption and, consequently, the price of the released product while maintaining or increasing its quality; on the other hand, it reduces the carbon loading on the environment, thus contributes to the growth of the company's image among its consumers and partners. Both components are the most important factors in ensuring product competitiveness. The development and implementation of energy saving measures at industrial enterprises, with regard to the industry-specific character of economic entities, market conditions, and the requirements of environmental standards can serve as prospects for further research

University Social Responsibility

2021 ◽  
pp. 230-241
Author(s):  
Doina Stratu-Strelet ◽  
Anna Karina López-Hernández ◽  
Vicente Guerola-Navarro ◽  
Hermenegildo Gil-Gómez ◽  
Raul Oltra-Badenes
Keyword(s):  
Knowledge Management ◽  
Private Sector ◽  
The Other ◽  
Public Private Partnerships ◽  
Market Strategy ◽  
Private Partnership ◽  
The One ◽  
Dissemination Of Results ◽  
The Impact

This chapter highlights the role of technology-based universities in public-private partnerships (PPP) to strengthen and deploy the digital single market strategy. Moreover, it analyzes how these collaboration channels have link knowledge management as a tool for sustainable collaboration. Given the need to establish collaboration channels with the private sector, according to Lee, it is critical to establish the impact of sharing sophisticated knowledge and partnering at the same time. This chapter wants to highlights two relevant aspects of PPP: on the one hand, the importance of integrating the participation of a technology-based university with three objectives: (1) the coordination, (2) the funding management, and (3) the dissemination of results; and the other hand, the participation private sector that is represented by agile agents capable to execute high-value actions for society. With the recognition of these values, the investment and interest of the projects under way are justified by public-private partnership.

scholarly journals The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor.

1994 ◽  
Vol 180 (1) ◽  
pp. 401-406 ◽  
Author(s):  
M Izquierdo ◽  
S Bowden ◽  
D Cantrell
Keyword(s):  
T Cells ◽  
T Cell ◽  
Map Kinases ◽  
Interleukin 2 ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Constitutively Active

Triggering of the T cell antigen receptor (TCR) complex activates the serine/threonine kinase Raf-1 whose function is necessary for TCR induction of the interleukin 2 gene. Raf-1 has been identified as a candidate mitogen-activated protein (MAP) kinase kinase kinase (MKKK) and thus has the potential to couple the TCR to the activation of the MAP kinases such as ERK2. In the present study, the role of Raf-1 in ERK2 regulation of ERK2 in T cells has been explored. A constitutively active Raf-1 kinase, v-raf, or a dominant inhibitory Raf-1 mutant were expressed transiently from the pEF BOS vector in Jurkat cells and the effects of these Raf-1 mutants on a coexpressed ERK2 reporter was assessed. The action of the constitutively active Raf-1 was to stimulate the ERK2 kinase, whereas the dominant negative version of Raf-1 inhibited the ERK2 activation induced by triggering of the TCR. These data indicate a role for Raf-1 in the regulation of ERK2 in T cells.

Representations of the (woman) judge: Hercules, the little mermaid, and the vain and naked Emperor

Legal Studies ◽  
2002 ◽  
Vol 22 (4) ◽  
pp. 602-624 ◽  
Author(s):  
Erika Rackley
Keyword(s):  
Fairy Tale ◽  
The Other ◽  
Women Judges ◽  
Other Hand ◽  
The One ◽  
The Impact ◽  
Alternative Understanding ◽  
Woman Judge

This paper reconsiders images of the judge and, in particular, the position of the woman judge using fairy tale and myth. It begins by exploring the actuality of women's exclusion within the judiciary, traditional explanations for this and the impact of recent changes. It goes on to consider the image of the Herculean judge, arguing that whilst we may view him as an ideological construct, or even as a fairy tale, we routinely deny this to ourselves and to others. This both ensures the normative survival of Hercules and simultaneously constrains counter-images of judges, including that of the woman judge, who becomes almost a contradiction in terms, faced with the need to shed her difference and fit the fairy tale. Like the little mermaid, the woman judge must trade her voice for partial acceptance in the prince's world.This image of silencing which Andersen's tale so vividly captures highlights a paradox in current discourses of adjudication. On the one hand, women judges are viewed as desirable in order to broaden the range of perspectives on the bench, thus making the judiciary more representative; on the other hand, judges are supposed to be without perspective, thus suggesting there is little need for a representative judiciary. Feminists and other commentators negotiate their way uncomfortably through this territory, acknowledging a gender dimension to adjudication, but failing fully to confront its implications. This paper seeks to ‘undress’ the judge, to flush out images of adjudication which deter or prevent women from joining the judiciary and constrain their potential within it. It highlights both the role of the imagination in existing conceptions of adjudication and the increasing necessity for a re-imagined Hercules – an alternative understanding of the judge which women and other groups currently underrepresented on the bench can comfortably and constructively occupy.

scholarly journals Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

1989 ◽  
Vol 8 (12) ◽  
pp. 3651-3656 ◽  
Author(s):  
A.M. Weissman ◽  
S.J. Frank ◽  
D.G. Orloff ◽  
M. Merćep ◽  
J.D. Ashwell ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Zeta Chain

scholarly journals The impact of belatacept on the phenotypic heterogeneity of renal T cell–mediated alloimmune response: The critical role of maintenance treatment and inflammatory load

2020 ◽  
Vol 34 (11) ◽  
Author(s):  
Dejan Dobi ◽  
Flavio Vincenti ◽  
Sindhu Chandran ◽  
John R. Greenland ◽  
Christopher Bowman ◽  
...  
Keyword(s):  
T Cell ◽  
Maintenance Treatment ◽  
Critical Role ◽  
Phenotypic Heterogeneity ◽  
The Impact
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