scholarly journals Mitochondrial Ca2 + Is Related to Mitochondrial Activity and Dynamic Events in Mouse Oocytes

2020 ◽  
Vol 8 ◽  
Author(s):  
Feng Wang ◽  
Tie-Gang Meng ◽  
Jian Li ◽  
Yi Hou ◽  
Shi-Ming Luo ◽  
...  
Keyword(s):  
Mitochondrial Activity ◽  
Mouse Oocytes ◽  
Dynamic Events

scholarly journals Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Feng Wang ◽  
Ang Li ◽  
Tie-Gang Meng ◽  
Le-Yun Wang ◽  
Li-Juan Wang ◽  
...  
Keyword(s):  
Mitochondrial Activity ◽  
Mouse Oocytes

scholarly journals Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10074 ◽  
Author(s):  
Natalia Igosheva ◽  
Andrey Y. Abramov ◽  
Lucilla Poston ◽  
Judith J. Eckert ◽  
Tom P. Fleming ◽  
...  
Keyword(s):  
Maternal Diet ◽  
Redox Status ◽  
Mitochondrial Activity ◽  
Mouse Oocytes ◽  
Diet Induced Obesity

scholarly journals Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity

Aging ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 4093-4106 ◽  
Author(s):  
Wendan Xu ◽  
Lingjun Li ◽  
Jingwen Sun ◽  
Songyue Zhu ◽  
Zhengjie Yan ◽  
...  
Keyword(s):  
Mitochondrial Activity ◽  
Mouse Oocytes ◽  
Postovulatory Aging

Cytoprotective Effect of Tocotrienol-Rich Fraction and α-Tocopherol Vitamin E Isoforms Against Glutamate-Induced Cell Death in Neuronal Cells

2014 ◽  
Vol 84 (3-4) ◽  
pp. 0140-0151 ◽  
Author(s):  
Thilaga Rati Selvaraju ◽  
Huzwah Khaza’ai ◽  
Sharmili Vidyadaran ◽  
Mohd Sokhini Abd Mutalib ◽  
Vasudevan Ramachandran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cell Viability ◽  
Neuronal Cells ◽  
Positive Control ◽  
Post Treatment ◽  
Mitochondrial Activity ◽  
Before And After ◽  
Pre Treatment ◽  
Tocotrienol Rich Fraction ◽  
Major Mediator

Glutamate is the major mediator of excitatory signals in the mammalian central nervous system. Extreme amounts of glutamate in the extracellular spaces can lead to numerous neurodegenerative diseases. We aimed to clarify the potential of the following vitamin E isomers, tocotrienol-rich fraction (TRF) and α-tocopherol (α-TCP), as potent neuroprotective agents against glutamate-induced injury in neuronal SK-N-SH cells. Cells were treated before and after glutamate injury (pre- and post-treatment, respectively) with 100 - 300 ng/ml TRF/α-TCP. Exposure to 120 mM glutamate significantly reduced cell viability to 76 % and 79 % in the pre- and post-treatment studies, respectively; however, pre- and post-treatment with TRF/α-TCP attenuated the cytotoxic effect of glutamate. Compared to the positive control (glutamate-injured cells not treated with TRF/α-TCP), pre-treatment with 100, 200, and 300 ng/ml TRF significantly improved cell viability following glutamate injury to 95.2 %, 95.0 %, and 95.6 %, respectively (p < 0.05).The isomers not only conferred neuroprotection by enhancing mitochondrial activity and depleting free radical production, but also increased cell viability and recovery upon glutamate insult. Our results suggest that vitamin E has potent antioxidant potential for protecting against glutamate injury and recovering glutamate-injured neuronal cells. Our findings also indicate that both TRF and α-TCP could play key roles as anti-apoptotic agents with neuroprotective properties.

GH is related to hepatic mitochondrial activity in humans

2017 ◽  
Author(s):  
Peter Wolf ◽  
Sabina Smajis ◽  
Martin Gajdosiik ◽  
Lorenz Pfleger ◽  
Yvonne Winhofer ◽  
...  
Keyword(s):  
Mitochondrial Activity

Regulation of spontaneous and induced resumption of meiosis in mouse oocytes by different intracellular pathways

Reproduction ◽  
2000 ◽  
pp. 377-383 ◽  
Author(s):  
L Leonardsen ◽  
A Wiersma ◽  
M Baltsen ◽  
AG Byskov ◽  
CY Andersen
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Mitogen Activated Protein Kinase ◽  
Meiotic Maturation ◽  
Mouse Oocytes ◽  
Mitogen Activated Protein ◽  
Dependent Signal ◽  
Kinase Pathway ◽  
Kinase A

The mitogen-activated protein kinase-dependent and the cAMP-protein kinase A-dependent signal transduction pathways were studied in cultured mouse oocytes during induced and spontaneous meiotic maturation. The role of the mitogen-activated protein kinase pathway was assessed using PD98059, which specifically inhibits mitogen-activated protein kinase 1 and 2 (that is, MEK1 and MEK2), which activates mitogen-activated protein kinase. The cAMP-dependent protein kinase was studied by treating oocytes with the protein kinase A inhibitor rp-cAMP. Inhibition of the mitogen-activated protein kinase pathway by PD98059 (25 micromol l(-1)) selectively inhibited the stimulatory effect on meiotic maturation by FSH and meiosis-activating sterol (that is, 4,4-dimethyl-5alpha-cholest-8,14, 24-triene-3beta-ol) in the presence of 4 mmol hypoxanthine l(-1), whereas spontaneous maturation in the absence of hypoxanthine was unaffected. This finding indicates that different signal transduction mechanisms are involved in induced and spontaneous maturation. The protein kinase A inhibitor rp-cAMP induced meiotic maturation in the presence of 4 mmol hypoxanthine l(-1), an effect that was additive to the maturation-promoting effect of FSH and meiosis-activating sterol, indicating that induced maturation also uses the cAMP-protein kinase A-dependent signal transduction pathway. In conclusion, induced and spontaneous maturation of mouse oocytes appear to use different signal transduction pathways.

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