scholarly journals Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells

2020 ◽  
Vol 8 ◽  
Author(s):  
Lin Ren ◽  
Xiaodan Chen ◽  
Xiaobing Chen ◽  
Jiayan Li ◽  
Bin Cheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mitochondrial Dynamics ◽  
Fate Determination

scholarly journals Autophagy in fate determination of mesenchymal stem cells and bone remodeling

2020 ◽  
Vol 12 (8) ◽  
pp. 776-786
Author(s):  
Xiao-Dan Chen ◽  
Jia-Li Tan ◽  
Yi Feng ◽  
Li-Jia Huang ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Remodeling ◽  
Fate Determination

scholarly journals Retraction Note: The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yonghui Li ◽  
Melissa Ramcharan ◽  
Zuping Zhou ◽  
Daniel J. Leong ◽  
Takintope Akinbiyi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fate Determination

scholarly journals MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells

RSC Advances ◽  
2019 ◽  
Vol 9 (64) ◽  
pp. 37300-37311 ◽  
Author(s):  
Zixiang Wu ◽  
Shujing Liang ◽  
Wenyu Kuai ◽  
Lifang Hu ◽  
Airong Qian
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Fate ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Recent Advances

The recent advances of miRNAs and lncRNAs in determining the cell fate of MSCs.

scholarly journals The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yonghui Li ◽  
Melissa Ramcharan ◽  
Zuping Zhou ◽  
Daniel J. Leong ◽  
Takintope Akinbiyi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Maximal Response ◽  
Multipotent Stem Cells ◽  
Fate Determination ◽  
Tenogenic Differentiation ◽  
Morphogenetic Protein ◽  
Embryonic Tendon

Abstract Mesenchymal stem cells (MSCs) are pluripotent cells that primarily differentiate into osteocytes, chondrocytes and adipocytes. Recent studies indicate that MSCs can also be induced to generate tenocyte-like cells; moreover, MSCs have been suggested to have great therapeutic potential for tendon pathologies. Yet the precise molecular cascades governing tenogenic differentiation of MSCs remain unclear. We demonstrate scleraxis, a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of MSC towards tenocyte differentiation. Using murine C3H10T1/2 pluripotent stem cells as a model system, we show scleraxis is extensively expressed in the early phase of bone morphogenetic protein (BMP)-12-triggered tenocytic differentiation. Once induced, scleraxis directly transactivates tendon lineage-related genes such as tenomodulin and suppresses osteogenic, chondrogenic and adipogenic capabilities, thus committing C3H10T1/2 cells to differentiate into the specific tenocyte-like lineage, while eliminating plasticity for other lineages. We also reveal that mechanical loading-mediated tenocytic differentiation follows a similar pathway and that BMP-12 and cyclic uniaxial strain act in an additive fashion to augment the maximal response by activating signal transducer Smad8. These results provide critical insights into the determination of multipotent stem cells to the tenocyte lineage induced by both chemical and physical signals.

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