scholarly journals Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway

2020 ◽  
Vol 8 ◽  
Author(s):  
Weiyu Ni ◽  
Feizhou Zhang ◽  
Lin Zheng ◽  
Lili Wang ◽  
Yi Liang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Intervertebral Disk ◽  
Cyclin Dependent Kinase ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Cdk9 Inhibitor

Ultrashort Time-to-Echo MRI of the Cartilaginous Endplate: Technique and Association with Intervertebral Disk Degeneration

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1319972-s-0032-1319972
Author(s):  
T. Law ◽  
M. P. Anthony ◽  
D. Samartzis ◽  
Q. Chan ◽  
M. Kim ◽  
...  
Keyword(s):  
Intervertebral Disk ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Cartilaginous Endplate

Combination of MRI and 99mTc-NTP 15-5 Scintigraphy for the Assessment of Intervertebral Disk Degeneration and Tissue Engineering

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1319873-s-0032-1319873
Author(s):  
P. Colombier ◽  
J. Clouet ◽  
E. Miot-Noirault ◽  
A. Vidal ◽  
F. Cachin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Intervertebral Disk ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration

scholarly journals Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Qi Sun ◽  
Xin-Yu Nan ◽  
Fa-Ming Tian ◽  
Fang Liu ◽  
Shao-Hua Ping ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Lumbar Fusion ◽  
B Cell Lymphoma ◽  
Intervertebral Disk ◽  
Ovariectomized Rats ◽  
Tunel Staining ◽  
Mineral Density ◽  
Vertebral Osteoporosis ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration

Abstract Background Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of nucleus pulposus (NP). Raloxifene (RAL) could delay ASDD by inhibiting NP apoptosis. Methods An ASDD rat model was established by ovariectomy (OVX) and posterolateral spinal fusion (PLF) on levels 4–5 of the lumbar vertebrae. Rats in the treatment groups were administered 1 mg/kg/d RAL by gavage for 12 weeks, following which, all animals were euthanized. Lumbar fusion, apoptosis, ASDD, and vertebrae micro-architecture were evaluated. Results RAL maintained intervertebral disk height (DHI), delayed vertebral osteoporosis, reduced histological score, and inhibited apoptosis. The OVX+PLF+RAL group revealed upregulated expression of aggrecan and B-cell lymphoma-2 (bcl2), as well as significantly downregulated expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), metalloproteinase-13 (MMP-13), caspase-3, BCL2-associated X (bax), and transferase dUTP nick end labeling (TUNEL) staining. Micro-computed tomography (Micro-CT) analysis revealed higher bone volume fraction (BV/TV), bone mineral density (BMD), and trabecular number (Tb.N), and lower trabecular separation (Tb.Sp) in OVX+PLF+RAL group than in the OVX+PLF group. Conclusions RAL can postpone ASDD development in OVX rats through inhibiting extracellular matrix metabolic imbalance, NP cell apoptosis, and vertebral osteoporosis. These findings showed RAL as a potential therapeutic target for ASDD.

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration

2011 ◽  
Vol 30 (6) ◽  
pp. 950-957 ◽  
Author(s):  
Lucas A. Smolders ◽  
Björn P. Meij ◽  
Frank M. Riemers ◽  
Ruud Licht ◽  
Richard Wubbolts ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Intervertebral Disk ◽  
Canonical Wnt Signaling ◽  
Notochordal Cell ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Canonical Wnt

Magnetic Resonance Classification System of Cervical Intervertebral Disk Degeneration

2017 ◽  
Vol 30 (5) ◽  
pp. E547-E553 ◽  
Author(s):  
Akinobu Suzuki ◽  
Michael D. Daubs ◽  
Tetsuo Hayashi ◽  
Monchai Ruangchainikom ◽  
Chenjie Xiong ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Classification System ◽  
Intervertebral Disk ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration

scholarly journals Regulation of Chemokine Expression by Interleukin-1 in Human Intervertebral Disk Degeneration

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1319945-s-0032-1319945
Author(s):  
K. L. E. Phillips ◽  
N. Chiverton ◽  
G. Haddock ◽  
R. Bunning ◽  
A. Cross ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Intervertebral Disk ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Chemokine Expression

scholarly journals Advanced trends in magnetic resonance imaging in assessment of lumbar intervertebral degenerative disk disease

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Rania Sobhy Abou Khadrah ◽  
Mohamed F. Dawoud ◽  
Ashraf Ali Abo-Elsafa ◽  
Amr M. Elkilany
Keyword(s):  
Diffusion Coefficient ◽  
Negative Correlation ◽  
Early Stage ◽  
T2 Mapping ◽  
Intervertebral Disk ◽  
Intervertebral Disk Degeneration ◽  
Disk Degeneration ◽  
Apparent Diffusion ◽  
Adc Values

Abstract Background T2 mapping and DWI are newly quantitated method for disk degeneration assessment; they were used in the determination of an early stage of intervertebral disk degeneration. T2 mapping was quantitatively sensitive for detecting the early stage and aging-related changes in intervertebral disk degeneration. Furthermore, T2 mapping and apparent diffusion coefficient values (ADC) in lumbar intervertebral disks indirectly correlated with the Pfirrmann grades in IVDD and age-related disk degeneration. The aim of this study is to evaluate the sensitivity of T2 mapping and apparent diffusion coefficient in the determination of an early stage of intervertebral disk degeneration. Results T2 relaxometry values were found to decrease with the increased disk degeneration except in grade V where it was found to be increased again. There was a negative correlation between T2 values and semi-quantitative grading (Pfirrmann Grading) of disk degeneration and T2 values were significantly different when comparing grade I to V. A T2 value of nucleus pulposus (NP) was more sensitive than annulus fibrosus (AF) and entire of the disk. ADC values were found to decrease with the increased degree of disk degeneration; there was a weakly significant negative correlation between age and T2 mapping values, ADC values of nucleus pulposus, and entire of disk. Conclusion T2 mapping was significantly different when comparing grade I to V while ADC value had a significant weak negative correlation with age, so T2 mapping and to a little extent ADC can be used for quantitative analysis of early disk generation seeking for early diagnosis and better management.

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