Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats

One of the most common neurological disorders, which occurs among 1% of the population worldwide, is epilepsy. Therapeutic failure is common with epilepsy and nearly about 30% of patients fall in this category. Seizure suppression should not be the only goal while treating epilepsy but associated comorbidities, which can further worsen the condition, should also be considered. Treatment of such comorbidities such as depression, anxiety, cognition, attention deficit hyperactivity disorder and, various other disorders which co-exist with epilepsy or are caused due to epilepsy should also be treated. Novel targets or the existing targets are needed to be explored for the dual mechanism which can suppress both the disease and the comorbidity. New therapeutic targets such as IDO, nNOS, PAR1, NF-κb are being explored for their role in epilepsy and various comorbidities. This review explores recent therapeutic targets for the treatment of comorbidities associated with epilepsy.

Download Full-text

IA09 Identification of New Therapeutic Targets in Non-Small Cell Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2019.12.010 ◽

2020 ◽

Vol 15 (2) ◽

pp. S4

Author(s):

K.A. O'Donnell

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Therapeutic Targets ◽

Small Cell ◽

Small Cell Lung ◽

New Therapeutic Targets

Download Full-text

Melanin production in coelomycetous agents of black grain eumycetoma

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/traa168 ◽

2021 ◽

Author(s):

Wilson Lim ◽

Florianne Parel ◽

Sybren de Hoog ◽

Annelies Verbon ◽

Wendy W J van de Sande

Keyword(s):

Fungal Infection ◽

Therapeutic Targets ◽

Biosynthetic Pathways ◽

Melanin Synthesis ◽

Melanin Production ◽

Causative Agents ◽

New Therapeutic Targets

Abstract Background Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets. Method Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors. Results In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis. Conclusion Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.

Download Full-text