scholarly journals Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals

2020 ◽  
Vol 8 ◽  
Author(s):  
Meng Zhang ◽  
Yanhui Zhai ◽  
Sheng Zhang ◽  
Xiangpeng Dai ◽  
Ziyi Li
Keyword(s):  
Stem Cell ◽  
Embryonic Development ◽  
Cell Fate ◽  
Early Embryonic Development ◽  
Stem Cell Fate ◽  
Cell Fate Decisions

scholarly journals Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate

2020 ◽  
Author(s):  
Kira Allmeroth ◽  
Christine S. Kim ◽  
Andrea Annibal ◽  
Andromachi Pouikli ◽  
Carlos Andrés Chacón-Martínez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Fate ◽  
Protein Biosynthesis ◽  
Mrna Translation ◽  
Stem Cell Differentiation ◽  
List Type ◽  
Stem Cell Fate ◽  
Cell Fate Decisions ◽  
Hair Follicle Stem Cell

AbstractStem cell differentiation is accompanied by an increase in mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure. Here, we investigated the function of polyamines in stem cell fate decisions using hair follicle stem cell (HFSC) organoids. HFSCs showed lower translation rates than progenitor cells, and a forced suppression of translation by direct targeting of the ribosome or through specific depletion of natural polyamines elevated stemness. In addition, we identified N1-acetylspermidine as a novel parallel regulator of cell fate decisions, increasing proliferation without reducing translation. Overall, this study delineates the diverse routes of polyamine metabolism-mediated regulation of stem cell fate decisions.Key PointsLow mRNA translation rates characterize hair follicle stem cell (HFSC) stateDepletion of natural polyamines enriches HFSCs via reduced translationN1-acetylspermidine promotes HFSC state without reducing translationN1-acetylspermidine expands the stem cell pool through elevated proliferation

Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters

EMBO Reports ◽  
2021 ◽  
Author(s):  
Shang‐Kun Dai ◽  
Pei‐Pei Liu ◽  
Hong‐Zhen Du ◽  
Xiao Liu ◽  
Ya‐Jie Xu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Stem Cell Fate ◽  
Cell Fate Decisions

scholarly journals mRNA modification orchestrates cancer stem cell fate decisions

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Weicheng Liang ◽  
Zexiao Lin ◽  
Cong Du ◽  
Dongbo Qiu ◽  
Qi Zhang
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Cell Fate Decisions

scholarly journals Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions

PLoS Genetics ◽  
2011 ◽  
Vol 7 (6) ◽  
pp. e1002130 ◽  
Author(s):  
Kian Leong Lee ◽  
Sandy Keat Lim ◽  
Yuriy Lvovich Orlov ◽  
Le Yau Yit ◽  
Henry Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Fate ◽  
Embryonic Stem ◽  
Stem Cell Fate ◽  
Cell Fate Decisions ◽  
Activin Signaling
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