scholarly journals The Mechanics of Mitotic Cell Rounding

2020 ◽  
Vol 8 ◽  
Author(s):  
Anna V. Taubenberger ◽  
Buzz Baum ◽  
Helen K. Matthews
Keyword(s):  
Mitotic Cell ◽  
Cell Rounding

scholarly journals Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning

2020 ◽  
Vol 133 (6) ◽  
pp. jcs235895
Author(s):  
Ritu Garg ◽  
Chuay-Yeng Koo ◽  
Elvira Infante ◽  
Caterina Giacomini ◽  
Anne J. Ridley ◽  
...  
Keyword(s):  
Mitotic Cell ◽  
Spindle Positioning ◽  
Cell Rounding

scholarly journals Mitotic cell rounding and epithelial thinning regulate lumen growth and shape

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Esteban Hoijman ◽  
Davide Rubbini ◽  
Julien Colombelli ◽  
Berta Alsina
Keyword(s):  
Mitotic Cell ◽  
Cell Rounding

Mitotic cell rounding accelerates epithelial invagination

Nature ◽  
2013 ◽  
Vol 494 (7435) ◽  
pp. 125-129 ◽  
Author(s):  
Takefumi Kondo ◽  
Shigeo Hayashi
Keyword(s):  
Mitotic Cell ◽  
Cell Rounding

scholarly journals Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Are Activated in Mitosis and Contribute to Mitotic Cell Rounding and Spindle Positioning

2011 ◽  
Vol 286 (34) ◽  
pp. 30161-30170 ◽  
Author(s):  
Rachael L. Wojtala ◽  
Ignatius A. Tavares ◽  
Penny E. Morton ◽  
Ferran Valderrama ◽  
N. Shaun B. Thomas ◽  
...  
Keyword(s):  
Mitotic Cell ◽  
Spindle Positioning ◽  
Cell Rounding

scholarly journals Inversin modulates the cortical actin network during mitosis

2013 ◽  
Vol 305 (1) ◽  
pp. C36-C47 ◽  
Author(s):  
Michael E. Werner ◽  
Heather H. Ward ◽  
Carrie L. Phillips ◽  
Caroline Miller ◽  
Vincent H. Gattone ◽  
...  
Keyword(s):  
Cell Division ◽  
Mammalian Cells ◽  
Cyst Formation ◽  
Mitotic Cell ◽  
Mouse Embryos ◽  
Cortical Actin ◽  
Division Plane ◽  
Spindle Positioning ◽  
Actin Organization ◽  
Cell Rounding

Mutations in inversin cause nephronophthisis type II, an autosomal recessive form of polycystic kidney disease associated with situs inversus, dilatation, and kidney cyst formation. Since cyst formation may represent a planar polarity defect, we investigated whether inversin plays a role in cell division. In developing nephrons from inv−/− mouse embryos we observed heterogeneity of nuclear size, increased cell membrane perimeters, cells with double cilia, and increased frequency of binuclear cells. Depletion of inversin by siRNA in cultured mammalian cells leads to an increase in bi- or multinucleated cells. While spindle assembly, contractile ring formation, or furrow ingression appears normal in the absence of inversin, mitotic cell rounding and the underlying rearrangement of the cortical actin cytoskeleton are perturbed. We find that inversin loss causes extensive filopodia formation in both interphase and mitotic cells. These cells also fail to round up in metaphase. The resultant spindle positioning defects lead to asymmetric division plane formation and cell division. In a cell motility assay, fibroblasts isolated from inv−/− mouse embryos migrate at half the speed of wild-type fibroblasts. Together these data suggest that inversin is a regulator of cortical actin required for cell rounding and spindle positioning during mitosis. Furthermore, cell division defects resulting from improper spindle position and perturbed actin organization contribute to altered nephron morphogenesis in the absence of inversin.

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