scholarly journals Structural Paradigms in the Recognition of the Nucleosome Core Particle by Histone Lysine Methyltransferases

2020 ◽  
Vol 8 ◽  
Author(s):  
Ashley Janna ◽  
Hossein Davarinejad ◽  
Monika Joshi ◽  
Jean-Francois Couture
Keyword(s):  
Core Particle ◽  
Nucleosome Core Particle ◽  
Nucleosome Core ◽  
Histone Lysine ◽  
Lysine Methyltransferases ◽  
Histone Lysine Methyltransferases

scholarly journals Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

2020 ◽  
Vol 56 (20) ◽  
pp. 3039-3042 ◽  
Author(s):  
Abbas H. K. Al Temimi ◽  
Paul B. White ◽  
Marcus J. M. Mulders ◽  
Nicole G. A. van der Linden ◽  
Richard H. Blaauw ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Histone Lysine ◽  
Lysine Methyltransferases ◽  
Geometrically Constrained ◽  
Histone Lysine Methyltransferases

Histone lysine methyltransferases (KMTs) exhibit substrate specificity for lysine and its geometrically constrained mimics.

scholarly journals Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions

2001 ◽  
Vol 20 (18) ◽  
pp. 5207-5218 ◽  
Author(s):  
Cindy L. White ◽  
Robert K. Suto ◽  
Karolin Luger
Keyword(s):  
Core Particle ◽  
Nucleosome Core Particle ◽  
Nucleosome Core

Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation

2013 ◽  
Vol 16 (1) ◽  
pp. 70-82 ◽  
Author(s):  
Anastasia Spyropoulou ◽  
Antonios Gargalionis ◽  
Georgia Dalagiorgou ◽  
Christos Adamopoulos ◽  
Kostas A. Papavassiliou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Colony Formation ◽  
Histone Lysine ◽  
Lysine Methyltransferases ◽  
Histone Lysine Methyltransferases

Helical repeat of DNA in the nucleosome core particle

2000 ◽  
Vol 28 (4) ◽  
pp. 373-376 ◽  
Author(s):  
R. Negri ◽  
M. Buttinelli ◽  
G. Panetta ◽  
V. De Arcangelis ◽  
E. Di Mauro ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Linker Histone ◽  
Core Particle ◽  
Nucleosome Core Particle ◽  
Apparent Paradox ◽  
Nucleosome Core ◽  
Nucleosome Core Particles ◽  
High Affinity Site ◽  
Hydroxyl Radical Cleavage ◽  
Radical Cleavage

Although the crystal structure of nucleosome core particle is essentially symmetrical in the vicinity of the dyad, the linker histone binds asymmetrically in this region to select a single high-affinity site from potentially two equivalent sites. To try to resolve this apparent paradox we mapped to base-pair resolution the dyads and rotational settings of nucleosome core particles reassembled on synthetic tandemly repeating 20 bp DNA sequences. In agreement with previous observations, we observed (1) that the helical repeat on each side of the dyad cluster is 10 bp maintaining register with the sequence repeat and (2) that this register changes by 2 bp in the vicinity of the dyad. The additional 2 bp required to effect the change in the rotational settings is accommodated by an adjustment immediately adjacent to the dyad. At the dyad the hydroxyl radical cleavage is asymmetric and we suggest that the inferred structural asymmetry could direct the binding of the linker histone to a single preferred site.

scholarly journals 3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM

2016 ◽  
Vol 44 (17) ◽  
pp. 8013-8019 ◽  
Author(s):  
Eugene Y.D. Chua ◽  
Vinod K. Vogirala ◽  
Oviya Inian ◽  
Andrew S.W. Wong ◽  
Lars Nordenskiöld ◽  
...  
Keyword(s):  
Phase Plate ◽  
Core Particle ◽  
Nucleosome Core Particle ◽  
Nucleosome Core

The Crystal Structure of the Nucleosome Core Particle by Contrast Variation

1984 ◽  
pp. 105-117
Author(s):  
Graham A. Bentley ◽  
John T. Finch ◽  
Anita Lewit-Bentley ◽  
Michel Roth
Keyword(s):  
Crystal Structure ◽  
Core Particle ◽  
Nucleosome Core Particle ◽  
Contrast Variation ◽  
Nucleosome Core
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