rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2020.00568 ◽

2020 ◽

Vol 8 ◽

Cited By ~ 2

Author(s):

Jinbae Son ◽

Katherine M. Hannan ◽

Gretchen Poortinga ◽

Nadine Hein ◽

Donald P. Cameron ◽

...

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Transcription Inhibitor ◽

Polymerase I

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The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461

Australian Journal of Chemistry ◽

10.1071/ch21049 ◽

2021 ◽

Author(s):

Madushani Amarasiri ◽

Yen Vo ◽

Michael G. Gardiner ◽

Perlita Poh ◽

Priscilla Soo ◽

...

Keyword(s):

Rna Polymerase ◽

Biological Evaluation ◽

Rna Polymerase I ◽

Transcription Inhibitor ◽

Polymerase I ◽

Synthesis And Biological Evaluation ◽

Derivatives Of

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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Cancer Discovery ◽

10.1158/2159-8290.cd-18-1455 ◽

2019 ◽

Vol 9 (8) ◽

pp. 1036-1049 ◽

Cited By ~ 30

Author(s):

Amit Khot ◽

Natalie Brajanovski ◽

Donald P. Cameron ◽

Nadine Hein ◽

Kylee H. Maclachlan ◽

...

Keyword(s):

Rna Polymerase ◽

Phase I ◽

Dose Escalation ◽

Rna Polymerase I ◽

Dose Escalation Study ◽

Transcription Inhibitor ◽

Polymerase I

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Faculty Opinions recommendation of TFIIH plays an essential role in RNA polymerase I transcription.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006376.79958 ◽

2002 ◽

Author(s):

Lucio Comai

Keyword(s):

Rna Polymerase ◽

Essential Role ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of RNA polymerase I propagates unidirectional spreading of rDNA silent chromatin.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1011190.179713 ◽

2003 ◽

Author(s):

Lucio Comai

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Silent Chromatin ◽

Polymerase I

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Faculty Opinions recommendation of In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012188.184671 ◽

2003 ◽

Author(s):

Jonathan R Warner

Keyword(s):

Saccharomyces Cerevisiae ◽

Rna Polymerase ◽

Loading Rate ◽

Rna Polymerase I ◽

Rrna Synthesis ◽

Polymerase I ◽

Active Genes

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Faculty Opinions recommendation of RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021818.248652 ◽

2004 ◽

Author(s):

Daniel Reines

Keyword(s):

Saccharomyces Cerevisiae ◽

Rna Polymerase ◽

Rna Polymerase I ◽

Subunit Exchange ◽

Polymerase I

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Faculty Opinions recommendation of Cdc14 inhibits transcription by RNA polymerase I during anaphase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1157580.617770 ◽

2009 ◽

Author(s):

Andrew D Sharrocks

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13427964.14802063 ◽

2011 ◽

Author(s):

Katsuhiko Murakami ◽

Sung-hoon Jun

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Basal Transcription ◽

Basal Transcription Machinery ◽

Transcription Machinery ◽

Polymerase I

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Faculty Opinions recommendation of RNA polymerase I structure and transcription regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718153960.793491178 ◽

2014 ◽

Author(s):

Sui Huang

Keyword(s):

Rna Polymerase ◽

Transcription Regulation ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726489647.793521907 ◽

2016 ◽

Author(s):

Ian Willis

Keyword(s):

Rna Polymerase ◽

Transcription Initiation ◽

Rna Polymerase I ◽

Polymerase I

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