scholarly journals Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

2020 ◽  
Vol 8 ◽  
Author(s):  
Jiao Gong ◽  
Yusheng Jie ◽  
Cuicui Xiao ◽  
Wenying Zhou ◽  
Xinhua Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

scholarly journals MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Bin Yang ◽  
Chunping Wang ◽  
Hui Xie ◽  
Yiwu Wang ◽  
Jiagan Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Notch Signaling Pathway ◽  
Advanced Hepatocellular Carcinoma ◽  
Targeted Agents ◽  
Mesenchymal Transition ◽  
Molecular Targeted Agents ◽  
Hcc Cells

Abstract Molecular targeted agents, such as sorafenib, remain the only choice of an antitumor drug for the treatment of advanced hepatocellular carcinoma (HCC). The Notch signaling pathway plays central roles in regulating the cellular injury/stress response, anti-apoptosis, or epithelial–mesenchymal transition process in HCC cells, and is a promising target for enhancing the sensitivity of HCC cells to antitumor agents. The ADAM metalloprotease domain-17 (ADAM-17) mediates the cleavage and activation of Notch protein. In the present study, microRNA-3163 (miR-3163), which binds to the 3′-untranslated region of ADAM-17, was screened using online methods. miRDB and pre-miR-3163 sequences were prepared into lentivirus particles to infect HCC cells. miR-3163 targeted ADAM-17 and inhibited the activation of the Notch signaling pathway. Infection of HCC cells with miR-3163 enhanced their sensitivity to molecular targeted agents, such as sorafenib. Therefore, miR-3163 may contribute to the development of more effective strategies for the treatment of advanced HCC.

scholarly journals The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma

2019 ◽  
Vol 10 (6) ◽  
pp. 1570-1579 ◽  
Author(s):  
Qinfeng Huang ◽  
Junhong Li ◽  
Jinghui Zheng ◽  
Ailing Wei
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

Notch signaling pathway regulates P57KIP2 expression in human hepatocellular carcinoma

2009 ◽  
Vol 41 (3) ◽  
pp. A16
Author(s):  
M. Minguzzi ◽  
C. Giovannini ◽  
F. Fornari ◽  
L. Gramantieri ◽  
P. Chieco ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
Human Hepatocellular Carcinoma

scholarly journals GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17

2020 ◽  
Vol 17 ◽  
pp. 332-349 ◽  
Author(s):  
Subbroto Kumar Saha ◽  
Hye Yeon Choi ◽  
Gwang-Mo Yang ◽  
Polash Kumar Biswas ◽  
Kyeongseok Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Direct Interaction ◽  
Notch Signaling Pathway

scholarly journals Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway

2012 ◽  
Vol 27 (4) ◽  
pp. 1170-1176 ◽  
Author(s):  
FAN WANG ◽  
HAIYAN ZHOU ◽  
YUZHEN YANG ◽  
XIUMEI XIA ◽  
QIAN SUN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
X Protein ◽  
B Virus
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