scholarly journals Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease

2020 ◽  
Vol 8 ◽  
Author(s):  
Linda Anna Michelle Kulka ◽  
Pia-Victoria Fangmann ◽  
Diana Panfilova ◽  
Heidi Olzscha
Keyword(s):  
Quality Control ◽  
Precision Medicine ◽  
Control Systems ◽  
Malignant Disease ◽  
Protein Quality ◽  
Hdac Inhibitors ◽  
Protein Quality Control

scholarly journals Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

2013 ◽  
Vol 41 (6) ◽  
pp. 1483-1488 ◽  
Author(s):  
Jaime L. Schneider ◽  
Ana Maria Cuervo
Keyword(s):  
Quality Control ◽  
Neurodegenerative Diseases ◽  
Disease Progression ◽  
Control Systems ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Dual Role ◽  
Selective Degradation ◽  
Main Components ◽  
Chaperone Mediated Autophagy

The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms, are key in the fight against the proteotoxicity that is often associated with severe neurodegenerative diseases. However, in recent years, a new theme has emerged which suggests that components of protein quality-control pathways are often targets of the toxic effects of pathogenic proteins and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as ‘saviour’ and ‘victim’ in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic proteins in lysosomes.

scholarly journals ER-associated degradation: Protein quality control and beyond

2014 ◽  
Vol 204 (6) ◽  
pp. 869-879 ◽  
Author(s):  
Annamaria Ruggiano ◽  
Ombretta Foresti ◽  
Pedro Carvalho
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Protein Degradation ◽  
Control Systems ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Secretory Proteins ◽  
Toxic Species ◽  
Cellular Factors

Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up misfolded. Cells evolved protein quality control systems to ensure that these potentially toxic species are detected and eliminated. The best characterized of these pathways, the ER-associated protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the endoplasmic reticulum (ER). There is also increasing evidence that ERAD controls other ER-related functions through regulated degradation of certain folded ER proteins, further highlighting the role of ERAD in cellular homeostasis.

scholarly journals Oxidative Stress and Protein Quality Control Systems in the Aged Canine Brain as a Model for Human Neurodegenerative Disorders

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Mariarita Romanucci ◽  
Leonardo Della Salda
Keyword(s):  
Quality Control ◽  
Control Systems ◽  
Protein Quality ◽  
Treatment Strategies ◽  
Protein Quality Control ◽  
Ubiquitin Proteasome System ◽  
Canine Model ◽  
Canine Brain ◽  
Age Related ◽  
Novel Treatment Strategies

Aged dogs are considered the most suitable spontaneous animal model for studying normal aging and neurodegenerative diseases. Elderly canines naturally develop cognitive dysfunction and neuropathological hallmarks similar to those seen in humans, especially Alzheimer’s disease-like pathology. Pet dogs also share similar living conditions and diets to humans. Oxidative damage accumulates in the canine brain during aging, making dogs a valid model for translational antioxidant treatment/prevention studies. Evidence suggests the presence of detective protein quality control systems, involving ubiquitin-proteasome system (UPS) and Heat Shock Proteins (HSPs), in the aged canine brain. Further studies on the canine model are needed to clarify the role of age-related changes in UPS activity and HSP expression in neurodegeneration in order to design novel treatment strategies, such as HSP-based therapies, aimed at improving chaperone defences against proteotoxic stress affecting brain during aging.

Protein quality control systems associated with no-go and nonstop mRNA surveillance in yeast

2013 ◽  
Vol 19 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Ryo Matsuda ◽  
Ken Ikeuchi ◽  
Sene Nomura ◽  
Toshifumi Inada
Keyword(s):  
Quality Control ◽  
Control Systems ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Mrna Surveillance
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