scholarly journals Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche

2020 ◽  
Vol 8 ◽  
Author(s):  
Francesco Bellanti ◽  
Giuseppe Pannone ◽  
Nicola Tartaglia ◽  
Gaetano Serviddio
Keyword(s):  
Immune Response ◽  
Progenitor Cell ◽  
Redox Control ◽  
Hepatic Progenitor Cell ◽  
Cell Niche

The canine hepatic progenitor cell niche: Molecular characterisation in health and disease

2014 ◽  
Vol 201 (3) ◽  
pp. 345-352 ◽  
Author(s):  
H.S. Kruitwagen ◽  
B. Spee ◽  
C.S. Viebahn ◽  
H.B. Venema ◽  
L.C. Penning ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Molecular Characterisation ◽  
Hepatic Progenitor Cell ◽  
Health And Disease ◽  
Cell Niche

scholarly journals Immunohistochemical characterisation of the hepatic stem cell niche in feline hepatic lipidosis: a preliminary morphological study

2018 ◽  
Vol 21 (2) ◽  
pp. 165-172
Author(s):  
Chiara Valtolina ◽  
Joris H Robben ◽  
Robert P Favier ◽  
Jan Rothuizen ◽  
Guy CM Grinwis ◽  
...  
Keyword(s):  
Kupffer Cells ◽  
Morphological Study ◽  
Progenitor Cell ◽  
Smooth Muscle Actin ◽  
Spatial Association ◽  
Cell Types ◽  
Hepatic Progenitor Cell ◽  
Hepatic Lipidosis ◽  
Alpha Smooth Muscle Actin ◽  
Cell Niche

Objectives The aim of this study was to describe the cellular and stromal components of the hepatic progenitor cell niche in feline hepatic lipidosis (FHL). Methods Immunohistochemical staining for the progenitor/bile duct marker (K19), activated Kupffer cells (MAC387), myofibroblasts (alpha-smooth muscle actin [α-SMA]) and the extracellular matrix component laminin were used on seven liver biopsies of cats with FHL and three healthy cats. Double immunofluorescence stainings were performed to investigate co-localisation of different cell types in the hepatic progenitor cell (HPC) niche. Results HPCs, Kupffer cells, myofibroblasts and laminin deposition were observed in the liver samples of FHL, although with variability in the expression and positivity of the different immunostainings between different samples. When compared with the unaffected cats where K19 positivity and minimal α-SMA and laminin positivity were seen mainly in the portal area, in the majority of FHL samples K19 and α-SMA-positive cells and laminin positivity were seen also in the periportal and parenchymatous area. MAC387-positive cells were present throughout the parenchyma. Conclusions and relevance This is a preliminary morphological study to describe the activation and co-localisation of components of the HPC niche in FHL. Although the HPC niche in FHL resembles that described in hepatopathies in dogs and in feline lymphocytic cholangitis, the expression of K19, α-SMA, MAC387 and lamin is more variable in FHL, and a common pattern of activation could not be established. Nevertheless, when HPCs were activated, a spatial association between HPCs and their niche could be demonstrated.

scholarly journals Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis

2017 ◽  
Vol 20 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Corma MA Otte ◽  
Chiara Valtolina ◽  
Sandra Vreman ◽  
Siobhan Hubers ◽  
Monique E van Wolferen ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Progenitor Cell ◽  
Treatment Options ◽  
Hepatic Progenitor Cells ◽  
Hepatic Progenitor Cell ◽  
Immunohistochemical Markers ◽  
Enhanced Expression ◽  
Liver Biopsies ◽  
Cell Niche ◽  
Formalin Fixed

Objectives The aim of the study was to compare the hepatic progenitor cell niche in healthy feline livers and the liver tissue of cats with lymphocytic cholangitis. Methods Immunohistochemical stainings for vimentin, laminin, beta (β)-catenin and Notch1 intracellular domain (NICD) were used on formalin-fixed liver biopsies from affected (n = 12) and unaffected cats (n = 2). Results All immunohistochemical markers used were expressed in more cells, or more intensely, in the liver tissue of cats with lymphocytic cholangitis than in the liver tissue of unaffected cats. Conclusions and relevance Enhanced expression of vimentin, laminin, cytoplasmic/nuclear β-catenin and NICD in liver biopsies from cats with lymphocytic cholangitis indicates that the hepatic progenitor cell (HPC) niche is remodelled and activated. HPCs might provide insights into new regenerative treatment options for lymphocytic cholangitis in cats in the future.

Manipulation of liver regeneration with macrophages to influence the hepatic progenitor cell niche

The Lancet ◽  
2013 ◽  
Vol 381 ◽  
pp. S23 ◽  
Author(s):  
TG Bird ◽  
L Boutler ◽  
A Cole ◽  
S Lorenzini ◽  
WY Lu ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Hepatic Progenitor Cell ◽  
Cell Niche

scholarly journals Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche

2014 ◽  
Vol 10 (1) ◽  
Author(s):  
Baukje A Schotanus ◽  
Hedwig S Kruitwagen ◽  
Ted SGAM van den Ingh ◽  
Monique E van Wolferen ◽  
Jan Rothuizen ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Notch Signalling ◽  
Hepatic Progenitor Cell ◽  
Cell Niche

530 CHARACTERISATION OF THE LIVER PROGENITOR CELL NICHE

2008 ◽  
Vol 48 ◽  
pp. S199
Author(s):  
B. Spee ◽  
S. Vanderborght ◽  
M. Komuta ◽  
G. Carpino ◽  
B.A. Schotanus ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Niche ◽  
Liver Progenitor Cell

Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study

2018 ◽  
Vol 32 (3) ◽  
pp. e13203 ◽  
Author(s):  
Regina Cheuk-lam Lo ◽  
Kristy Kwan-shuen Chan ◽  
Carmen Oi-ning Leung ◽  
Irene Oi-lin Ng
Keyword(s):  
Progenitor Cell ◽  
Immunohistochemical Study ◽  
Acute Cellular Rejection ◽  
Hepatic Progenitor Cell ◽  
Cell Markers ◽  
Cellular Rejection
Sign in / Sign up

Export Citation Format

Share Document