scholarly journals MiR-506 Targets UHRF1 to Inhibit Colorectal Cancer Proliferation and Invasion via the KISS1/PI3K/NF-κB Signaling Axis

2019 ◽  
Vol 7 ◽  
Author(s):  
Yilin Lin ◽  
Zhihua Chen ◽  
Yan Zheng ◽  
Yisu Liu ◽  
Ji Gao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Proliferation ◽  
Signaling Axis ◽  
Proliferation And Invasion

scholarly journals miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Meiyuan Yang ◽  
Xiaoli Tang ◽  
Zheng Wang ◽  
Xiaoqing Wu ◽  
Dong Tang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Underlying Mechanism ◽  
Cell Counting ◽  
Binding Motif ◽  
Cancer Proliferation ◽  
Qrt Pcr ◽  
Sirna Knockdown ◽  
Proliferation And Invasion ◽  
Hct116 Cells

Abstract Colorectal cancer (CRC) is the third most common malignant tumor worldwide and is a serious threat to human health. MicroRNAs (miRNAs) play a key role in oncogenesis and cancer progression. MiRNA-125 (miR-125) is an important miRNA that is dysregulated in several kinds of cancers. Thus, we investigated the expression and effects of miR-125 and Transcriptional co-activator with PDZ-binding motif (TAZ) for a better understanding of the underlying mechanism of tumor progression in CRC, which may provide an emerging biomarker for diagnosis and treatment of CRC. We measured the expression levels of miR-125 in CRC tissues, adjacent tissues, and cell lines (e.g. HCT116, SW480, FHC) by quantitative real-time polymerase chain reaction (qRT-PCR). The effect of miR-125 on proliferation and invasion in CRC cells was detected by Cell Counting Kit-8 (CCK-8), clone formation assay, and transwell assay. Western blotting and qRT-PCR were used to investigate the expression of TAZ after knocking down miR-125 in HCT116 cells or overexpressing miR-125 in SW480 cells. MiR-125 was significantly down-regulated in CRC compared with pericarcinomatous tissue from 18 patients. An miR-125 inhibitor promoted CRC cell proliferation and invasion, while miR-125 mimic had the opposite effect. Moreover, we found that TAZ was an miR-125 target and the siRNA knockdown of TAZ could reverse the effect of the miR-125 inhibitor on proliferation and invasion in HCT116 cells. The present study shows that miR-125 suppresses CRC proliferation and invasion by targeting TAZ.

scholarly journals The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147

2018 ◽  
Author(s):  
Yuqin Pan ◽  
Huiling Sun ◽  
Xiuxiu Hu ◽  
Bangshun He ◽  
Xiangxiang Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Proliferation ◽  
Inhibitory Role ◽  
Proliferation And Invasion

Epigenetic silencing of NDRG2 promotes colorectal cancer proliferation and invasion

2015 ◽  
Vol 31 (1) ◽  
pp. 164-171 ◽  
Author(s):  
Sung Noh Hong ◽  
Sung Jin Kim ◽  
Eun-Ran Kim ◽  
Dong Kyung Chang ◽  
Young-Ho Kim
Keyword(s):  
Colorectal Cancer ◽  
Epigenetic Silencing ◽  
Cancer Proliferation ◽  
Proliferation And Invasion

scholarly journals MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a

2015 ◽  
Vol 356 (2) ◽  
pp. 669-675 ◽  
Author(s):  
Jiaojiao Zhou ◽  
Mengwen Zhang ◽  
Yanqing Huang ◽  
Lin Feng ◽  
Hailong Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Proliferation ◽  
Proliferation And Invasion

ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras–ERK signaling

2018 ◽  
Vol 234 (6) ◽  
pp. 8899-8907 ◽  
Author(s):  
Dehua Zhu ◽  
Jianping Zhou ◽  
Jinbo Zhao ◽  
Guiyang Jiang ◽  
Xiupeng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Erk Signaling ◽  
Cancer Proliferation ◽  
Proliferation And Invasion

The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect

Oncogene ◽  
2018 ◽  
Vol 38 (4) ◽  
pp. 483-496 ◽  
Author(s):  
Qingguo Li ◽  
Ping Wei ◽  
Jitao Wu ◽  
Meng Zhang ◽  
Guichao Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Cancer Proliferation ◽  
Signaling Axis ◽  
The Warburg Effect

Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4605-4610 ◽  
Author(s):  
Atena Soleimani ◽  
Farzad Rahmani ◽  
Gordon A. Ferns ◽  
Mikhail Ryzhikov ◽  
Amir Avan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Current Knowledge ◽  
Akt Signaling ◽  
Tumor Tissues ◽  
Radio Therapy ◽  
Signaling Axis ◽  
Cancer Tumor ◽  
Novel Biomarkers

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

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