scholarly journals Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information

2019 ◽  
Vol 7 ◽  
Author(s):  
Upasna Sharma
Keyword(s):  
Intergenerational Transmission ◽  
Small Rnas ◽  
Epigenetic Information ◽  
Offspring Health

scholarly journals Sperm tsRNAs and acquired metabolic disorders

2016 ◽  
Vol 230 (3) ◽  
pp. F13-F18 ◽  
Author(s):  
Menghong Yan ◽  
Qiwei Zhai
Keyword(s):  
Dna Methylation ◽  
Environmental Factors ◽  
Intergenerational Transmission ◽  
Small Rnas ◽  
Metabolic Disorders ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Metabolic Changes ◽  
Epigenetic Information ◽  
Non Coding Rnas

Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as DNA methylation, histone modification and small non-coding RNAs. Recent evidence shows that sperm tRNA-derived small RNAs (tsRNAs) as a type of paternal epigenetic information carrier may mediate intergenerational inheritance. In this review, we provide current knowledge of a father’s influence on metabolic disorders in subsequent generations and discuss the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission.

The role of multiple attachments in intergenerational transmission of child sexual abuse among male victims

2020 ◽  
pp. 104864
Author(s):  
Raphaële Miljkovitch ◽  
Camille Danner-Touati ◽  
Isabelle Gery ◽  
Annie Bernier ◽  
Aino Sirparanta ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Child Sexual Abuse ◽  
Intergenerational Transmission ◽  
Male Victims

scholarly journals MicroRNAs: Biological Regulators in Pathogen–Host Interactions

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 113 ◽  
Author(s):  
Stephanie Maia Acuña ◽  
Lucile Maria Floeter-Winter ◽  
Sandra Marcia Muxel
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
Small Rnas ◽  
Immune Cell ◽  
Fine Tuning ◽  
Biological Processes ◽  
Host Interactions ◽  
The Past ◽  
Biological Aspects

An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group of noncoding small RNAs, have emerged as functionally significant regulatory molecules with the significant capability of fine-tuning biological processes. The important role of miRNAs in inflammation and immune responses is highlighted by studies in which the regulation of miRNAs in the host was shown to be related to infectious diseases and associated with the eradication or susceptibility of the infection. Here, we review the biological aspects of microRNAs, focusing on their roles as regulators of gene expression during pathogen–host interactions and their implications in the immune response against Leishmania, Trypanosoma, Toxoplasma, and Plasmodium infectious diseases.

The role of maternal nutrition during pregnancy in the intergenerational transmission of childhood adversity

2021 ◽  
pp. 105283
Author(s):  
Elnaz Vaghef-Mehrabany ◽  
Jenna C. Thomas-Argyriou ◽  
Erin D. Lewis ◽  
Catherine J. Field ◽  
Yanan Wang ◽  
...  
Keyword(s):  
Intergenerational Transmission ◽  
Maternal Nutrition ◽  
Childhood Adversity

scholarly journals The Intergenerational Transmission of Socioeconomic Advantage: Some Longitudinal Evidence

2021 ◽  
pp. 002205742199832
Author(s):  
Tony Cassidy ◽  
Marian McLaughlin ◽  
Eimear McDowell
Keyword(s):  
Socioeconomic Status ◽  
Psychosocial Factors ◽  
Intergenerational Transmission ◽  
Education System ◽  
Occupational Status ◽  
Academic Development ◽  
Academic Growth ◽  
Educational Opportunities ◽  
Single Solution

Intergenerational transmission of disadvantage remains a problem despite political and educational initiatives. This study explored the role of personality and psychosocial factors in occupational status in a survey of 383 participants (174 males and 209 females) over 39 years from age 16 to 55. Mother’s education, extraversion, and mastery motivation were the best predictors of current socioeconomic status. A focus on education and academic development as the single solution to social immobility has been ineffective. Instead a broader approach which includes realistic lifelong educational opportunities and an education system which enables socioemotional development as well as academic growth is recommended.

Intergenerational Transmission of Violence Among Substance-Abusing Chinese Parents: Roles of Detachment and Social Support

2021 ◽  
pp. 088626052110374
Author(s):  
Ruixin Cao ◽  
Hechun Li ◽  
Huiping Zhang
Keyword(s):  
Social Support ◽  
Child Abuse ◽  
Childhood Abuse ◽  
Intergenerational Transmission ◽  
Parenting Practices ◽  
Large Population ◽  
Substance Abusing ◽  
Abuse History ◽  
Intergenerational Transmission Of Violence

Despite a large population of registered people with drug addiction, child protection in substance-abusing families is a neglected issue in China. The present study aims to investigate the association between parents’ childhood abuse history and the risk of abusing their own children in substance-abusing Chinese families and also to examine the mediating role of detachment and moderating role of social support during the intergenerational transmission of abuse. A total of 173 men and 116 women were selected using cluster sampling from two compulsory drug rehabilitation centers in Jiangsu Province. Results indicated that one’s childhood abuse history was positively associated with the current perpetration of child abuse for both fathers and mothers. Detachment mediated the linkage between a history of childhood maltreatment and perpetration of child abuse in all types of abuse for both men and women except for women’s sexual abuse. Social support from family members buffered the intergenerational transmission of child abuse for fathers but not for mothers. Child maltreatment in substance-abusing families is an urgent issue that needs measures to prevent the intergenerational transmission of violence in China. Intervention programs could involve helping parents cope with their childhood abuse history through rebuilding secure attachment and facilitating social support for their parenting practices, especially for fathers.

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