Neuronal Migration Generates New Populations of Neurons That Develop Unique Connections, Physiological Properties and Pathologies

miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

eLife ◽

10.7554/elife.04263 ◽

2015 ◽

Vol 4 ◽

Cited By ~ 43

Author(s):

Eleonora Franzoni ◽

Sam A Booker ◽

Srinivas Parthasarathy ◽

Frederick Rehfeld ◽

Sabine Grosser ◽

...

Keyword(s):

Neuronal Migration ◽

Deleterious Effect ◽

Adult Stem Cell ◽

Cognitive Disorder ◽

Neuronal Morphology ◽

Intrinsic Excitability ◽

Electrophysiological Properties ◽

Physiological Properties ◽

Stem Cell Niches ◽

Cortical Lamination

miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that post-transcriptional mechanisms restrict miR-128 accumulation to post-mitotic neurons during mouse corticogenesis and in adult stem cell niches. Whereas premature miR-128 expression in progenitors for upper layer neurons leads to impaired neuronal migration and inappropriate branching, sponge-mediated inhibition results in overmigration. Within the upper layers, premature miR-128 expression reduces the complexity of dendritic arborization, associated with altered electrophysiological properties. We show that Phf6, a gene mutated in the cognitive disorder Börjeson-Forssman-Lehmann syndrome, is an important regulatory target for miR-128. Restoring PHF6 expression counteracts the deleterious effect of miR-128 on neuronal migration, outgrowth and intrinsic physiological properties. Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.

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LHRH neuronal migration from the transplanted olfactory placode to the spinal cord in chick embryo

Neuroscience Research ◽

10.1016/s0168-0102(00)81667-3 ◽

2000 ◽

Vol 38 ◽

pp. S137

Author(s):

S Murakami

Keyword(s):

Spinal Cord ◽

Chick Embryo ◽

Neuronal Migration ◽

Olfactory Placode

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Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration

Endocrine Abstracts ◽

10.1530/endoabs.38.oc1.2 ◽

2015 ◽

Author(s):

Sasha Howard ◽

Leo Guasti ◽

Gerard Ruiz-Babot ◽

Alessandra Mancini ◽

Alessia David ◽

...

Keyword(s):

Neuronal Migration ◽

Delayed Puberty

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IDENTIFICATION AND CHARACTERIZATION OF A PURPLE NONSULFUR BACTERIUM ISOLATED FROM COASTAL AREA OF HAI PHONG FOR USING IN PRODUCTION OF UNSATURATED FATTY ACID (OMEGA 6, 7, 9)

Vietnam Journal of Science and Technology ◽

10.15625/2525-2518/57/6/13711 ◽

2019 ◽

Vol 57 (6) ◽

pp. 665 ◽

Cited By ~ 1

Author(s):

Yen Thi Hoang ◽

Quynh Thi Thu Tran ◽

Ha Hoang Chu ◽

Tuyen Thi Do ◽

Thanh Tat Dang ◽

...

Keyword(s):

Fatty Acid ◽

Unsaturated Fatty Acid ◽

Unsaturated Fatty Acids ◽

Nitrogen Sources ◽

16S Rrna Analysis ◽

Rhodovulum Sulfidophilum ◽

Purple Nonsulfur Bacterium ◽

High Lipid ◽

Physiological Properties ◽

Omega 6

Purple nonsulfur bacteria are a group that has so much biotechnological applications, particularly in producing of functional food rich with unsaturated fatty acids. A purple nonsulfur bacterium (named HPB.6) was chosen based on its strong growth, high lipid and synthesis of unsaturated fatty acid (omega 6,7,9). Studying on basic biological characteristics showed that the cells of HPB.6 were observed as ovoid-rod shape, none motility, Gram negative staining. The diameter of single bacterium was about 0.8-1.0 µm. The cells divide by binary fission and had bacteriochlorophyll a (Bchl a). This bacterium grew well on medium with carbon and nitrogen sources such as acetate, succinate, pyruvate, butyrate, glutamate, arginine, leucine, tyrosine, alanine, methionine, threonine, glutamine, yeast extract and NH4Cl. This selected strain grew well on medium with salt concentrations from 1.5 - 6.0% (optimum 3%), pH from 5.0 to 8.0 (optimum at pH 6.5) and could withstand Na2S at 4.0 - 5.2 mM. Based on morphological, physiological properties and 16S rRNA analysis received demonstrated that HPB.6 strain belongs to the species Rhodovulum sulfidophilum.

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Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives Through a Combination of 8-Aminoquinoline Directed C–H Arylations and Transamidations

10.26434/chemrxiv.7925489.v1 ◽

2019 ◽

Author(s):

Michael Oschmann ◽

Linus Johansson Holm ◽

Oscar Verho

Keyword(s):

Small Molecule ◽

High Efficiency ◽

Synthetic Strategy ◽

Small Molecule Screening ◽

Physiological Properties ◽

Wide Range ◽

Directing Group ◽

Synthetic Sequence

Benzofurans are everywhere in nature and they have been extensively studied by medicinal chemists over the years because of their chemotherapeutic and physiological properties. Herein, we describe a strategy that can be used to access elaborate benzo-2-carboxamide derivatives, which involves a synthetic sequence of 8-aminoquinoline directed C–H arylations followed by transamidations. For the directed C–H arylations, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a two-step transamidation protocol. By bocylating the 8-aminoquinoline amide moiety of these products, it proved possible to activate them towards aminolysis with different amine nucleophiles. Interestingly, this aminolysis reaction was found to proceed efficiently without the need of any additional catalyst or additive. Given the high efficiency and modularity of this synthetic strategy, it constitute a very attractive approach for generating structurally-diverse collections of benzofuran derivatives for small molecule screening.

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