scholarly journals Mitotic Regulation by NEK Kinase Networks

2017 ◽  
Vol 5 ◽  
Author(s):  
Andrew M. Fry ◽  
Richard Bayliss ◽  
Joan Roig
Keyword(s):  
Mitotic Regulation

scholarly journals Physiological and Pathological Roles of Mammalian NEK7

2020 ◽  
Vol 11 ◽  
Author(s):  
Zhenzhen Sun ◽  
Wei Gong ◽  
Yue Zhang ◽  
Zhanjun Jia
Keyword(s):  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Major Function ◽  
Nlrp3 Inflammasome Activation ◽  
The Future ◽  
Potential Inhibitors ◽  
Mitotic Regulation

NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulation remain unclear. This review summarizes current advances in NEK7 research involving mitotic regulation, NLRP3 inflammasome activation, related diseases and potential inhibitors, which may provide new insights into the understanding and therapy of the diseases associated with NEK7, as well as the subsequent studies in the future.

scholarly journals Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kazuhiro Suzuki ◽  
Kosuke Sako ◽  
Kazuhiro Akiyama ◽  
Michitaka Isoda ◽  
Chiharu Senoo ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
C2h2 Zinc Finger ◽  
Consensus Motifs ◽  
Mitotic Regulation

Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

BioEssays ◽  
2003 ◽  
Vol 25 (2) ◽  
pp. 174-181 ◽  
Author(s):  
Kun Ping Lu ◽  
Yih-Cherng Liou ◽  
Inez Vincent
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitotic Regulation

scholarly journals Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization.

1996 ◽  
Vol 10 (19) ◽  
pp. 2389-2400 ◽  
Author(s):  
N Segil ◽  
M Guermah ◽  
A Hoffmann ◽  
R G Roeder ◽  
N Heintz
Keyword(s):  
Subcellular Localization ◽  
Mitotic Regulation

Mitotic regulation of protein phosphatases by the fission yeast sds22 protein

1993 ◽  
Vol 3 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Elisa M. Stone ◽  
Hiroyuki Yamano ◽  
Noriyuki Kinoshita ◽  
Mitsuhiro Yanagida
Keyword(s):  
Fission Yeast ◽  
Protein Phosphatases ◽  
Mitotic Regulation

scholarly journals Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Antonia Cagnetta ◽  
Davide Lovera ◽  
Raffaella Grasso ◽  
Nicoletta Colombo ◽  
Letizia Canepa ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Genomic Instability ◽  
Molecular Basis ◽  
Genome Instability ◽  
Dna Recombination ◽  
Clinical Applications ◽  
Response To Treatment ◽  
Chromosomal Segregation ◽  
Telomere Function ◽  
Mitotic Regulation

Ongoing genomic instability represents a hallmark of multiple myeloma (MM) cells, which manifests largely as whole chromosome- or translocation-based aneuploidy. Importantly, although it supports tumorigenesis, progression and, response to treatment in MM patients, it remains one of the least understood components of malignant transformation in terms of molecular basis. Therefore these aspects make the comprehension of genomic instability a pioneering strategy for novel therapeutic and clinical speculations to use in the management of MM patients. Here we will review mechanisms mediating genomic instability in MM cells with an emphasis placed on pathogenic mutations affecting DNA recombination, replication and repair, telomere function and mitotic regulation of spindle attachment, centrosome function, and chromosomal segregation. We will discuss the mechanisms by which genetic aberrations give rise to multiple pathogenic events required for myelomagenesis and conclude with a discussion of the clinical applications of these findings in MM patients.

scholarly journals Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1

2009 ◽  
Vol 187 (4) ◽  
pp. 497-511 ◽  
Author(s):  
Marco Geymonat ◽  
Adonis Spanos ◽  
Geoffroy de Bettignies ◽  
Steven G. Sedgwick
Keyword(s):  
Mutational Analysis ◽  
Spindle Pole ◽  
Cell Polarization ◽  
Nucleotide Exchange ◽  
Nucleotide Exchange Factor ◽  
Spindle Pole Bodies ◽  
Guanosine Triphosphatase ◽  
Spindle Position ◽  
Mitotic Regulation

Lte1 is a mitotic regulator long envisaged as a guanosine nucleotide exchange factor (GEF) for Tem1, the small guanosine triphosphatase governing activity of the Saccharomyces cerevisiae mitotic exit network. We demonstrate that this model requires reevaluation. No GEF activity was detectable in vitro, and mutational analysis of Lte1’s putative GEF domain indicated that Lte1 activity relies on interaction with Ras for localization at the bud cortex rather than providing nucleotide exchange. Instead, we found that Lte1 can determine the subcellular localization of Bfa1 at spindle pole bodies (SPBs). Under conditions in which Lte1 is essential, Lte1 promoted the loss of Bfa1 from the maternal SPB. Moreover, in cells with a misaligned spindle, mislocalization of Lte1 in the mother cell promoted loss of Bfa1 from one SPB and allowed bypass of the spindle position checkpoint. We observed that lte1 mutants display aberrant localization of the polarity cap, which is the organizer of the actin cytoskeleton. We propose that Lte1’s role in cell polarization underlies its contribution to mitotic regulation.

Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein

Science ◽  
1994 ◽  
Vol 265 (5170) ◽  
pp. 394-398 ◽  
Author(s):  
H Liao ◽  
G Li ◽  
T. Yen
Keyword(s):  
Cross Linking ◽  
Kinetochore Protein ◽  
Mitotic Regulation
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