scholarly journals Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons

2017 ◽  
Vol 5 ◽  
Author(s):  
Héctor Gálvez ◽  
Gina Abelló ◽  
Fernando Giraldez
Keyword(s):  
Transcription Factors ◽  
Inner Ear ◽  
Hair Cells ◽  
Ear Development ◽  
Inner Ear Development

Comparative analysis of conservation and regulatory network on core transcription factors in mouse inner ear development

2013 ◽  
Vol 35 (10) ◽  
pp. 1198-1208
Author(s):  
Zhi-Qiang CHEN ◽  
Xin-Huan HAN ◽  
Qin-Jun WEI ◽  
Guang-Qian XING ◽  
Xin CAO
Keyword(s):  
Transcription Factors ◽  
Comparative Analysis ◽  
Inner Ear ◽  
Regulatory Network ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development

2017 ◽  
Vol 423 (2) ◽  
pp. 126-137 ◽  
Author(s):  
Jeremy S. Duncan ◽  
Michelle L. Stoller ◽  
Andrew F. Francl ◽  
Fadel Tissir ◽  
Danelle Devenport ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Planar Polarity ◽  
Ear Development ◽  
Vestibular Hair Cells ◽  
Inner Ear Development

scholarly journals Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development

Development ◽  
2007 ◽  
Vol 134 (24) ◽  
pp. 4405-4415 ◽  
Author(s):  
S. Raft ◽  
E. J. Koundakjian ◽  
H. Quinones ◽  
C. S. Jayasena ◽  
L. V. Goodrich ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Sensory Hair ◽  
Ear Development ◽  
Inner Ear Development ◽  
Sensory Hair Cells

scholarly journals Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle

Development ◽  
2020 ◽  
Vol 147 (22) ◽  
pp. dev192849
Author(s):  
Evan M. Ratzan ◽  
Anne M. Moon ◽  
Michael R. Deans
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Hair Cells ◽  
Conditional Knockout ◽  
Developmental Model ◽  
Type I ◽  
Ear Development ◽  
Inner Ear Development ◽  
Morphological Criteria ◽  
Genetic Labeling

ABSTRACTFGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely to be spatially restricted and temporally dynamic throughout inner ear development. We evaluated these characteristics using genetic labeling mediated by Fgf8mcm gene-targeted mice and determined that Fgf8 expression is a specific and early marker of Type-I vestibular hair cell identity. Fgf8mcm expression initiates at E11.5 in the future striolar region of the utricle, labeling hair cells following EdU birthdating, and demonstrates that sub-type identity is determined shortly after terminal mitosis. This early fate specification is not apparent using markers or morphological criteria that are not present before birth in the mouse. Although analyses of Fgf8 conditional knockout mice did not reveal developmental phenotypes, the restricted pattern of Fgf8 expression suggests that functionally redundant FGF ligands may contribute to vestibular hair cell differentiation and supports a developmental model in which Type-I and Type-II hair cells develop in parallel rather than from an intermediate precursor.

The Effect of Tgfß-2 on Inner Ear Development: Light and Electron Microscopy Observations

1997 ◽  
Vol 3 (S2) ◽  
pp. 173-174
Author(s):  
R. Friedman ◽  
N. Paradies ◽  
S. Wert ◽  
T. Doetschman ◽  
E.L. Cardell
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Light And Electron Microscopy ◽  
Membranous Labyrinth ◽  
Ear Development ◽  
Inner Ear Development

Transforming growth factor beta (TGFß) genes are linked to a variety of developmental processes and are the subject of in vivo and in vitro transgene research studies. We are evaluating TGFß-2 effects on mouse inner ear development, with emphasis on the cochlear duct (CD), by comparing plastic sections of intact inner ears from developmental day (D) 16.5,18.5 and 19.5 littermates with wildtype (+/+), heterozygous (+/−) and mutant (−/−) TGFß-2 genotypes as determined by polymerase chain reaction analysis of tail digests. Auditory and vestibular organs of all D16.5 mice appear similar: membranous labyrinth epithelium varies from simple cuboidal/low columnar to pseudostratified/stratified columnar. Surrounding mesenchyme varies in cell density regionally, the most cellular mesenchyme underlies areas of sensory epithelium. Sparse mesenchymal cell distribution in the vestibule and basal CD indicates sites of perilymph channel formation. The spiral and vestibular ganglia and their unmyelinated fibers are prominent. Otoconia and hair cells are present in the utricle (U) and saccule (S) maculae; hair cells are less easily identifiable in the CD.

scholarly journals Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development

Biology Open ◽  
2017 ◽  
Vol 6 (9) ◽  
pp. 1270-1278 ◽  
Author(s):  
Simone Schwarzer ◽  
Sandra Spieß ◽  
Michael Brand ◽  
Stefan Hans
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Sensory Hair ◽  
Ear Development ◽  
Inner Ear Development ◽  
Sensory Hair Cells

scholarly journals Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development

2008 ◽  
Vol 237 (11) ◽  
pp. 3305-3312 ◽  
Author(s):  
Mingqian Huang ◽  
Cyrille Sage ◽  
Huawei Li ◽  
Mengquig Xiang ◽  
Stefan Heller ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Inner Ear ◽  
Expression Patterns ◽  
Ear Development ◽  
Inner Ear Development ◽  
Lim Homeodomain ◽  
Homeodomain Transcription Factors
Sign in / Sign up

Export Citation Format

Share Document