scholarly journals Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons

2016 ◽  
Vol 4 ◽  
Author(s):  
Iryna Leshchyns'ka ◽  
Vladimir Sytnyk
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Immunoglobulin Superfamily ◽  
Reciprocal Interactions

scholarly journals The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1503 ◽  
Author(s):  
Hintermann ◽  
Christen
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Hepatic Fibrosis ◽  
Cell Adhesion Molecules ◽  
Tissue Injury ◽  
Immunoglobulin Superfamily ◽  
Cell Contact ◽  
Matrix Remodeling ◽  
Direct Cell ◽  
The Many

Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The protagonists in this process, either liver-resident cells or patrolling leukocytes attracted to the site of tissue damage, interact with each other by soluble factors but also by direct cell–cell contact mediated by cell adhesion molecules. Since cell adhesion molecules also support binding to the extracellular matrix, they represent excellent biosensors, which allow cells to modulate their behavior based on changes in the surrounding microenvironment. In this review, we focus on selectins, cadherins, integrins and members of the immunoglobulin superfamily of adhesion molecules as well as some non-classical cell adhesion molecules in the context of hepatic fibrosis. We describe their liver-specific contributions to leukocyte recruitment, cell differentiation and survival, matrix remodeling or angiogenesis and touch on their suitability as targets in antifibrotic therapies.

scholarly journals The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chee Wai Wong ◽  
Danielle E. Dye ◽  
Deirdre R. Coombe
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cancer Progression ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Clinical Problem ◽  
Metastatic Lesion ◽  
Immunoglobulin Superfamily ◽  
Metastatic Pathway ◽  
Cell Cell

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes.

Measuring very low affinity interactions between immunoglobulin superfamily cell-adhesion molecules

1993 ◽  
Vol 21 (4) ◽  
pp. 340S-340S ◽  
Author(s):  
P. A. VAN DER MERWE ◽  
M. H. BROWN ◽  
S. J. DAVIS ◽  
A. N. BARCLAY
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Immunoglobulin Superfamily

scholarly journals Expression of the Immunoglobulin Superfamily Cell Adhesion Molecules in the Developing Spinal Cord and Dorsal Root Ganglion

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121550 ◽  
Author(s):  
Zirong Gu ◽  
Fumiyasu Imai ◽  
In Jung Kim ◽  
Hiroko Fujita ◽  
Kei ichi Katayama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Adhesion ◽  
Dorsal Root Ganglion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Dorsal Root ◽  
Immunoglobulin Superfamily ◽  
Developing Spinal Cord
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