scholarly journals Cancer-associated mesenchymal stem cells aggravate tumor progression

2015 ◽  
Vol 3 ◽  
Author(s):  
Chie Kudo-Saito
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Progression

Recruited Brain Tumor-Derived Mesenchymal Stem Cells Contribute to Brain Tumor Progression

Stem Cells ◽  
2014 ◽  
Vol 32 (5) ◽  
pp. 1110-1123 ◽  
Author(s):  
Jinan Behnan ◽  
Pauline Isakson ◽  
Mrinal Joel ◽  
Corrado Cilio ◽  
Iver A. Langmoen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumor ◽  
Tumor Progression

scholarly journals Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells

2013 ◽  
Vol 104 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Ayano Kabashima-Niibe ◽  
Hajime Higuchi ◽  
Hiromasa Takaishi ◽  
Yohei Masugi ◽  
Yumi Matsuzaki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Pancreatic Cancer Cells

Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression

2018 ◽  
Vol 234 (4) ◽  
pp. 3394-3409 ◽  
Author(s):  
Samaneh Shojaei ◽  
Seyed Mahmoud Hashemi ◽  
Hossein Ghanbarian ◽  
Mohammad Salehi ◽  
Samira Mohammadi-Yeganeh
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Tumor Suppression

scholarly journals Mesenchymal Stem Cells Promote Tumor Progression via Inducing Stroma Remodeling on Rabbit VX2 Bladder Tumor Model

2018 ◽  
Vol 14 (9) ◽  
pp. 1012-1021 ◽  
Author(s):  
Jun Chen ◽  
Lin Ma ◽  
Nianzhao Zhang ◽  
Yaofeng Zhu ◽  
Keqin Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Progression ◽  
Bladder Tumor ◽  
Tumor Model

scholarly journals Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Surendar Aravindhan ◽  
Sura Salman Ejam ◽  
Methaq Hadi Lafta ◽  
Alexander Markov ◽  
Alexei Valerievich Yumashev ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Progression ◽  
Tumor Cells ◽  
Tumor Tissue ◽  
Angiogenic Therapy ◽  
Final Destination ◽  
Tumour Vasculature

AbstractA crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate in modulation of the tumor microenvironment, and have been reported to be able to regulate and determine the final destination of tumor cell. Conflicting functions have been attributed to the activity of MSCs in the tumor microenvironment; they can confer a tumorigenic or anti-tumor potential to the tumor cells. Nonetheless, MSCs have been associated with a potential to modulate the tumor microenvironment in favouring the suppression of cancer cells, and promising results have been reported from the preclinical as well as clinical studies. Among the favourable behaviours of MSCs, are releasing mediators (like exosomes) and their natural migrative potential to tumor sites, allowing efficient drug delivering and, thereby, efficient targeting of migrating tumor cells. Additionally, angiogenesis of tumor tissue has been characterized as a key feature of tumors for growth and metastasis. Upon introduction of first anti-angiogenic therapy by a monoclonal antibody, attentions have been drawn toward manipulation of angiogenesis as an attractive strategy for cancer therapy. After that, a wide effort has been put on improving the approaches for cancer therapy through interfering with tumor angiogenesis. In this article, we attempted to have an overview on recent findings with respect to promising potential of MSCs in cancer therapy and had emphasis on the implementing MSCs to improve them against the suppression of angiogenesis in tumor tissue, hence, impeding the tumor progression.

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