Bisphosphonates in clinical practice

Bisphosphonates are analogues of pyrophosphate where P-C-P forms the core of molecule in place of P-O-P.They suppress resorption of bone while itself getting absorbed to hydroxyapetite of bone. These are classified into three generations according to modifications in side chain. Bisphosphonates are widely used for osteoporosis, hypercalcemia of malignancy, Paget's disease of bone etc.