scholarly journals Overconfidence and Early-life Experiences: The Impact of Managerial Traits on Corporate Financial Policies

2010 ◽  
Author(s):  
Ulrike Malmendier ◽  
Geoffrey Tate ◽  
Jonathan Yan
Keyword(s):  
Early Life ◽  
Life Experiences ◽  
Financial Policies ◽  
The Impact ◽  
Managerial Traits

scholarly journals Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cristian Carmeli ◽  
Zoltán Kutalik ◽  
Pashupati P. Mishra ◽  
Eleonora Porcu ◽  
Cyrille Delpierre ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Regulation ◽  
Cohort Studies ◽  
Early Life ◽  
Life Experiences ◽  
Socioeconomic Disadvantage ◽  
Mediating Role ◽  
The Impact ◽  
The Relationship

AbstractIndividuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.

Basic mechanisms of, and treatment targets for, stress-related disorders

2020 ◽  
pp. 829-839
Author(s):  
Bruce S. McEwen
Keyword(s):  
Early Life ◽  
Allostatic Load ◽  
Life Experiences ◽  
The Body ◽  
The Social ◽  
Wear And Tear ◽  
Short Run ◽  
Social And Physical Environment ◽  
The Impact ◽  
The Brain

The response to the social and physical environment involves two-way communication between the brain and the body and epigenetic adaptation (‘allostasis’) via mediators of the cardiovascular, immune, metabolic, neuroendocrine, and neural mechanisms. Chronic stress causes wear and tear on the brain and body (‘allostatic load and overload’), reflecting also the impact of health-damaging behaviours and lasting effects of early life experiences interacting with genetic predispositions. Hormonal and other mediators of allostasis promote adaptation in the short run but cause allostatic load/overload when they are overused or dysregulated. The brain is key because it determines what is threatening and the physiological and behavioural responses, while showing structural remodelling that affects its function. Besides pharmaceuticals, there are ‘top–down’ interventions, like physical activity, that engage ‘the wisdom of the body’ to change itself, as well as the impact of policies of government and business that encourage individuals to manage their own lives and promote increased ‘healthspan’.

Inflammatory and Epigenetic Pathways for Perinatal Depression

2015 ◽  
Vol 18 (3) ◽  
pp. 331-343 ◽  
Author(s):  
Lindsey Garfield ◽  
Herbert L. Mathews ◽  
Linda Witek Janusek
Keyword(s):  
Early Life ◽  
Infant Health ◽  
Perinatal Depression ◽  
Life Experiences ◽  
Perinatal Period ◽  
Early Life Adversity ◽  
Targeted Interventions ◽  
Increased Risk ◽  
History Of ◽  
The Impact

Depression during the perinatal period is common and can have adverse consequences for women and their children. Yet, the biobehavioral mechanisms underlying perinatal depression are not known. Adverse early life experiences increase the risk for adult depression. One potential mechanism by which this increased risk occurs is epigenetic embedding of inflammatory pathways. The purpose of this article is to propose a conceptual model that explicates the linkage between early life adversity and the risk for maternal depression. The model posits that early life adversity embeds a proinflammatory epigenetic signature (altered DNA methylation) that predisposes vulnerable women to depression during pregnancy and the postpartum period. As proposed, women with a history of early life adversity are more likely to exhibit higher levels of proinflammatory cytokines and lower levels of oxytocin in response to the demands of pregnancy and new motherhood, both of which are associated with the risk for perinatal depression. The model is designed to guide investigations into the biobehavioral basis for perinatal depression, with emphasis upon the impact of early life adversity. Testing this model will provide a better understanding of maternal depressive risk and improve identification of vulnerable women who would benefit from targeted interventions that can reduce the impact of perinatal depression on maternal–infant health.

scholarly journals How Do Memories of Having Been Parented Relate to the Parenting-Experience of Fathers in Treatment for Intimate Partner Violence? A Phenomenological Analysis

2020 ◽  
Author(s):  
Henning Mohaupt ◽  
Fanny Duckert ◽  
Ingunn Rangul Askeland
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Early Life ◽  
Meaning Making ◽  
Life Experiences ◽  
Intimate Partner ◽  
Phenomenological Analysis ◽  
Childhood Experiences ◽  
Child Relationship ◽  
The Impact

Abstract Few studies have examined how men who use intimate partner violence (IPV) experience being a parent. This study describes how Norwegian men in treatment for IPV reflect upon the impact of their childhood experiences on their fathering. We interviewed 11 men in treatment for IPV regarding their fathering experience, and their memories of having been parented. We performed a descriptive phenomenological analysis of the data. We identified two superordinate themes that described the participants’ fathering experience: being a benign versus being a detrimental force in the child’s life and having the intention of not repeating and the actual repetition of harmful parenting. The participants described being conflicted regarding being potentially damaging for their child’s development. They generally described a lack of stable positive relationships, both early in life and in the present. Partner-violent men’s meaning making of their fathering seems to be influenced by their early-life experiences with their parents in several problematic ways. Fathers who use IPV may both accept and reject that they have been harmed by the parenting they received as children. Similarly, they may both acknowledge and discard that their use of violence harms their children. We suggest that therapy should explore these themes and their consequences for the father - child relationship.

Haunted by Pain, Fatigue, and Insomnia

2021 ◽  
pp. 17-26
Author(s):  
Daniel M. Doleys ◽  
Nicholas D. Doleys
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Chronic Pain ◽  
Posttraumatic Stress ◽  
Early Life ◽  
Stress Disorder ◽  
Life Experiences ◽  
Well Being ◽  
Physical Consequences ◽  
Pain Recognition ◽  
The Impact

The impact of an accident or injury, even if the physical consequences seem relatively minor in nature, can have a prolonged effect on an individual’s psychological well-being. Emotionally traumatic, early-life experiences, have been linked to certain chronic pain problems. Some patients are embarrassed by the effect and feel they should be mentally strong enough to overcome it. Others submit to it and become immobilized. It can significantly magnify the experience of pain. Recognition and treatment of posttraumatic stress disorder need not be overly complicated. Some cases may require referral to a specialist. Nightmares, flash backs, hypervigilance, and avoidance are common.

scholarly journals Early Origins of Body Mass in Later Life: Examining Childhood Risks and Adult Pathways

2021 ◽  
pp. 002214652110054
Author(s):  
Sarah A. Mustillo ◽  
Miao Li ◽  
Patricia Morton ◽  
Kenneth F. Ferraro
Keyword(s):  
Physical Activity ◽  
Body Mass ◽  
Health Risks ◽  
Early Life ◽  
Life Experiences ◽  
Later Life ◽  
Childhood Experiences ◽  
Older Adulthood ◽  
Early Life Exposure ◽  
Nationally Representative

Prior research reveals that negative early-life experiences play a major role in the development of obesity in later life, but few studies identify mechanisms that alter the lifetime risk of obesity. This study examines the influence of negative childhood experiences on body mass index (BMI) and obesity (BMI ≥30) during older adulthood and the psychosocial and behavioral pathways involved. Using a nationally representative sample, we examine the influence of cumulative misfortune as well as five separate domains of misfortune on BMI and obesity. Results show that four of the five domains are associated with BMI and obesity either directly, indirectly, or both. The influence of cumulative misfortune on the outcomes is mediated by three adult factors: socioeconomic status, depressive symptoms, and physical activity. The mediators identified here provide targets for intervention among older adults to help offset the health risks of excess BMI attributable of early-life exposure to misfortune.

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