scholarly journals Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells

2019 ◽  
Vol 98 (12) ◽  
pp. 6367-6377 ◽  
Author(s):  
Huijie Chen ◽  
Rui Feng ◽  
Ishfaq Muhammad ◽  
Ghulam Abbas ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Infectious Bronchitis Virus ◽  
Chicken Embryo ◽  
Reactive Oxygen ◽  
Kidney Cells ◽  
Oxygen Species ◽  
Protective Effects ◽  
Infectious Bronchitis ◽  
Induced Apoptosis

Protective effects of Brazilian native fruits against reactive oxygen species

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
J Infante ◽  
A Massarioli ◽  
PL Rosalen ◽  
S Alencar
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Protective Effects

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints

2016 ◽  
Vol 87 ◽  
pp. 65-76 ◽  
Author(s):  
João G. Costa ◽  
Nuno Saraiva ◽  
Patrícia S. Guerreiro ◽  
Henriqueta Louro ◽  
Maria J. Silva ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ochratoxin A ◽  
Reactive Oxygen ◽  
Integrative Approach ◽  
Kidney Cells ◽  
Oxygen Species

Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages

2001 ◽  
Vol 280 (1) ◽  
pp. L10-L17 ◽  
Author(s):  
Han-Ming Shen ◽  
Zhuo Zhang ◽  
Qi-Feng Zhang ◽  
Choon-Nam Ong
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Alveolar Macrophages ◽  
Caspase 3 ◽  
Reactive Oxygen ◽  
Parp Cleavage ◽  
Oxygen Species ◽  
Caspase Activation ◽  
Caspase 9 ◽  
Induced Apoptosis

Alveolar macrophages (AMs) are the principal target cells of silica and occupy a key position in the pathogenesis of silica-related diseases. Silica has been found to induce apoptosis in AMs, whereas its underlying mechanisms involving the initiation and execution of apoptosis are largely unknown. The main objective of the present study was to examine the form of cell death caused by silica and the mechanisms involved. Silica-induced apoptosis in AMs was evaluated by terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling assay and cell cycle/DNA content analysis. The elevated level of reactive oxygen species (ROS), caspase-9 and caspase-3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage in silica-treated AMs were also determined. The results showed that there was a temporal pattern of apoptotic events in silica-treated AMs, starting with ROS formation and followed by caspase-9 and caspase-3 activation, PARP cleavage, and DNA fragmentation. Silica-induced apoptosis was significantly attenuated by a caspase-3 inhibitor, N-acetyl-Asp-Glu-Val-Asp aldehyde, and ebselen, a potent antioxidant. These findings suggest that apoptosis is an important form of cell death caused by silica exposure in which the elevated ROS level that results from silica exposure may act as an initiator, leading to caspase activation and PARP cleavage to execute the apoptotic process.

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