scholarly journals The Salmonella Enteritidis TolC outer membrane channel is essential for egg white survival

2019 ◽  
Vol 98 (5) ◽  
pp. 2281-2289 ◽  
Author(s):  
R. Raspoet ◽  
V. Eeckhaut ◽  
K. Vermeulen ◽  
L. De Smet ◽  
Y. Wen ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Salmonella Enteritidis ◽  
Egg White ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e97475 ◽  
Author(s):  
Hsiang-Ting Lei ◽  
Tsung-Han Chou ◽  
Chih-Chia Su ◽  
Jani Reddy Bolla ◽  
Nitin Kumar ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Neisseria Gonorrhoeae ◽  
Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals An Excretory Function for the Escherichia coli Outer Membrane Pore TolC: Upregulation of marA and soxS Transcription and Rob Activity Due to Metabolites Accumulated in tolC Mutants

2009 ◽  
Vol 191 (16) ◽  
pp. 5283-5292 ◽  
Author(s):  
Judah L. Rosner ◽  
Robert G. Martin
Keyword(s):  
Escherichia Coli ◽  
Outer Membrane ◽  
Bile Salts ◽  
Efflux Pumps ◽  
Membrane Channel ◽  
Protein Activity ◽  
Membrane Pore ◽  
Excretory Function ◽  
Outer Membrane Channel ◽  
Transcriptional Fusions

ABSTRACT Efflux pumps function to rid bacteria of xenobiotics, including antibiotics, bile salts, and organic solvents. TolC, which forms an outer membrane channel, is an essential component of several efflux pumps in Escherichia coli. We asked whether TolC has a role during growth in the absence of xenobiotics. Because tolC transcription is activated by three paralogous activators, MarA, SoxS, and Rob, we examined the regulation of these activators in tolC mutants. Using transcriptional fusions, we detected significant upregulation of marRAB and soxS transcription and Rob protein activity in tolC mutants. Three mechanisms could be distinguished: (i) activation of marRAB transcription was independent of marRAB, soxR, and rob functions; (ii) activation of soxS transcription required SoxR, a sensor of oxidants; and (iii) Rob protein was activated posttranscriptionally. This mechanism is similar to the mechanisms of upregulation of marRAB, soxS, and Rob by treatment with certain phenolics, superoxides, and bile salts, respectively. The transcription of other marA/soxS/rob regulon promoters, including tolC itself, was also elevated in tolC mutants. We propose that TolC is involved in the efflux of certain cellular metabolites, not only xenobiotics. As these metabolites accumulate during growth, they trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites, thereby restoring homeostasis.

scholarly journals Peptide translocation across MOMP, the major outer membrane channel from Campylobacter jejuni

2017 ◽  
Vol 11 ◽  
pp. 79-83 ◽  
Author(s):  
Naresh Niranjan Dhanasekar ◽  
Soumeya Aliouane ◽  
Mathias Winterhalter ◽  
Jean-Marie Pagès ◽  
Jean-Michel Bolla
Keyword(s):  
Outer Membrane ◽  
Campylobacter Jejuni ◽  
Membrane Channel ◽  
Outer Membrane Channel ◽  
Peptide Translocation

scholarly journals Quantification of Fluoroquinolone Uptake through the Outer Membrane Channel OmpF ofEscherichia coli

2015 ◽  
Vol 137 (43) ◽  
pp. 13836-13843 ◽  
Author(s):  
Jehangir Cama ◽  
Harsha Bajaj ◽  
Stefano Pagliara ◽  
Theresa Maier ◽  
Yvonne Braun ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Ofescherichia Coli ◽  
Membrane Channel ◽  
Outer Membrane Channel
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