scholarly journals Ingestion of paddy rice increases intestinal mucin secretion and goblet cell number and prevents dextran sodium sulfate-induced intestinal barrier defect in chickens

2018 ◽  
Vol 97 (10) ◽  
pp. 3577-3586 ◽  
Author(s):  
A Murai ◽  
K Kitahara ◽  
H Terada ◽  
A Ueno ◽  
Y Ohmori ◽  
...  
Keyword(s):  
Goblet Cell ◽  
Sodium Sulfate ◽  
Intestinal Barrier ◽  
Cell Number ◽  
Paddy Rice ◽  
Dextran Sodium Sulfate ◽  
Mucin Secretion ◽  
Intestinal Mucin ◽  
Barrier Defect

scholarly journals Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice

2021 ◽  
Vol 14 (8) ◽  
pp. 822
Author(s):  
Shijia Pan ◽  
Fan Hong ◽  
Letong Li ◽  
Yuan Guo ◽  
Xiaoxiao Qiao ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Antioxidant Activities ◽  
Intestinal Barrier ◽  
Inflammatory Cells ◽  
Inhibitory Effect ◽  
Immune Defense ◽  
Dextran Sodium Sulfate ◽  
Obese Mice ◽  
Promoting Effect ◽  
Anti Inflammatory

Epidemiological studies have indicated that obesity is an independent risk factor for colitis and that a high-fat diet (HFD) increases the deterioration of colitis-related indicators in mice. Melatonin has multiple anti-inflammatory effects, including inhibiting tumor growth and regulating immune defense. However, the mechanism of its activity in ameliorating obesity-promoted colitis is still unclear. This study explored the possibility that melatonin has beneficial functions in HFD-induced dextran sodium sulfate (DSS)-induced colitis in mice. Here, we revealed that HFD-promoted obesity accelerated DSS-induced colitis, while melatonin intervention improved colitis. Melatonin significantly alleviated inflammation by increasing anti-inflammatory cytokine release and reducing the levels of proinflammatory cytokines in HFD- and DSS-treated mice. Furthermore, melatonin expressed antioxidant activities and reversed intestinal barrier integrity, resulting in improved colitis in DSS-treated obese mice. We also found that melatonin could reduce the ability of inflammatory cells to utilize fatty acids and decrease the growth-promoting effect of lipids by inhibiting autophagy. Taken together, our study indicates that the inhibitory effect of melatonin on autophagy weakens the lipid-mediated prosurvival advantage, which suggests that melatonin-targeted autophagy may provide an opportunity to prevent colitis in obese individuals.

scholarly journals Low-Methoxyl Pectin Stimulates Small Intestinal Mucin Secretion Irrespective of Goblet Cell Proliferation and Is Characterized by Jejunum Muc2 Upregulation in Rats

2012 ◽  
Vol 143 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Shingo Hino ◽  
Kei Sonoyama ◽  
Hiroyuki Bito ◽  
Hirokazu Kawagishi ◽  
Seiichiro Aoe ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Goblet Cell ◽  
Mucin Secretion ◽  
Intestinal Mucin ◽  
Small Intestinal

scholarly journals Ginseng Polysaccharides and its Effective Subfraction Protects Against Dextran Sodium Sulfate-Induced Colitis via Regulating NF-κB Signaling Pathway, Recovering Intestinal Barrier and Adjusting Gut Microbiota

2021 ◽  
Author(s):  
Shanshan Li ◽  
Yuli Qi ◽  
Duoduo Ren ◽  
Yue Zhang ◽  
Yinshi Sun
Keyword(s):  
Gut Microbiota ◽  
Signaling Pathway ◽  
Sodium Sulfate ◽  
Intervention Strategy ◽  
Intestinal Barrier ◽  
Dextran Sodium Sulfate ◽  
Signalling Pathway ◽  
Ginseng Polysaccharide ◽  
Acidic Fraction ◽  
Related Proteins

Abstract Background: Polysaccharides from Panax ginseng is a natural carbohydrates with multiple activities. Our previous work found that ginseng polysaccharide could recover the gut microbiota dysbiosis caused by antibiotic. However, it was little known about its functions on colitis. In this study, we aim to investigate the protective effects of ginseng polysaccharide (WGP), its neutral fraction (WGPN) and acidic fraction (WGPA) on dextran sodium sulfate (DSS) induced colitis and the potential mechanisms with pharmacological experiments.Methods: Animal model of DSS-induced colitis was constructed by male Wistar rats. Disease activity index (DAI) scores, weight increment, colon weights, and colon length were recorded. Physiological and histological parameters, tight junctions proteins, inflammatory factors, gut microbiota, short-chain fatty acids (SCFAs) and NF-kB signalling pathway related proteins were compared among the five experimental groups, which were treated with a normal diet (Con group), DSS (DSS group), WGP (WGP group), WGPN (WGPN group), and WGPA (WGPA group), respectively. Results: Both WGP and WGPA alleviated the colitis symptoms and colon structure changes of colitis rats. They can decreased the DAIs and improved colon health; reduced colon damage and recovered intestinal barrier via regulating the tight-junction related proteins (ZO-1 and Occludin); downregulated inflammatory cytokines (IL-1β, IL-2, IL-6, and IL-17) and inhibited the TLR4/MyD88/NF-kB signalling pathway in the colon; regulated the diversity and composition of gut microbiota, especially the relative abundance of Ruminococcus; enhanced the production of SCFAs. Conclusions: WGP exerted had a protective effect against colitis through regulating NF-kB signaling pathway, recovering intestinal barrier and adjusting gut microbiota, with its acidic fraction (WGPA) primarily contributing to this activity. The results support to the utilization and investigation of ginseng polysaccharides as potential intervention strategy for the prevention of colitis.

Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, reducing oxidative stress and inflammatory responses

2021 ◽  
Author(s):  
Yu-Jing Wang ◽  
Qiang-Ming Li ◽  
Xueqiang Zha ◽  
Jian-Ping Luo
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Inflammatory Responses ◽  
Intestinal Barrier ◽  
Dextran Sodium Sulfate ◽  
Intestinal Barrier Function ◽  
Study Results ◽  
Ameliorative Effect ◽  
Dendrobium Fimbriatum

The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study. Results showed that cDFPW1 effectively improved colitis...

scholarly journals Acer palmatum thumb. Ethanol Extract Alleviates Interleukin-6-Induced Barrier Dysfunction and Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Kwang-Youn Kim ◽  
Tae-Woo Oh ◽  
Hyun Ju Do ◽  
Ju-Hye Yang ◽  
In Jun Yang ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Barrier Function ◽  
Sodium Sulfate ◽  
Intestinal Barrier ◽  
Ethanol Extract ◽  
Dextran Sodium Sulfate ◽  
Intestinal Barrier Function ◽  
Control Group ◽  
Barrier Dysfunction ◽  
Acute Colitis

Ulcerative colitis is one inflammatory bowel disease (IBD) and is caused by diverse factors, including the extent and duration of intestinal inflammation. We investigated the effect of Acer palmatum thumb. ethanol extract (KIOM-2015E) on the expression of tight junction proteins and the levels of inflammation in the cell model induced with interleukin-6- (IL-6-) and mouse model of dextran sodium sulfate (DSS) induced with acute colitis. KIOM-2015E (100 mg/kg) was orally administered once per day to BALB/C mice with colitis induced by administration of 5% DSS in drinking water. KIOM-2015E did not affect viability in Caco-2 cells. Also, KIOM-2015E repaired the IL-6-induced intestinal barrier dysfunction in Caco-2 cells. Furthermore, KIOM-2015E recovered the loss of body weight and the abnormally short colon lengths in the DSS-induced model of acute colitis. Moreover, KIOM-2015E significantly inhibited the decrease of zonula occluden-1 and occludin in colonic tissue relative to the DSS-treated control group. KIOM-2015E also significantly inhibited the expression of IL-6 and tumor necrosis factor-α in the level of serum relative to the control group. Collectively, these data suggest that KIOM-2015E protects colitis principally by improving intestinal barrier function and promoting anti-inflammatory responses. In turn, these effects inhibit macrophage infiltration into the colon and thus may be a candidate treatment for IBD.

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