scholarly journals Effects of heat shock protein 90 expression on pectoralis major oxidation in broilers exposed to acute heat stress

2014 ◽  
Vol 93 (11) ◽  
pp. 2709-2717 ◽  
Author(s):  
Y. Hao ◽  
X.H. Gu
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Pectoralis Major ◽  
Acute Heat Stress ◽  
Major Oxidation

Heat shock protein 90 does not contribute to cutaneous vasodilatation in older adults during heat stress

2019 ◽  
Vol 26 (6) ◽  
Author(s):  
Naoto Fujii ◽  
Gregory W. McGarr ◽  
Kion Hatam ◽  
Nithila Chandran ◽  
Caroline M. Muia ◽  
...  
Keyword(s):  
Older Adults ◽  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Cutaneous Vasodilatation

Effect of acute heat stress on heat shock protein 70 messenger RNA and on heat shock protein expression in the liver of broilers

1996 ◽  
Vol 37 (2) ◽  
pp. 443-449 ◽  
Author(s):  
J. E. Gabriel ◽  
J. A. Ferro ◽  
R. M. P. Stefani ◽  
M. I. T. Ferro ◽  
S. L. Gomes ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Expression ◽  
Heat Shock Protein 70 ◽  
Messenger Rna ◽  
Acute Heat Stress ◽  
Heat Shock Protein Expression

Heat shock protein 27 response to acute heat stress in the porcine semitendinosus

Meat Science ◽  
2016 ◽  
Vol 112 ◽  
pp. 171-172
Author(s):  
K.B. Carlson ◽  
S.C. Pearce ◽  
L.H. Baumgard ◽  
N.K. Gabler ◽  
S.M. Lonergan ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Acute Heat Stress

scholarly journals Thermosensitization of tumor cells with inhibitors of chaperone activity and expression

2012 ◽  
Vol 58 (6) ◽  
pp. 662-672 ◽  
Author(s):  
V.A. Kudryavtsev ◽  
Y.M. Makarova ◽  
A.E. Kabakov
Keyword(s):  
Cell Death ◽  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
De Novo ◽  
Heat Shock Protein 90 ◽  
Chaperone Activity ◽  
Hsp90 Activity ◽  
Hsp90 Chaperone

Effects of inhibitors of the heat shock protein 90 (HSP90) chaperone activity and inhibitors of the heat shock protein (HSP) expression on sensitivity of HeLa tumor cells to hyperthermia were studied. It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43°C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels. If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating. Importantly, in the case of conjunction of all the three treatments (an inhibitor of the HSP90 activity + an inhibitor of the HSP induction + 43°C for 60 min), the reporter reactivation was retarded yet stronger while the cell death was sharply (2-3-fold) enhanced. Such an enhancement of the cytotoxicity appears to occur owing to the "chaperone deficiency" when prior to heat stress both the functional activity of constitutive HSP90 and the expression of additional (inducible) chaperones are blocked in the cells.

Sign in / Sign up

Export Citation Format

Share Document