scholarly journals Performance, serum biochemical responses, and gene expression of intestinal folate transporters of young and older laying hens in response to dietary folic acid supplementation and challenge with Escherichia coli lipopolysaccharide

2014 ◽  
Vol 93 (1) ◽  
pp. 122-131 ◽  
Author(s):  
M. Jing ◽  
P.M. Munyaka ◽  
G.B. Tactacan ◽  
J.C. Rodriguez-Lecompte ◽  
K. O ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Folic Acid ◽  
Laying Hens ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Biochemical Responses ◽  
Serum Biochemical ◽  
Folate Transporters ◽  
Escherichia Coli Lipopolysaccharide

Folic acid supplementation dysregulates gene expression in lymphoblastoid cells – Implications in nutrition

2011 ◽  
Vol 412 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Mohammed A. Junaid ◽  
Salomon Kuizon ◽  
Juan Cardona ◽  
Tayaba Azher ◽  
Noriko Murakami ◽  
...  
Keyword(s):  
Gene Expression ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Lymphoblastoid Cells ◽  
Acid Supplementation

scholarly journals Folate Supplementation during Oocyte Maturation Positively Impacts the Folate-Methionine Metabolism in Pre-Implantation Embryos

2021 ◽  
Author(s):  
Sikander Saini ◽  
Vishal Sharma ◽  
Shama Ansari ◽  
Amit Kumar ◽  
Abhishek Thakur ◽  
...  
Keyword(s):  
Folic Acid ◽  
Production Rate ◽  
Oocyte Maturation ◽  
Folic Acid Supplementation ◽  
Folate Metabolism ◽  
Acid Supplementation ◽  
Maturation Medium ◽  
Metabolism Enzymes ◽  
Methionine Cycle ◽  
Folate Transporters

Abstract Folic acid is vital for DNA synthesis and methylations through one-carbon (C1) metabolism. Thus, it is essential for cell division during embryonic development. The present study investigated the effect of folic acid supplementation on oocyte maturation, blastocyst development and the expression of folate transporters as well as folate metabolism enzymes in oocytes and pre-implantation embryos of goat. Immature goat oocytes, matured in maturation medium comprising different folic acid concentrations (0, 10, 50, 100 and 150 µM), were in vitro fertilized and cultured. Cumulus expansion markers (Ptx3 and Ptgs2) in cumulus cells were highly upregulated after 50 µM folic acid supplementation indicating higher degree of maturation. Supplementation of 50 µM folic acid during oocyte maturation resulted in significantly higher blastocyst production rate, reduction in intracellular ROS levels as well as upregulation of the transcripts for folate transporters and key folate-methionine cycle enzymes in comparison to control. The present study demonstrates the existence of active folate-methionine cycle in oocytes and pre-implantation goat embryos. Supplementation of 50 µM folic acid in maturation medium increases the blastocyst production rate, improves oocyte maturation, reduces ROS production as well as upregulate the expression of Folr1 and folate metabolism enzyme, Mtr.

scholarly journals Folic acid supplementation for 12 weeks modifies gene expression in leukocytes in men with low folate status

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Ligi Paul ◽  
Cristina Razzari ◽  
Francesca Sampietro ◽  
Gessica Fontana ◽  
Isabella Fermo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Folate Status

The effect of folic acid supplementation during the juvenile pubertal period or adulthood on gene expression in the ovary

2016 ◽  
Author(s):  
Reyna Penailillo Escarate ◽  
Mark Burton ◽  
Graham Burdge ◽  
Judith Eckert ◽  
Tom Fleming ◽  
...  
Keyword(s):  
Gene Expression ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

scholarly journals Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring in a sex-specific manner

2016 ◽  
Vol 41 (4) ◽  
pp. 411-420 ◽  
Author(s):  
Pedro S.P. Huot ◽  
Anna Ly ◽  
Ignatius M.Y. Szeto ◽  
Sandra A. Reza-López ◽  
Daniel Cho ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Body Weight ◽  
Folic Acid ◽  
Acid Content ◽  
Maternal Diet ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Rat Offspring ◽  
Specific Manner

Maternal intake of multivitamins or folic acid above the basal dietary requirement alters the growth and metabolic trajectory of rat offspring. We hypothesized that a modest increase in the folic acid content of maternal diets would alter the offspring’s metabolic phenotype, and that these effects could be corrected by matching the folic acid content of the offspring’s diet with that of the maternal diet. Female Sprague–Dawley rats were placed on a control or a 2.5× folic acid-supplemented diet prior to mating and during pregnancy and lactation. At weaning, pups from each maternal diet group were randomized to the control or to the 2.5× folic acid-supplemented diet for 25 weeks. Male pups from dams fed the folic acid-supplemented diet were 3.7% heavier than those from control-fed dams and had lower mRNA expression for leptin receptor Obrb isoform (Lepr) (11%) and Agouti-related protein (Agrp) (14%). In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression. Folic acid supplementation ameliorated the alterations induced by maternal folic acid supplementation in male pups and led to the lowest insulin resistance, but the effects were smaller in female pups and led to the highest insulin resistance. In conclusion, maternal folic acid supplementation at 2.5× the control level was associated with alterations in body weight and hypothalamic gene expression in rat offspring in a sex-specific manner, and some of these effects were attenuated by postweaning folic acid supplementation.

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