scholarly journals Temporary modulation of responses to common vaccines and serum cation status in broilers during exposure to low doses of aflatoxin B1

2013 ◽  
Vol 92 (11) ◽  
pp. 2899-2903 ◽  
Author(s):  
A.W. Yunus ◽  
J. Böhm
Keyword(s):  
Aflatoxin B1 ◽  
Low Doses ◽  
Cation Status

Fractionation Of Radioactivity In The Milk Of Goats Administered 14c-Aflatoxin B1

1985 ◽  
Vol 68 (3) ◽  
pp. 456-458
Author(s):  
Tetsuhisa Goto ◽  
Dennis P H Hsieh
Keyword(s):  
Aflatoxin B1 ◽  
Goat Milk ◽  
Major Metabolite ◽  
Aflatoxin M1 ◽  
Low Doses ◽  
Minor Significance ◽  
Aflatoxin B

Abstract A detailed fractionation of radioactivity in the milk of goats administered 14C-aflatoxin Bx at low doses was performed. The milk collected in the first 24 h following dosing contained radioactivity equivalent to 0.45-1.1% of the dose given. The radioactivity in each sample was partitioned into 4 fractions: ether, protein, dichloromethane, and wateralcohol. Over 80% of the radioactivity was detected in the dichloromethane fraction, of which over 95% was attributable to aflatoxin M1. No aflatoxin B, or other known aflatoxin metabolites were detected in any fraction. The results indicate that the major metabolite of aflatoxin B, in goat milk is aflatoxin M] and that other metabolites, including conjugates, are of minor significance.

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

Low doses of pamidronate to treat osteopenia in children with severe cerebral palsy: a pilot study

2006 ◽  
Vol 48 (09) ◽  
pp. 709 ◽  
Author(s):  
Horacio Plotkin ◽  
Susan Coughlin ◽  
Rose Kreikemeier ◽  
Kathryn Heldt ◽  
Matias Bruzoni ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Pilot Study ◽  
Low Doses
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