scholarly journals Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers

2012 ◽  
Vol 91 (12) ◽  
pp. 3019-3024 ◽  
Author(s):  
Y. Wang ◽  
V. Brahmakshatriya ◽  
B. Lupiani ◽  
S. Reddy ◽  
R. Okimoto ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Antiviral Responses

Induction of Antiviral Responses Against Avian Influenza Virus in Embryonated Chicken Eggs with Toll-Like Receptor Ligands

2015 ◽  
Vol 28 (4) ◽  
pp. 192-200 ◽  
Author(s):  
Neda Barjesteh ◽  
Jennifer T. Brisbin ◽  
Shahriar Behboudi ◽  
Éva Nagy ◽  
Shayan Sharif
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Antiviral Responses ◽  
Chicken Eggs ◽  
Embryonated Chicken

scholarly journals Distinct miRNA Profile of Cellular and Extracellular Vesicles Released from Chicken Tracheal Cells Following Avian Influenza Virus Infection

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 438
Author(s):  
Kelsey O’Dowd ◽  
Mehdi Emam ◽  
Mohamed Reda El Khili ◽  
Amin Emad ◽  
Eveline M. Ibeagha-Awemu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Extracellular Vesicles ◽  
Viral Infections ◽  
Influenza Virus Infection ◽  
Influenza Viruses ◽  
Host Cells ◽  
Control Group ◽  
Antiviral Responses

Innate responses provide the first line of defense against viral infections, including the influenza virus at mucosal surfaces. Communication and interaction between different host cells at the early stage of viral infections determine the quality and magnitude of immune responses against the invading virus. The release of membrane-encapsulated extracellular vesicles (EVs), from host cells, is defined as a refined system of cell-to-cell communication. EVs contain a diverse array of biomolecules, including microRNAs (miRNAs). We hypothesized that the activation of the tracheal cells with different stimuli impacts the cellular and EV miRNA profiles. Chicken tracheal rings were stimulated with polyI:C and LPS from Escherichia coli 026:B6 or infected with low pathogenic avian influenza virus H4N6. Subsequently, miRNAs were isolated from chicken tracheal cells or from EVs released from chicken tracheal cells. Differentially expressed (DE) miRNAs were identified in treated groups when compared to the control group. Our results demonstrated that there were 67 up-regulated miRNAs, 157 down-regulated miRNAs across all cellular and EV samples. In the next step, several genes or pathways targeted by DE miRNAs were predicted. Overall, this study presented a global miRNA expression profile in chicken tracheas in response to avian influenza viruses (AIV) and toll-like receptor (TLR) ligands. The results presented predicted the possible roles of some DE miRNAs in the induction of antiviral responses. The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV.

Interactions between lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus

2019 ◽  
Vol 125 ◽  
pp. 441-450 ◽  
Author(s):  
Bahram Shojadoost ◽  
Raveendra R. Kulkarni ◽  
Jennifer T. Brisbin ◽  
Wanderley Quinteiro-Filho ◽  
Tamiru N. Alkie ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Antiviral Responses

scholarly journals Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus

Membranes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 53
Author(s):  
Kelsey O’Dowd ◽  
Laura Sánchez ◽  
Jennifer Ben Salem ◽  
Francis Beaudry ◽  
Neda Barjesteh
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Extracellular Vesicles ◽  
Respiratory Infections ◽  
Protein Profile ◽  
Antiviral Responses ◽  
Viral Respiratory Infections ◽  
The Impact ◽  
Viral Respiratory

During viral respiratory infections, the innate antiviral response engages a complex network of cells and coordinates the secretion of key antiviral factors, such as cytokines, which requires high levels of regulation and communication. Extracellular vesicles (EVs) are particles released from cells that contain an array of biomolecules, including lipids, proteins, and RNAs. The contents of EVs can be influenced by viral infections and may play a role in the regulation of antiviral responses. We hypothesized that the contents of EVs released from chicken tracheal cells are influenced by viral infection and that these EVs regulate the function of other immune cells, such as macrophages. To this end, we characterized the protein profile of EVs during avian influenza virus (AIV) infection and evaluated the impact of EV stimulation on chicken macrophage functions. A total of 140 differentially expressed proteins were identified upon stimulation with various stimuli. These proteins were shown to be involved in immune responses and cell signaling pathways. In addition, we demonstrated that EVs can activate macrophages. These results suggest that EVs play a role in the induction and modulation of antiviral responses during viral respiratory infections in chickens.

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