scholarly journals Gene expression analysis of host spleen responses to Marek's disease virus infection at late tumor transformation phase

2012 ◽  
Vol 91 (9) ◽  
pp. 2130-2138 ◽  
Author(s):  
L. Lian ◽  
L.J. Qu ◽  
H.Y. Sun ◽  
Y.M. Chen ◽  
S.J. Lamont ◽  
...  
Keyword(s):  
Gene Expression ◽  
Virus Infection ◽  
Disease Virus ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Tumor Transformation

scholarly journals Marek’s Disease Virus Infection Induced Mitochondria Changes in Chickens

2019 ◽  
Vol 20 (13) ◽  
pp. 3150 ◽  
Author(s):  
Qin Chu ◽  
Yi Ding ◽  
Wentao Cai ◽  
Lei Liu ◽  
Huanmin Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mitochondrial Dna ◽  
Virus Infection ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Resistant Line ◽  
Susceptible Line

Mitochondria are crucial cellular organelles in eukaryotes and participate in many cell processes including immune response, growth development, and tumorigenesis. Marek’s disease (MD), caused by an avian alpha-herpesvirus Marek’s disease virus (MDV), is characterized with lymphomas and immunosuppression. In this research, we hypothesize that mitochondria may play roles in response to MDV infection. To test it, mitochondrial DNA (mtDNA) abundance and gene expression in immune organs were examined in two well-defined and highly inbred lines of chickens, the MD-susceptible line 72 and the MD-resistant line 63. We found that mitochondrial DNA contents decreased significantly at the transformation phase in spleen of the MD-susceptible line 72 birds in contrast to the MD-resistant line 63. The mtDNA-genes and the nucleus-genes relevant to mtDNA maintenance and transcription, however, were significantly up-regulated. Interestingly, we found that POLG2 might play a potential role that led to the imbalance of mtDNA copy number and gene expression alteration. MDV infection induced imbalance of mitochondrial contents and gene expression, demonstrating the indispensability of mitochondria in virus-induced cell transformation and subsequent lymphoma formation, such as MD development in chicken. This is the first report on relationship between virus infection and mitochondria in chicken, which provides important insights into the understanding on pathogenesis and tumorigenesis due to viral infection.

scholarly journals Gut microbiota is associated with protection against Marek's disease virus infection in chickens

Virology ◽  
2021 ◽  
Vol 553 ◽  
pp. 122-130
Author(s):  
Jegarubee Bavananthasivam ◽  
Jake Astill ◽  
Ayumi Matsuyama-Kato ◽  
Khaled Taha-Abdelaziz ◽  
Bahram Shojadoost ◽  
...  
Keyword(s):  
Virus Infection ◽  
Gut Microbiota ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

Establishment of an Aerosol-Based Marek's Disease Virus Infection Model

2009 ◽  
Vol 53 (3) ◽  
pp. 387-391 ◽  
Author(s):  
Mohamed Faizal Abdul-Careem ◽  
Abbas Javaheri-Vayeghan ◽  
Sangitha Shanmuganathan ◽  
Hamid Reza Haghighi ◽  
Leah R. Read ◽  
...  
Keyword(s):  
Virus Infection ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Infection Model ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Virus Infection Model

scholarly journals Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 557 ◽  
Author(s):  
Apratim Mitra ◽  
Juan Luo ◽  
Huanming Zhang ◽  
Kairong Cui ◽  
Keji Zhao ◽  
...  
Keyword(s):  
Virus Infection ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease
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