scholarly journals Quantitative analyses of genes associated with mucin synthesis of broiler chickens with induced necrotic enteritis

2012 ◽  
Vol 91 (6) ◽  
pp. 1335-1341 ◽  
Author(s):  
R.E.A. Forder ◽  
G.S. Nattrass ◽  
M.S. Geier ◽  
R.J. Hughes ◽  
P.I. Hynd
Keyword(s):  
Broiler Chickens ◽  
Necrotic Enteritis ◽  
Mucin Synthesis ◽  
Quantitative Analyses

scholarly journals Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2027
Author(s):  
Doaa Ibrahim ◽  
Tamer Ahmed Ismail ◽  
Eman Khalifa ◽  
Shaimaa A. Abd El-Kader ◽  
Dalia Ibrahim Mohamed ◽  
...  
Keyword(s):  
Growth Performance ◽  
Clostridium Perfringens ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Economic Benefits ◽  
Production Costs ◽  
Broiler Chicks ◽  
Necrotic Enteritis ◽  
Feed Conversion ◽  
Intestinal Lesion

Necrotic enteritis (NE) caused by Clostridium perfringens (C. perfringens) results in impaired bird growth performance and increased production costs. Nanotechnology application in the poultry industry to control NE outbreaks is still not completely clarified. Therefore, the efficacy of dietary garlic nano-hydrogel (G-NHG) on broilers growth performance, intestinal integrity, economic returns and its potency to alleviate C. perfringens levels using NE challenge model were addressed. A total of 1200 male broiler chicks (Ross 308) were assigned into six groups; four supplemented with 100, 200, 300 or 400 mg of G-NHG/kg diet and co-challenged with C. perfringens at 21, 22 and 23 d of age and two control groups fed basal diet with or without C. perfringens challenge. Over the total growing period, the 400 mg/kg G-NHG group had the most improved body weight gain and feed conversion efficiency regardless of challenge. Parallel with these results, the mRNA expression of genes encoding digestive enzymes (alpha 2A amylase (AMY2A), pancreatic lipase (PNLIP) and cholecystokinin (CCK)) and intestinal barriers (junctional adhesion molecule-2 (JAM-2), occludin and mucin-2 (Muc-2)) were increased in groups fed G-NHG at higher levels to be nearly similar to those in the unchallenged group. At 14 d post challenge, real-time PCR results revealed that inclusion of G-NHG led to a dose-dependently decrease in the C. perfringens population, thereby decreasing the birds’ intestinal lesion score and mortality rates. Using 400 mg/kg of G-NHG remarkably ameliorated the adverse effects of NE caused by C. perfringens challenge, which contributed to better growth performance of challenged birds with rational economic benefits.

scholarly journals Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Danish Sharafat Rajput ◽  
Dong Zeng ◽  
Abdul Khalique ◽  
Samia Sharafat Rajput ◽  
Hesong Wang ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Production Systems ◽  
Economic Losses ◽  
Necrotic Enteritis ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
Broiler Performance ◽  
Antibiotic Growth Promoters ◽  
Microbial Strains

AbstractNecrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfringens, a pathogenic bacterium, and normal resident of the intestinal microflora of healthy broiler chickens. Gastrointestinal tract (GIT) of broiler chicken is considered as the most integral part of pathogen’s entrance, their production and disease prevention. Interaction between C. perfringens and other pathogens such as Escherichia coli and Salmonella present in the small intestine may contribute to the development of NE in broiler chickens. The antibiotic therapy was used to treat the NE; however European Union has imposed a strict ban due to the negative implications of drug resistance. Moreover, antibiotic growth promoters cause adverse effects on human health as results of withdrawal of antibiotic residues in the chicken meat. After restriction on use of antibiotics, numerous studies have been carried out to investigate the alternatives to antibiotics for controlling NE. Thus, possible alternatives to prevent NE are bio-therapeutic agents (Probiotics), prebiotics, organic acids and essential oils which help in nutrients digestion, immunity enhancement and overall broiler performance. Recently, probiotics are extensively used alternatives to antibiotics for improving host health status and making them efficient in production. The aim of review is to describe a replacement to antibiotics by using different microbial strains as probiotics such as bacteria and yeasts etc. having bacteriostatic properties which inhibit growth of pathogens and neutralize the toxins by different modes of action.

scholarly journals Effects of cLFchimera peptide on intestinal morphology, integrity, microbiota, and immune cells in broiler chickens challenged with necrotic enteritis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ali Daneshmand ◽  
Hassan Kermanshahi ◽  
Mohammad Hadi Sekhavati ◽  
Ali Javadmanesh ◽  
Monireh Ahmadian ◽  
...  
Keyword(s):  
Immune Cells ◽  
Synthetic Peptide ◽  
Broiler Chickens ◽  
Intestinal Morphology ◽  
Broiler Chicks ◽  
Growth Promoter ◽  
Necrotic Enteritis ◽  
Gut Health ◽  
Junctional Proteins ◽  
Intestinal Lesions

Abstract Three hundred and sixty 1-day-old male broiler chicks were randomly allocated to 4 treatments of 6 replicates to evaluate the effects of cLFchimera, a recombinant antimicrobial peptide (AMP), on gut health attributes of broiler chickens under necrotic enteritis (NE) challenge. Treatments were as follows: (T1) unchallenged group fed with corn-soybean meal (CSM) without NE challenge and additives (NC); (T2) group fed with CSM and challenged with NE without any additives (PC); (T3) PC group supplemented with 20 mg cLFchimera/kg diet (AMP); (T4) PC group supplemented with 45 mg antibiotic (bacitracin methylene disalicylate)/kg diet (antibiotic). Birds were sampled for villi morphology, ileal microbiota, and jejunal gene expression of cytokines, tight junctions proteins, and mucin. Results showed that AMP ameliorated NE-related intestinal lesions, reduced mortality, and rehabilitated jejunal villi morphology in NE challenged birds. While the antibiotic non-selectively reduced the count of bacteria, AMP restored microflora balance in the ileum of challenged birds. cLFchimera regulated the expression of cytokines, junctional proteins, and mucin transcripts in the jejunum of NE challenged birds. In conclusion, cLFchimera can be a reliable candidate to substitute growth promoter antibiotics, while more research is required to unveil the exact mode of action of this synthetic peptide.

The Effects of Berberine on Clostridium Perfringens Induced Necrotic Enteritis in Broiler Chickens

2017 ◽  
Vol 08 (03) ◽  
Author(s):  
David Xiang Y ◽  
Zhiyong H ◽  
Wenyue W ◽  
Colin P ◽  
Zhi cheng X
Keyword(s):  
Clostridium Perfringens ◽  
Broiler Chickens ◽  
Necrotic Enteritis

scholarly journals Draft Genome Sequence of Clostridium perfringens Strain TAMU, Which Causes Necrotic Enteritis in Broiler Chickens

2020 ◽  
Vol 9 (4) ◽  
Author(s):  
Catherine Ausland ◽  
Adil Sabr Al-Ogaili ◽  
Juan D. Latorre ◽  
Guillermo Tellez-Isaias ◽  
Billy M. Hargis ◽  
...  
Keyword(s):  
Clostridium Perfringens ◽  
Genome Sequence ◽  
Broiler Chickens ◽  
Draft Genome ◽  
Gastrointestinal Diseases ◽  
Intervention Strategies ◽  
Draft Genome Sequence ◽  
Necrotic Enteritis ◽  
Content Type ◽  
Deadly Disease

Clostridium perfringens causes severe gastrointestinal diseases, which include necrotic enteritis (NE) in chickens, a deadly disease worldwide. We report here the draft genome sequence of Clostridium perfringens strain TAMU, which was used in developing an NE chicken challenge model. This C. perfringens TAMU genome sequence will aid in advancing potential intervention strategies to reduce NE pathogenesis.

Live attenuated vaccine-based control of necrotic enteritis of broiler chickens

2006 ◽  
Vol 113 (1-2) ◽  
pp. 25-34 ◽  
Author(s):  
D.R. Thompson ◽  
V.R. Parreira ◽  
R.R. Kulkarni ◽  
J.F. Prescott
Keyword(s):  
Broiler Chickens ◽  
Necrotic Enteritis ◽  
Live Attenuated Vaccine ◽  
Attenuated Vaccine

scholarly journals Feeding of yeast cell wall extracts during a necrotic enteritis challenge enhances cell growth, survival and immune signaling in the jejunum of broiler chickens

2020 ◽  
Vol 99 (6) ◽  
pp. 2955-2966
Author(s):  
Casey N. Johnson ◽  
Mohammed M. Hashim ◽  
Christopher A. Bailey ◽  
James A. Byrd ◽  
Michael H. Kogut ◽  
...  
Keyword(s):  
Cell Wall ◽  
Cell Growth ◽  
Yeast Cell ◽  
Broiler Chickens ◽  
Yeast Cell Wall ◽  
Necrotic Enteritis ◽  
Immune Signaling
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