scholarly journals Effect of killed whole yeast cell prebiotic supplementation on broiler performance and intestinal immune cell parameters

2012 ◽  
Vol 91 (1) ◽  
pp. 107-111 ◽  
Author(s):  
R. Shanmugasundaram ◽  
R.K. Selvaraj
Keyword(s):  
Yeast Cell ◽  
Immune Cell ◽  
Broiler Performance ◽  
Cell Parameters

scholarly journals Effect of yeast cell product (CitriStim) supplementation on turkey performance and intestinal immune cell parameters during an experimental lipopolysaccharide injection

2014 ◽  
Vol 93 (11) ◽  
pp. 2763-2771 ◽  
Author(s):  
Revathi Shanmugasundaram ◽  
Mamduh Sifri ◽  
Ramesh Jeyabalan ◽  
Ramesh K. Selvaraj
Keyword(s):  
Yeast Cell ◽  
Immune Cell ◽  
Cell Parameters ◽  
Cell Product

Immune cell parameters in severely depressed patients: negative findings

1989 ◽  
Vol 17 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Michael Maes ◽  
Eugène Bosmans ◽  
Eduard Suy ◽  
Bob Minner ◽  
Jef Raus
Keyword(s):  
Immune Cell ◽  
Cell Parameters ◽  
Depressed Patients ◽  
Negative Findings

scholarly journals T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Julia Sbierski-Kind ◽  
David Goldeck ◽  
Nikolaus Buchmann ◽  
Joachim Spranger ◽  
Hans-Dieter Volk ◽  
...  
Keyword(s):  
T Cells ◽  
Insulin Sensitivity ◽  
Mononuclear Cells ◽  
Immune Cell ◽  
Linear Regression Analysis ◽  
Multiparameter Flow Cytometry ◽  
Low Grade ◽  
Activated T Cells ◽  
Cell Parameters ◽  
Aging Study

Abstract Background Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers and metabolically healthy obesity (MHO) are scarce. Methods In this cross-sectional analysis, we included a sample of 437 older participants (60–84 years) from the Berlin Aging Study II (BASE-II). Peripheral blood mononuclear cells were isolated, immune cell subsets were analyzed with multiparameter flow cytometry and systemic cytokine levels were measured. Immune cell parameters were correlated with metabolic measures and multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Results We found that frequencies of naïve and memory CD4+ and CD8+ T cells inversely correlated with measures for insulin sensitivity in the older population. Moreover, the percentages of naïve CD4+ and CD8+ T cells were significantly higher, whereas activated T cells and IL-6 levels were lower in IS compared to insulin resistant (IR) obese individuals. The percentages of naïve CD4+ and CD8+ T cells were predictive for impaired insulin sensitivity (ß = 0.16, p = 0.01 and ß = 0.11, p = 0.04), and the association of naïve CD4+ T cells with insulin sensitivity persisted after multivariate adjustment (ß = 0.14, p = 0.02). Conclusions These findings support the hypothesis that parameters of systemic inflammation can differentiate IS from IR obese individuals that are at higher risk for cardiometabolic diseases and may have clinical implications with regard to obesity treatment stratification. Trial registration DRKS00009277. Registered 31 August 2015 - Retrospectively registered.

Alteration of immune cell parameters during the development of experimental autoimmune orchitis in rats

Andrologia ◽  
2003 ◽  
Vol 35 (1) ◽  
pp. 6-7
Author(s):  
S. Graenz ◽  
A. Lewen ◽  
M. P. Hedger ◽  
J. Seitz ◽  
G. Aumüller ◽  
...  
Keyword(s):  
Immune Cell ◽  
Cell Parameters ◽  
Autoimmune Orchitis ◽  
Experimental Autoimmune

scholarly journals Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Irene Martínez de Toda ◽  
Carmen Vida ◽  
Luis Sanz San Miguel ◽  
Mónica De la Fuente
Keyword(s):  
Immune Cells ◽  
Immune Cell ◽  
Nk Activity ◽  
Aging Research ◽  
Very Old ◽  
Inflammatory Stress ◽  
Adult Age ◽  
Cell Parameters ◽  
Inflammatory Parameters ◽  
New Perspective

According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and if there would be any changes in this prediction, depending on the age of the subject. Therefore, a longitudinal study in mice was performed analysing immune function (chemotaxis of macrophages and lymphocytes, phagocytosis of macrophages, natural killer (NK) activity, and lymphoproliferation capacity), antioxidant (catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities as well as reduced glutathione (GSH) concentrations), oxidant (oxidized glutathione (GSSG), superoxide anion, and malondialdehyde (MDA) concentrations), and inflammation-related markers (basal release of IL-1β, IL-6, TNF-α, and IL-10) in peritoneal leukocytes from mice at the adult, mature, old, very old, and long-lived ages (40, 56, 72, 96, and 120±4 weeks of age, respectively). The results reveal that some of the investigated parameters are determinants of longevity at the adult age (lymphoproliferative capacity, lymphocyte chemotaxis, macrophage chemotaxis and phagocytosis, GPx activity, and GSH, MDA, IL-6, TNF-α, and IL-10 concentrations), and therefore, they could be proposed as markers of the rate of aging. However, other parameters are predictive of extreme longevity only at the very old age (NK activity, CAT and GR activities, and IL-6 and IL-1β concentrations), and as such, they could reflect some of the adaptive mechanisms underlying the achievement of high longevity. Nevertheless, although preliminary, the results of the present study provide a new perspective on the use of function, redox, and inflammatory parameters in immune cells as prognostic tools in aging research and represent a novel benchmark for future work aimed at prediction of lifespan.

scholarly journals T cell phenotypes associated with insulin resistance: Results from the Berlin Aging Study II

2020 ◽  
Author(s):  
Julia Sbierski-Kind ◽  
David Goldeck ◽  
Nikolaus Buchmann ◽  
Joachim Spranger ◽  
Hans-Dieter Volk ◽  
...  
Keyword(s):  
T Cells ◽  
Insulin Sensitivity ◽  
Mononuclear Cells ◽  
Immune Cell ◽  
Linear Regression Analysis ◽  
Multiparameter Flow Cytometry ◽  
Low Grade ◽  
Cell Parameters ◽  
Aging Study ◽  
Metabolically Healthy

Abstract Background Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS) and metabolically healthy. The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers and metabolically healthy obesity (MHO) are scarce. Methods In this cross-sectional analysis, we included a sample of 437 older participants (60-84 years) from the Berlin Aging Study II (BASE-II). Peripheral blood mononuclear cells were isolated, immune cell subsets were analyzed with multiparameter flow cytometry and systemic cytokine levels were measured. Immune cell parameters were correlated with metabolic measures and multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Results We found that frequencies of naïve and memory CD4+ and CD8+ T cells inversely correlated with measures for insulin sensitivity in the older population. Moreover, the percentages of naïve CD4+ and CD8+ T cells were significantly higher, whereas activated T cells and IL-6 levels were lower in IS compared to insulin resistant (IR) obese individuals. The percentages of naïve CD4+ and CD8+ T cells were predictive for impaired insulin sensitivity (ß=0.16, p=0.01 and ß=0.11, p=0.04), and the association of naïve CD4+ T cells with insulin sensitivity persisted after multivariate adjustment (ß=0.14, p=0.02). Conclusions These findings support the hypothesis that parameters of systemic inflammation can differentiate IS from IR obese individuals that are at higher risk for cardiometabolic diseases and may have clinical implications with regard to obesity treatment stratification. Trial registration: DRKS00009277. Registered 31 August 2015 - Retrospectively registered, https://www.base2.mpg.de/de

scholarly journals Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome

2021 ◽  
Vol 11 (9) ◽  
pp. 841
Author(s):  
Mihaela Surcel ◽  
Adriana Munteanu ◽  
Gheorghita Isvoranu ◽  
Alef Ibram ◽  
Constantin Caruntu ◽  
...  
Keyword(s):  
Immune Cells ◽  
Immune Cell ◽  
Preventive Therapy ◽  
Intestinal Microbiome ◽  
Mice Model ◽  
Cell Parameters ◽  
Immune Parameters ◽  
Therapy Strategy ◽  
Cellular Immune ◽  
Psoriatic Lesions

Psoriasis has a multifactorial pathogenesis and recently it was shown that alterations in the skin and intestinal microbiome are involved in the pathogenesis of psoriasis. Therefore, microbiome restoration becomes a promising preventive/therapy strategy in psoriasis. In our pre-clinical study design using a mice model of induced psoriatic dermatitis (Ps) we have tested the proof-of-concept that IgY raised against pathological human bacteria resistant to antibiotics can alleviate psoriatic lesions and restore deregulated immune cell parameters. Besides clinical evaluation of the mice and histology of the developed psoriatic lesions, cellular immune parameters were monitored. Immune cells populations/subpopulations from peripheral blood and spleen cell suspensions that follow the clinical improvement were assessed using flow cytometry. We have quantified T lymphocytes (CD3ε+) with T-helper (CD4+CD8−) and T-suppressor/cytotoxic (CD8a+CD4−) subsets, B lymphocytes (CD3ε−CD19+) and NK cells (CD3ε−NK1.1+). Improved clinical evolution of the induced Ps along with the restoration of immune cells parameters were obtained when orally IgY was administered. We pin-point that IgY specific compound can be used as a possible pre-biotic-like alternative adjuvant in psoriasis.

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