scholarly journals The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration

2011 ◽  
Vol 90 (11) ◽  
pp. 2548-2556 ◽  
Author(s):  
P.L. Zeng ◽  
X.G. Li ◽  
X.Q. Wang ◽  
D.X. Zhang ◽  
G. Shu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Small Intestine ◽  
Amino Acid ◽  
Acid Concentration ◽  
Amino Acid Concentration ◽  
Neutral Amino Acid ◽  
Amino Acid Transporters ◽  
Chick Embryos ◽  
The Relationship

ACE2 and gut amino acid transport

2020 ◽  
Vol 134 (21) ◽  
pp. 2823-2833 ◽  
Author(s):  
Simone M.R. Camargo ◽  
Raphael N. Vuille-dit-Bille ◽  
Chantal F. Meier ◽  
François Verrey
Keyword(s):  
Amino Acids ◽  
Small Intestine ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Neutral Amino Acid ◽  
Amino Acid Transporters ◽  
Type I ◽  
Small Intestinal Mucosa ◽  
Neutral Amino Acid Transporter ◽  
Acid Transporter

Abstract ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a broad tissue distribution with highest expression levels at the brush border membrane (BBM) of small intestine enterocytes and a lower expression in stomach and colon. In small intestinal mucosa, ACE2 mRNA expression appears to increase with age and to display higher levels in patients taking ACE-inhibitors (ACE-I). There, ACE2 protein heterodimerizes with the neutral amino acid transporter Broad neutral Amino acid Transporter 1 (B0AT1) (SLC6A19) or the imino acid transporter Sodium-dependent Imino Transporter 1 (SIT1) (SLC6A20), associations that are required for the surface expression of these transport proteins. These heterodimers can form quaternary structures able to function as binding sites for SARS-CoV-2 spike glycoproteins. The heterodimerization of the carboxypeptidase ACE2 with B0AT1 is suggested to favor the direct supply of substrate amino acids to the transporter, but whether this association impacts the ability of ACE2 to mediate viral infection is not known. B0AT1 mutations cause Hartnup disorder, a condition characterized by neutral aminoaciduria and, in some cases, pellagra-like symptoms, such as photosensitive rash, diarrhea, and cerebellar ataxia. Correspondingly, the lack of ACE2 and the concurrent absence of B0AT1 expression in small intestine causes a decrease in l-tryptophan absorption, niacin deficiency, decreased intestinal antimicrobial peptide production, and increased susceptibility to inflammatory bowel disease (IBD) in mice. Thus, the abundant expression of ACE2 in small intestine and its association with amino acid transporters appears to play a crucial role for the digestion of peptides and the absorption of amino acids and, thereby, for the maintenance of structural and functional gut integrity.

Effects of dietary protein and amino acid levels on the expression of selected cationic amino acid transporters and serum amino acid concentration in growing pigs

2012 ◽  
Vol 66 (4) ◽  
pp. 257-270 ◽  
Author(s):  
Héctor García-Villalobos ◽  
Adriana Morales-Trejo ◽  
Benedicto A. Araiza-Piña ◽  
John K. Htoo ◽  
Miguel Cervantes-Ramírez
Keyword(s):  
Amino Acid ◽  
Acid Concentration ◽  
Dietary Protein ◽  
Growing Pigs ◽  
Amino Acid Concentration ◽  
Amino Acid Transporters ◽  
Cationic Amino Acid ◽  
Amino Acid Levels

scholarly journals Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression

2011 ◽  
Vol 10 (3) ◽  
pp. 328-340 ◽  
Author(s):  
Edward H. Byrne ◽  
Ian Prosser ◽  
Nira Muttucumaru ◽  
Tanya Y. Curtis ◽  
Astrid Wingler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Protein Kinase ◽  
Free Amino Acid ◽  
Acid Concentration ◽  
Free Amino ◽  
Amino Acid Concentration ◽  
Type Protein

scholarly journals Dietary methionine level alters growth, digestibility, and gene expression of amino acid transporters in meat-type chickens

2020 ◽  
Vol 99 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Naiara S. Fagundes ◽  
Marie C. Milfort ◽  
Susan M. Williams ◽  
Manuel J. Da Costa ◽  
Alberta L. Fuller ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Amino Acid Transporters ◽  
Methionine Level ◽  
Meat Type

scholarly journals AMINO ACID CONCENTRATION BY A FREE CELL NEOPLASM. STRUCTURAL INFLUENCES

1954 ◽  
Vol 209 (1) ◽  
pp. 395-411 ◽  
Author(s):  
Thomas R. Riggs ◽  
Barbara A. Coyne ◽  
Halvor N. Christensen
Keyword(s):  
Amino Acid ◽  
Acid Concentration ◽  
Free Cell ◽  
Amino Acid Concentration ◽  
Cell Neoplasm
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