scholarly journals Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens

2009 ◽  
Vol 88 (3) ◽  
pp. 504-510 ◽  
Author(s):  
G.H. Wang ◽  
C.Y. Xue ◽  
F. Chen ◽  
Y.L. Ma ◽  
X.B. Zhang ◽  
...  
Keyword(s):  
Immune Function ◽  
Ochratoxin A ◽  
Broiler Chickens

scholarly journals Effects of age on immune function in broiler chickens

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Bochen Song ◽  
Dazhi Tang ◽  
Shaojia Yan ◽  
Hao Fan ◽  
Guang Li ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Function ◽  
Cellular Immunity ◽  
Mucosal Immunity ◽  
Peripheral Blood ◽  
Broiler Chickens ◽  
Mrna Levels ◽  
Cell Ratio ◽  
Cell Functions ◽  
Ifn Γ

Abstract Background There are many diseases in poultry, many of which are caused by poor immune function. It is not clear how cytokines and various immune cell functions change with age in modern broilers. The purpose of this study was to explore the patterns of development of the immunity of the broiler chickens in cage. Results The results showed that there were 3 development patterns of immunity in the broiler chickens. The first pattern was Down-Up. Cytokines and some immune indicators first decreased and then increased, and the lowest levels of immunity basically occurred from d 6 to 13. The second pattern was Up-Down, and from d 30 to 34, the highest levels of non-specific cellular immunity components, such as the peripheral blood mononuclear macrophage ratio, specific cellular immunity components, such as the peripheral blood helper T (Th) cell ratio and T cell and B cell proliferation activity, and mucosal immunity components, such as the ileal CD4, TGF-β1 and IgA mRNA levels, were observed. The third pattern was Up-Up, and the levels of the non-specific cellular immunity components, such as the serum nitric oxide (NO), C3 and C4 levels, the specific cellular immunity components, such as the spleen index, peripheral blood IL-2, IFN-γ/IL-4, cytotoxic T (Tc) cell ratio, and splenic NF-κB mRNA levels, the humoral immunity components, such as the serum IgG level, the mucosal immunity components, such as the ileal MHC-II, CD3d, TCRβ subunit, TCRζ subunit, IFN-γ, pIgR mRNA and ileal mucosa sIgA levels, were continuing to increase from d 1 to 34. Conclusions It could be concluded that the immune system and its function have not developed well in the broiler chickens d 6 to 13 and that the immune system does not mature until d 30 to 34 in the broiler chickens in cages. It is necessary to enhance the immune function of the broiler chickens through nutritional measures from d 1 to 30.

In vitro effect of ochratoxin A and deoxynivalenol on the expression of interleukin 5 and interferon-gamma in broiler chicken lymphocytes

2016 ◽  
Vol 9 (2) ◽  
pp. 299-304 ◽  
Author(s):  
C. Lautert ◽  
L. Ferreiro ◽  
M.I. Azevedo ◽  
S.A. Botton ◽  
J.T. Santos ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Interferon Gamma ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Fungal Metabolites ◽  
Interleukin 5 ◽  
T Helper 2 ◽  
Ifn Γ ◽  
Vitro Effect

Cytokines are proteins secreted by cells of innate and acquired immunity, produced in response to various antigens and responsible for mediating several function of these cells. Our study evaluated the profile of cytokines interleukin 5 (IL-5) and interferon gamma (IFN-γ), induced in lymphocytes of broiler chickens in response to secondary fungal metabolites ochratoxin A (OTA) and deoxynivalenol (DON) at concentrations of 0.001, 0.01, 0.1 and 1 μg/ml. The quantification of the cytokines was analysed at 24, 48 and 72 h after incubation with mycotoxins, using real-time PCR (qRT-PCR). The results obtained showed that OTA induced mRNA synthesis of IL-5 at concentrations 0.001, 0.1 and 1 μg/ml after 24 h of lymphocyte incubation, while at 48 h only the expression of the IL-5 cytokine at a concentration of 1 μg/ml (P<0.05) was detected. DON in a concentration of 1 μg/ml induced the expression of IL-5 in the lymphocytes only at 48 h post-incubation period (P<0.05). Regarding IFN-γ, gene expression was not observed in the lymphocytes of broiler chickens incubated with OTA and DON. The data obtained represent a profile of response mediated by T helper 2 cells to the exposure of broiler chicken immune cells to different concentrations of OTA and DON.

scholarly journals The effect of light intensity on the behavior, eye and leg health, and immune function of broiler chickens

2009 ◽  
Vol 88 (1) ◽  
pp. 20-28 ◽  
Author(s):  
R.A. Blatchford ◽  
K.C. Klasing ◽  
H.L. Shivaprasad ◽  
P.S. Wakenell ◽  
G.S. Archer ◽  
...  
Keyword(s):  
Light Intensity ◽  
Immune Function ◽  
Broiler Chickens ◽  
Effect Of Light

Effects of Compound Probiotics on Growth Performance, Intestinal Microflora and Immune Function of Broilers

2014 ◽  
Vol 997 ◽  
pp. 178-184
Author(s):  
Hong Ling Wang ◽  
Yu Hong Yang ◽  
Jia Qing Wang ◽  
Zhuo Wang ◽  
Shuang Ma
Keyword(s):  
Immune Function ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Intestinal Microflora ◽  
Basal Diet ◽  
Experimental Period ◽  
Control Group ◽  
Group Iii ◽  
Serum Biochemical ◽  
Anti Body

This study aimed to investigate the efficacy of compound probiotics on broiler performance, intestinal microflora, immune function and serum biochemical indicators. Four hundred one-d-old female broiler chickens were randomly divided into 4 groups with 4 replicates in each group and 25 chickens per replication. The chickens in groupI(control group) were fed a basal diet, experimental groups II, III and IVwere fed the basal diet supplemented with 0.1%, 0.2% and 0.4% compound probiotics. The results of this work were as follows: (1) during the experimental period, compared with control group, the average daily in group III was significantly increased (P<0.05), the feed/gain and average daily feed intake were significantly lower (P<0.05); (2) at the age of 14 and 28 days, the number of cecal Lactic acid in group II and III were significantly higher than the control (P<0.05) and the content of E.coli has the opposite results. (3) the anti-body titer in group III was the highest, and significantly higher compared to the control (P<0.05), but there were no significantly differences between group IV and control group (P>0.05). (4) serum biochemical indexes of broilers in group III and IVwere significantly increased than that in control group (P<0.05). In conclusion, the supplementation of 0.2% compound probiotics could promote the growth performance, improve the cecal mico-ecosystem, enhance the anti-body titer and biochemical indexes in serum.

scholarly journals Effects of antibacterial peptide combinations on growth performance, intestinal health, and immune function of broiler chickens

2020 ◽  
Vol 99 (12) ◽  
pp. 6481-6492
Author(s):  
Zi Xie ◽  
Qiqi Zhao ◽  
Huan Wang ◽  
Lijun Wen ◽  
Wei Li ◽  
...  
Keyword(s):  
Immune Function ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Antibacterial Peptide ◽  
Intestinal Health

scholarly journals Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4435 ◽  
Author(s):  
Lin Yuan ◽  
Wanli Li ◽  
Qianqian Huo ◽  
Chenhong Du ◽  
Zhixiang Wang ◽  
...  
Keyword(s):  
Immune Function ◽  
Growth Performance ◽  
Mrna Expression ◽  
Broiler Chickens ◽  
Average Daily Gain ◽  
Interleukin 2 ◽  
Test Group ◽  
Basal Diet ◽  
Toll Like Receptor 5 ◽  
Daily Gain

This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFNγ) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21-day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day-old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation downregulated mRNA expression of IFNγ, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA.

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