scholarly journals Production Traits and Alloantigen Systems in Lines of Chickens Selected for High or Low Antibody Responses to Sheep Erythrocytes

1990 ◽  
Vol 69 (6) ◽  
pp. 871-878 ◽  
Author(s):  
A. MARTIN ◽  
E.A. DUNNINGTON ◽  
W.B. GROSS ◽  
W.E. BRILES ◽  
R.W. BRILES ◽  
...  
Keyword(s):  
Antibody Responses ◽  
Production Traits ◽  
Sheep Erythrocytes

scholarly journals ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 ◽  
Vol 140 (1) ◽  
pp. 126-145 ◽  
Author(s):  
M. B. Pepys
Keyword(s):  
B Cells ◽  
Antibody Response ◽  
B Cell ◽  
Antibody Production ◽  
Antibody Responses ◽  
Cobra Venom ◽  
Sheep Erythrocytes ◽  
C3 Receptors

In an in vivo study in mice, suppression by the C3-cleaving protein of cobra venom (CoF), and other C3-reactive agents (zymosan, aggregated IgG, anti-C3 antibodies, and type III pneumococcal polysaccharide) of the thymus-dependent antibody responses to sheep erythrocytes, ovalbumin, and human IgG was demonstrated. The thymus-independent antibody response to polyvinyl-pyrrolidone was however unaffected by CoF. These and other published observations suggest that there may be a requirement for functional C3 in induction of thymus-dependent but not thymus-independent antibody production. A model for the role of C3 in lymphocyte cooperation is proposed based on these data analyzed in the light of existing knowledge of this process. It is postulated that fixed C3 interacting with macrophage See PDF for Structure and B-cell C3 receptors might enhance or facilitate T-dependent presentation of antigen to B cells.

scholarly journals IMMUNE RESPONSES IN VITRO

1974 ◽  
Vol 140 (4) ◽  
pp. 921-938 ◽  
Author(s):  
Carl W. Pierce ◽  
Judith A. Kapp ◽  
Susan M. Solliday ◽  
Martin E. Dorf ◽  
Baruj Benacerraf
Keyword(s):  
Immune Responses ◽  
Lymphoid Cells ◽  
Antibody Responses ◽  
Current Understanding ◽  
Spleen Cells ◽  
Sheep Erythrocytes ◽  
Selective Suppression ◽  
D Region ◽  
Stimulate Antibody

The effects of alloantisera against leukocyte alloantigens on plaque-forming cell (PFC) responses to sheep erythrocytes and the terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by mouse spleen cells in vitro have been investigated. Polyspecific antibodies against both H-2 and non-H-2 alloantigens on responding spleen cells suppressed both IgM and IgG PFC responses; antisera against alloantigens coded for by the K and I regions, but not the D region, of the H-2 complex also effectively suppressed PFC responses. The suppression was not due to cytotoxicity to the spleen cells or anti-immunoglobulin activity in the sera and was directly related to the amount of antiserum added to the cultures. The suppression was specific for spleen cells against which the alloantiserum was directed. The alloantisera suppressed responses most effectively when present during the first 24 h of incubation, and although not rendering lymphoid cells incapable of developing PFC responses after removal of noncell-bound antibody, did act by interfering with successful initiation of the PFC response. The alloantisera suppressed both IgM and IgG PFC responses when directed against alloantigens only on macrophages, but selectively suppressed IgG responses when directed against alloantigens only on lymphoid cells. The alloantisera did not interfere with the ability of macrophages to bind GAT or to support the viability of the lymphoid cells, but did interfere with the ability of macrophage-associated antigen to effectively stimulate antibody responses by the lymphoid cells. Possible mechanisms for the effects of alloantisera on macrophages and the selective suppression of IgG responses when the antisera are directed against alloantigens on lymphoid cells are discussed with reference to our current understanding of genetic restrictions governing cell interactions in the development of antibody responses in mice.

scholarly journals Complement Receptors 1 and 2 in Murine Antibody Responses to IgM-Complexed and Uncomplexed Sheep Erythrocytes

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41968 ◽  
Author(s):  
Christian Rutemark ◽  
Anna Bergman ◽  
Andrew Getahun ◽  
Jenny Hallgren ◽  
Frida Henningsson ◽  
...  
Keyword(s):  
Antibody Responses ◽  
Complement Receptors ◽  
Sheep Erythrocytes ◽  
Murine Antibody
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