scholarly journals Influence of Diet Composition on Hepatic Lipid Deposition in Two Lines of Australorps Selected for Liver Fat Differences

1987 ◽  
Vol 66 (4) ◽  
pp. 700-704
Author(s):  
L.S. JENSEN
Keyword(s):  
Diet Composition ◽  
Liver Fat ◽  
Lipid Deposition ◽  
Hepatic Lipid

Comment on “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”

Science ◽  
2021 ◽  
Vol 373 (6554) ◽  
pp. eabj1696
Author(s):  
Charles Brenner
Keyword(s):  
Placebo Group ◽  
Insulin Sensitivity ◽  
Randomized Trial ◽  
Lipid Content ◽  
Liver Fat ◽  
Hepatic Lipid ◽  
Nicotinamide Mononucleotide ◽  
Hepatic Lipid Content

Yoshino et al. (Reports, 11 June 2021, p. 1224) have reported that nicotinamide mononucleotide (NMN) increases muscle insulin sensitivity in prediabetic women. However, the 13 women who received NMN had hepatic lipid content of 6.3 ± 1.2%, whereas the 12 in the placebo group had 14.8 ± 2.0% (P = 0.003). Given that a target of NMN is liver fat clearance, this was not an effectively randomized trial.

The Hepatoprotective Effects of Zinc Glycine on Liver Injury in Meat Duck Through Alleviating Hepatic Lipid Deposition and Inflammation

2019 ◽  
Vol 195 (2) ◽  
pp. 569-578 ◽  
Author(s):  
Yunhan Zhang ◽  
Yaqi Chang ◽  
Ting Yang ◽  
Min Wen ◽  
Zhengyu Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lipid Deposition ◽  
Hepatic Lipid ◽  
Hepatoprotective Effects ◽  
Meat Duck

scholarly journals Cyclocarya paliurus extract attenuates hepatic lipid deposition in HepG2 cells by the lipophagy pathway

2020 ◽  
Vol 58 (1) ◽  
pp. 838-844
Author(s):  
Wanwei Yang ◽  
Cuihua Jiang ◽  
Zhiguo Wang ◽  
Jian Zhang ◽  
Xiaodong Mao ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Lipid Deposition ◽  
Cyclocarya Paliurus ◽  
Hepatic Lipid

Differential effects of acute and chronic zinc (Zn) exposure on hepatic lipid deposition and metabolism in yellow catfish Pelteobagrus fulvidraco

2013 ◽  
Vol 132-133 ◽  
pp. 173-181 ◽  
Author(s):  
Jia-Lang Zheng ◽  
Zhi Luo ◽  
Cai-Xia Liu ◽  
Qi-Liang Chen ◽  
Xiao-Ying Tan ◽  
...  
Keyword(s):  
Pelteobagrus Fulvidraco ◽  
Lipid Deposition ◽  
Yellow Catfish ◽  
Hepatic Lipid ◽  
Differential Effects

scholarly journals The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice

2020 ◽  
Vol 61 (7) ◽  
pp. 1052-1064 ◽  
Author(s):  
Minjuan Ma ◽  
Rui Duan ◽  
Lulu Shen ◽  
Mengting Liu ◽  
Yaya Ji ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Lipid Deposition ◽  
In Vivo Models ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Regulatory Circuit ◽  
Murine Liver

Excessive lipid deposition is a hallmark of NAFLD. Although much has been learned about the enzymes and metabolites involved in NAFLD, few studies have focused on the role of long noncoding RNAs (lncRNAs) in hepatic lipid accumulation. Here, using in vitro and in vivo models of NAFLD, we found that the lncRNA Gm15622 is highly expressed in the liver of obese mice fed a HFD and in murine liver (AML-12) cells treated with free fatty acids. Investigating the molecular mechanism in the liver-enriched expression of Gm15622 and its effects on lipid accumulation in hepatocytes and on NAFLD pathogenesis, we found that Gm15622 acts as a sponge for the microRNA miR-742-3p. This sponging activity increased the expression of the transcriptional regulator SREBP-1c and promoted lipid accumulation in the liver of the HFD mice and AML-12 cells. Moreover, further results indicated that metformin suppresses Gm15622 and alleviates NAFLD-associated lipid deposition in mice. In conclusion, we have identified an lncRNA Gm15622/miR-742-3p/SREBP-1c regulatory circuit associated with NAFLD in mice, a finding that significantly advances our insight into how lipid metabolism and accumulation are altered in this metabolic disorder. Our results also suggest that Gm15622 may be a potential therapeutic target for managing NAFLD.

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